The Dh20 million Mahzooz draw jackpot was claimed on Saturday night, the company has confirmed.
The winner's identity was not revealed but is expected to be announced at a press conference next week.
The lucky winner matched all five numbers in Saturday's draw.
The second prize of Dh150,000 was shared by 75 people who each took home Dh2,000 in winnings.
Mahzooz's weekly draw, every Saturday, gives entrants the chance to win the top prize of Dh20m ($5.4 million) by matching all five numbers and a weekly raffle that ensures one person will win at least Dh1m.