The plane landed at 3.40pm at Abu Dhabi International Airport and taxied to a red-carpet welcome.
The El Al flight landed at the VIP terminal where US flags flew alongside the Star of David.
Senior White House adviser Jared Kushner, who is US President Donald Trump's son-in-law and a key architect of Washington's Middle East policy, hailed the historic flight.
Mr Kushner praised Sheikh Mohamed bin Zayed, Crown Prince of Abu Dhabi and Deputy Supreme Commander of the Armed Forces, for his leadership and courage.
Sheikh Mohamed was "truly leading the new Middle East", Mr Kushner said.
"The very few who have been critical of this peace agreement are the ones with a long track record of failure," he said.
The Israeli delegation, which included economists, scientists and planners, underpins the importance Israel places on co-operation with the UAE, one of the few Arab countries with a GDP larger than Israel's.
Israeli officials will meet those from the UAE “in preparation for the signing of co-operation agreements in the civil and economic fields”, Israel said.
Mr Kushner and US National Security Adviser Robert O'Brien accompanied the Israeli delegation, led by National Security Adviser Meir Ben-Shabbat.
The flight was numbered after the UAE's international dialling code, and the return flight, set to leave Abu Dhabi on Tuesday morning, is El Al 972, which is Israel's code.
“I’ve been waiting for this moment since I joined the foreign ministry 20 years ago. The sky is the limit,” Lior Haiat, Israeli Foreign Ministry spokesman, told The National.
Mr Haiat said the accord would not only affect the governments but "each and every citizen in Israel and the Emirates". A ceremony to inaugurate the accord could take place in Washington in a matter of weeks, he said.
Before the flight, Israeli health authorities added the UAE to a list of countries from which Israelis can return without mandatory 14-day coronavirus quarantine.
The arrival of the delegation follows the announcement of the Abraham Accord, a US-mediated deal under which Israel agreed to halt annexation of the occupied Palestinian territories in exchange for normalisation of ties with the UAE.
Israel and the UAE have moved quickly to cement their ties over the past two weeks.
Almost immediately, they opened direct phone lines and Cabinet ministers held friendly phone conversations.
On Saturday, the UAE ended its formal commercial boycott of Israel.
UAE Minister of State for Food Security, Mariam Al Mheiri, and Israel's Minister of Agriculture and Rural Development, Alon Schuster, held an online meeting last Friday, Wam reported.