United will be looking to lift their second trophy of the season after winning the League Cup in February. If they succeed, it will be a memorable effort from manager Erik ten Hag.
An FA Cup victory would complete an impressive debut season at Old Trafford for the Dutchman after guiding his side to Champions League qualification.
Standing in their way are Pep Guardiola's City, who are looking to complete an incredible treble, with the Champions League final against Inter Milan lined up next.
As we prepare for the Manchester showdown, take our quiz below and test your knowledge about United in FA Cup finals over the years.