Mr Johnson welcomed Mr Akufo-Addo to No 10 Downing Street, as the pair posed for photographs on the steps of the prime minister's official London residence.
"I’m overjoyed to see you as ever," Mr Johnson said to Mr Akufo-Addo.
Mr Johnson did not respond to shouted questions from the media outside asking if Russian President Vladimir Putin was “committing genocide” and if Nato needed to get involved to “prevent further war crimes”.
The prime minister said discussions with Mr Akufo-Addo would include the security situation in Africa and in Europe.
“It’s a great, great pleasure to welcome to London again, because you’re a habitual visitor to No 10, my longstanding friend, President Nana Akufo-Addo of Ghana," Mr Johnson said.
“A great, great friend of this country and I look forward to talking about many issues with you again, now I guess the security situation in Africa and of course in Europe and many, many other issues.”
Mr Akufo-Addo told Mr Johnson he would “bring you up to speed with what’s going on in West Africa”.
The talks came as Mr Akufo-Addo this week launched Destination Ghana, a new tourism initiative for the country after the problems of the coronavirus pandemic.
In January, Ghana’s Ministry of Foreign Affairs denied being involved in talks with the UK about hosting a migrant processing centre.