Juventus will aim to overturn a 2-0 deficit from the first leg when they welcome Atletico Madrid to Turin in the Uefa Champions League last-16 on Tuesday.
The Italian champions face a tough task against a side famed for their defensive resilience, but they are able to call on the competition's most prolific ever player in their bid to reach the quarter-finals.
Cristiano Ronaldo, scorer of 121 Champions League goals - of which 57 have been decisive, was signed by Juventus from Real Madrid last summer with the chief aim of ending the club's 23-year European Cup drought.
The Portuguese forward sounds determined to cause more heartbreak to an Atletico side he has helped to defeat twice in recent finals with his former club Real.
"We didn't expect to lose the first leg 2-0, but anything can happen, and we want to give a great response in our home, in front of our fans," Ronaldo told Juventus TV.
"These are the great nights, the fantastic ones: the Champions League nights. The team is confident of playing a great game and I am too. To the fans I say: think positive, let's believe. Get ready to come back!"
Ronaldo has certainly contributed to many special Champions League nights, but can he keep alive his hopes of a sixth title?
Here we pick out eight key moments where Ronaldo has made a big difference.
Ronaldo v Porto, April 2009
After drawing the first leg 2-2 at Old Trafford, Manchester United needed to win in Portugal to progress to the semi-finals.
Up stepped a 24-year-old Ronaldo in the sixth minute as the Portuguese forward scored one of the most memorable goals of his career, rifling a shot into the top corner from 40 yards to keep United's title defence alive.
The goal set up a semi-final showdown with domestic rivals Arsenal ...
Ronaldo v Arsenal, May 2009
With the semi-final tie finely poised after United had won the first leg 1-0 at Old Trafford, Arsenal were blown away at the Emirates Stadium as Ronaldo scored twice in a 3-1 win after Park Ji-Sung scored the opener after just eight minutes.
Ronaldo doubled United's lead with a dipping 40-yard free-kick to all but seal his side's place in the final. But it was his second goal, scored after a sweeping counter-attack on 61 minutes, that symbolised United's dominance over their rivals.
Arsenal did pull one back from a Robin van Persie penalty, but it was nothing more than a mere consolation. Ronaldo had delivered the damage and led his side into a second successive final.
Ronaldo v Galatasaray, April 2013
Real Madrid looked set to canter into the Champions League semi-finals after an emphatic 3-0 win over the Turkish side at the Bernabeu.
Ronaldo hammered home Madrid's advantage early in the second leg in Istanbul when he scored the opener after just seven minutes.
However, Galatasaray - cheered on by their typically vociferous support - staged a second-half onslaught, scoring three goals to set up a nervy finish.
It was left to Ronaldo to steer his side home, drilling a shot past goalkeeper Fernando Muslera in injury time.
Ronaldo v Schalke, March 2015
Even in defeat, Ronaldo is victorious. Comfortably leading the last-16 tie after a 2-0 first leg win in Gelsenkirchen, Real Madrid returned to Spain to finish off the job.
But Real Madrid twice fell behind, firstly to Christian Fuchs then former Madrid striker Klaas-Jan Huntelaar. It was left to Ronaldo to level both times to keep the Spanish giants comfortably ahead in the tie, and when Karim Benzema made it 3-2 on the night, Madrid looked to be cruising into the quarter-finals.
However, late goals from Huntelaar and Leroy Sane set up a tense finish inside the Bernabeu as Madrid did just enough to progress. Once again, Ronaldo's goals made all the difference.
Ronaldo v Wolfsburg, April 2016
Wolfsburg arrived in Madrid holding a 2-0 first leg lead in this quarter-final as the German side set out to stun their illustrious opponents.
That lead was wiped out over the course of 86 seconds when Ronaldo scored in the 15th and 17th minutes to level the tie.
The Portuguese forward completed his hat-trick in the 77th minute as Madrid reached the semi-finals. They would go on to claim what would prove the first in a hat-trick of European Cups.
Ronaldo v Atletico Madrid, May 2017
After scoring a hat-trick to guide Madrid comfortably past Bayern Munich in the quarter-finals, Ronaldo was at it again in the semi-final first leg against city rivals Atletico.
The Portuguese forward scored his first goal after 10 minutes, before doubling his and Real's tally after 73 minutes. Ronaldo completed his treble with four minutes remaining to put his side in total command of the tie.
Atletico would win the return fixture 2-1, but Ronaldo's first-leg impact proved decisive.
Ronaldo v Juventus, June 2017
Defending champions Real Madrid were aiming to become the first team in the Champions League era to win back-to-back European Cups.
There was no denying them their place in the history books as Ronaldo led his side to glory in Cardiff. He opened the scoring in the 20th minute, before Mario Madzukic pulled Juve level seven minutes later.
Casemiro restored Real's lead just past the hour mark, with Ronaldo claiming his second three minutes later. Marco Asensio ensured the rout in the 90th minute as Ronaldo collected his third winners medal for the Spanish club.
Ronaldo v Juventus, April 2018
There is little wonder the Italian giants were so keen to sign Ronaldo last summer, if only to stop him scoring against them.
And arguably none of Ronaldo's other 120 Champions League goals are better than his second in Turin during this quarter-final, first leg clash.
After handing Real a third minute lead by prodding home from close range, Ronaldo doubled his team's advantage with a spectacular overhead kick in the 64th minute.
Juventus were reduced to 10-men when Paulo Dybala was sent off soon after Ronaldo's wondergoal, and Marcelo gave Real a 3-0 lead in the 72nd minute.
In the end, Madrid had to progress the hard way after losing the second leg 3-1, but progress they did, and after seeing off Bayern Munich in the semi-finals and Liverpool in the final, Real Madrid and Ronaldo achieved more history with a third successive title.
