Syria's first lady Asma Al Assad has “acute myelogenous leukaemia”, the Syrian state news agency, Sana, said on Tuesday.
Ms Al Assad was exhibiting “symptoms and clinical signs” of the disease before medical tests, it said.
The first lady will undergo treatment, including protocols that require her to be isolated and experience “social distancing”, Sana reported.
“She will stay away from direct work and participating in events and activities as part of the treatment plan.”
In 2018, Ms Al Assad was diagnosed with breast cancer after a malignant tumour was discovered, state media reported at the time.
A year later, she announced that she had “fully recovered” from her illness.
“My journey is over, with all its pain and weariness, its drawbacks and even its positives. Praise God, it's over. I have fully triumphed over cancer,” she said at the time, adding that she had been receiving chemotherapy treatment at a Syrian military hospital.
Last year, she accompanied her husband, President Bashar Al Assad, on a visit to the UAE in her first official trip abroad with him since the war began in 2011.
Ms Al Assad, a British-born former investment banker, heads several charities dealing with the families of soldiers killed in the war.
She runs the Syria Trust for Development, an NGO that acts as an umbrella organisation for many of the aid and development operations in the country.
Many Syrians accuse her of being complicit in Assad regime crimes against civilians.
The war has displaced more than 11 million Syrians, creating one of the biggest refugee crises in recent history.
Ms Al Assad was born and raised in London to Syrian parents before returning to Syria after meeting the President.
She married Mr Al Assad in 2000, and the couple has three children.
Squid Game season two
Director: Hwang Dong-hyuk
Stars: Lee Jung-jae, Wi Ha-joon and Lee Byung-hun
Rating: 4.5/5
OIL PLEDGE
At the start of Russia's invasion, IEA member countries held 1.5 billion barrels in public reserves and about 575 million barrels under obligations with industry, according to the agency's website. The two collective actions of the IEA this year of 62.7 million barrels, which was agreed on March 1, and this week's 120 million barrels amount to 9 per cent of total emergency reserves, it added.
Avatar: Fire and Ash
Director: James Cameron
Starring: Sam Worthington, Sigourney Weaver, Zoe Saldana
Rating: 4.5/5
Global state-owned investor ranking by size
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China
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The President's Cake
Director: Hasan Hadi
Starring: Baneen Ahmad Nayyef, Waheed Thabet Khreibat, Sajad Mohamad Qasem
Rating: 4/5
Killing of Qassem Suleimani
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The specs
Engine: 2.0-litre 4cyl turbo
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Torque: 405Nm at 1,750-3,500rpm
Transmission: 9-speed auto
Fuel consumption: 6.9L/100km
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THE BIO
Favourite holiday destination: Whenever I have any free time I always go back to see my family in Caltra, Galway, it’s the only place I can properly relax.
Favourite film: The Way, starring Martin Sheen. It’s about the Camino de Santiago walk from France to Spain.
Personal motto: If something’s meant for you it won’t pass you by.