She beat BTS, Itzy, Seventeen, Stray Kids and Twice to take home the gong for her solo single, Lalisa.
"Blinks, you're like the most important ones. Thank you so much for making this happen," she said, referring to Blackpink fans who are colloquially known by the term.
She also thanked bandmates Jennie, Jisoo and Rose in Korean during her speech.
The band picked up the award for Best Metaverse Performance, for their collaboration with video game company PUBG.
Meanwhile, K-pop superstars BTS took home the Group of the Year award, beating Blackpink, City Girls, Foo Fights, Imagine Dragons, Maneskin, Red Hot Chili Peppers and Silk Sonic.
Scroll through the gallery below to see winners at the MTV VMAs 2022
Details on ticket price and venues have not yet been announced.
Blackpink made their debut in August 2016 with the single Square One. Since they arrived on the music scene, the band have had the honour of being the highest-charting female Korean act on the Billboard Hot 100, peaking at No 13 with 2020 single, Ice Cream.
During the group’s brief hiatus, both Rose and Lisa have embarked on solo careers, releasing their respective debut albums in March and September 2021. Jisoo, meanwhile, pursued acting, taking a leading role in the historical romance K-drama, Snowdrop.
Scroll through the gallery below to see photos of Blackpink over the years