The UAE confirmed five new cases of the monkeypox virus on Tuesday, taking the total number of infections recorded so far to 13.
The Ministry of Health and Prevention said the cases were detected by "early monitoring and investigation" of the disease.
Hospitals and medical centres in the Emirates have been advised to be on alert for symptoms, which include sores and lesions on the skin.
Confirmed cases will be treated in complete isolation in hospitals until they recover. Any close contact will quarantine at home for 21 days, with monitoring from UAE officials.
Global cases of the virus have now exceeded 1,000.
"Monkeypox is a contagious viral disease, but the ways it is spread are limited compared to the Covid-19 virus," state news agency Wam has reported officials as saying.
"The most prominent ways of transmission of infection from one person to another are through contact with body fluids and respiratory droplets, contact with skin lesions of an infected person, and contact with contaminated surfaces."
Authorities have advised residents to follow all safety and health prevention measures and take preventive measures when travelling and at gatherings.
This includes maintaining personal hygiene and avoiding physical contact with anyone who has skin rashes.
The UAE's first infection was announced on May 24, in a 29-year-old woman from a West African country.
Global health experts do not believe will spread of monkeypox will be anywhere near the scale of Covid-19.
What are the symptoms and how is it treated?
Most monkeypox patients experience fever, body aches, chills and fatigue. People with more serious cases may develop a rash and lesions on the face and hands. The lesions can spread to other parts of the body.
In general, recovery takes about two to four weeks without the need to be admitted to hospital, but monkeypox can be fatal in up to 6 per cent of cases and is thought to be more severe in children.
Smallpox vaccines are effective against monkeypox and antiviral drugs are also being developed.
The World Health Organisation estimates there are thousands of monkeypox infections in about a dozen African countries every year. Most are in Congo, which reports about 6,000 cases annually, and Nigeria, with about 3,000 cases a year.