Ole Gunnar Solskjaer's team staged a remarkable comeback against Atalanta in the Champions League to put themselves not only on top of Group F, but also in the right frame of mind to take on Jurgen Klopp's team.
It was Cristiano Ronaldo who secured victory for United after the knives seemed to be out for manager Solskjaer with his team 2-0 down at half-time at Old Trafford. However Marcus Rashford opened their account eight minutes into the second half to spark a fightback.
Captain Harry Maguire equalised in the 75th minute before Ronaldo rose to head in a Luke Shaw cross to complete 3-2 victory.
United will need every ounce of motivation when they face Liverpool, who are the only unbeaten team this campaign.
What's more, Klopp's team travel to Old Trafford in superb form, having scored at least three goals in each of their last eight away games in all competitions.