Fire crews tackled a major blaze in Jebel Ali's industrial area on Wednesday.
Smoke was sent billowing across the district shortly before 2pm.
Dubai Government Media Office said the fire was in a plastics factory and that crews were at the scene.
"Dubai Civil Defence teams and the specialist units succeeded in evacuating the factory of its employees without recording any injuries," it said.
It took about 30 minutes to put out the flames and crews remained at the scene to dampen the damaged building. The cause of the fire has not yet been released.
Drivers on Sheikh Zayed Road drove past thick black fumes coming from the plant when it first ignited.
The area was blocked by police and rescue vehicles remained at the scene.
The Jebel Ali district is home to thousands of companies and hundreds of factories.
The area houses a cluster of plastic factories and it was not clear which the incident took place in. Officials did not name the company.