The graduates included UAE citizens employed by more than 120 federal, local and private sector institutions, Dubai Media Office reported.
Sheikh Mohammed urged the graduates to utilise the skills learnt in the programme to develop new projects and enhance the entities they work for.
The programme was established in 2008 to enhance the capabilities of leaders in different fields so they can spearhead change and build a better future for the country.
It allows participants to gain an understanding of new government trends, flexible leadership and smart decision making.
Sheikh Saif bin Zayed, Deputy Prime Minister and Minister of Interior, and Sheikh Mansour bin Zayed, Deputy Prime Minister and Minister of Presidential Affairs, also attended, along with several government officials.