Manchester United manager Erik ten Hag said forward Antony is "unlikely" to recover from injury in time for Saturday's FA Cup final against Manchester City.
Antony was stretchered off during the first half of last week's Premier League win against Chelsea.
United boss Ten Hag had hoped the Brazilian would be ready to face a rampant City in the first all-Manchester FA Cup final.
But he has made slow progress this week and looks set to be sidelined at Wembley.
"Unlikely (he will be fit)," Ten Hag said on Friday. "Dos Santos (Antony) still has a chance but it's a really small chance.
"He didn't make the progress, so he still has a chance but unlikely he is available."
Anthony Martial's injury-hit season will also end on the sidelines.
Man United 4-1 Chelsea player ratings
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MANCHESTER UNITED PLAYER RATIINGS: David De Gea – 7. Fortunate that Chelsea’s finishing was so poor in the first half following some excellent football. Saved from Hall. Felix shot past him from distance to ruin another clean sheet. Getty -
Aaron Wan Bissaka – 7. Through on goal after 51 but ran into players. Strong going forward. Played well again. Linked up well with Antony before he went off. Reuters -
Victor Lindelof – 8. Up against it as Chelsea dominated possession in the first half. Robbed Gallagher of the ball after the break and set up Sancho for an attack. Passed well all night and easily controlled Fofana. His partnership with Varane is an effective one. AFP -
Raphael Varane – 8. Rarely tested by a poor Chelsea side and didn’t put a foot wrong, but Felix moved to his side with ease before scoring the Chelsea goal. AP -
Luke Shaw – 6. United’s defence had problems in the first half and were much better organised in the second. A shame for Shaw that he went off injured at half time. Getty -
Christian Eriksen – 7. Free kick found his midfield foil Casemiro for the opening goal. His vision makes moves happen. Class. Getty -
Casemiro – 8. Fantastic header where he used the pace on the ball to head past for his seventh goal of the season. Sublime chipped no-look pass to Sancho to set up the second. Man of the match. Again. AFP -
Jadon Sancho – 7. Good feet before losing the ball in a first-half attack. Assisted the second with a smart pass to Martial. Calm. Set Fernandes up after the break. AFP -
Bruno Fernandes – 7. Struck the bar just after the break after a lovely move. Won the penalty having been clipped by Fofana, then made the conversion look easy as he tapped it wide of Kepa. Won a loose ball back on 78. PA -
Antony – 5. Swung a shot wide on 13 and was United’s main attacking threat in the early part of the game before he went down in agony. Stretchered off injured after 29 minutes. A worrying sight. AFP -
Anthony Martial – 6. Poor touch when set up by Antony on 18, although Azpilicueta was coming onto him. Led a 22nd minute break from defence. Got the second at the end of a first half where United hadn’t convinced. AP -
SUBS: Marcus Rashford (Antony 29’) – 8. Ran 80 yards with the ball to set up Fernandes who tried to pull the ball back. Moved into the centre when Martial went off and became the first United player to score 30 in a decade. EPA -
Tyrell Malacia (Shaw 45’) – 6. Booked. AP -
Fred (Eriksen on 70) – 6. Full of energy, as ever. Reuters -
Alejandro Garnacho (Martial on 70) – 7. Livewire as ever, his shot was saved by Kepa and hit the bar on 90 minutes. EPA -
Scott McTominay (Fernandes on 86) – N/A. Almost scored United’s fifth. PA -
CHELSEA PLAYER RATINGS: Kepa Arrizabalaga - 6. Provided a good save to deny Garnacho in the 89th minute. Produced decent saves to deny Rashford and Mctominay in added time. Couldn’t have done more to stop any of the home side’s four goals. Getty -
Cesar Azpilicueta - 6. Did well to get in front of Sancho and make a clearance before he could sort out his feet early in the game. Made his experience count as he went toe to toe with Rashford in a foot race and came out victorious in the second half. EPA -
Lewis Hall - 7. A contender for the Blues’ best player on the night. Should have had an assist in the fourth minute, but Mudryk failed to apply the finish. Brilliant delivery to find Havertz in the 31st minute. Got caught ball-watching in the build-up to Martial’s goal. AP -
Wesley Fofana - 2. Should have done better to stop Casemiro from scoring the opener. Gave away the penalty in the second half after he clipped Fernandes’s heel. At fault for the home side’s fourth as his wayward pass across the face of the penalty area was pounced upon by Fernandes. Getty -
Trevoh Chalobah - 4. Had a tough time dealing with the runs of Martial and Rashford into the penalty area. Never looked assured on the ball and gave United forwards too much space and time on the ball. AFP -
Enzo Fernandes - 7. Chelsea's best player, as he repeatedly picked out teammates in good positions with precise passes. Played in Gallagher with a brilliant pass through a crowded United penalty area. AP -
Conor Gallagher - 6. Excellent first-time pass to find Hall in space in the fourth minute. He had a good chance to bring the away side level on the brink of halftime, but his scuffed effort went wide. EPA -
Carney Chukwuemeka - 6. An encouraging performance in Chelsea’s midfield but a lack of cutting edge from the away side’s attackers frustrated his efforts. Getty -
Noni Madueke - 5. Can’t be accused of not trying, but it wasn’t the best of outings for Chelsea’s January signing. Tried to make things happen but he looked short of ideas. AP -
Mykhailo Mudryk - 4. Another disappointing performance. Missed a glorious chance to open the scoring when he failed to make a proper connection with the ball in the fourth minute. Put De Gea to work with a weak shot just after the restart. EPA -
Kai Havertz - 4. Overhit a pass when he could have played Gallagher through on goal in the ninth minute. He should have at least hit the target with his header when he got on the end of Hall’s cross in the 31st minute. AP -
SUBS: Joao Felix (Havertz 64') - 7. Denied by a Lindelof block in the 70th minute. Grabbed a consolation goal for the Blues with a well-taken effort from the edge of the penalty area. AFP -
Christian Pulisic (Mudryk 64') - 5. Got engaged in a needless scuffle with De Gea a few minutes after coming on. Had two good chances to get on the scoresheet but he couldn’t get his efforts past De Gea. AFP -
Ruben Loftus-Cheek (Chukwuemeka 82') - N/A. Tried to make an impact after coming on, but he lacked the final pass. Reuters -
Hakim Ziyech (Madueka 82') - N/A. Provided the assist for Chelsea's consolation with a simple pass infield. AP -
David Fofana (Gallagher 82') - N/A. Had a chance to test De Gea just after coming on but failed to get past Lindelof. AFP
United defeated Brighton & Hove Albion in the semi-finals on penalties and will be looking to lift their second trophy of the season after winning the League Cup in February.
An FA Cup victory would complete an impressive debut season at Old Trafford for the Dutchman after guiding his side, who finished third, to Champions League qualification for next season.
Ten Hag said they are focused on winning the trophy rather than preventing City from emulating United's historic 1999 feat of doing the treble.
"We want to win a cup, it is not about stopping them, it is about winning the Cup. We have a great opportunity," Ten Hag said.
Meanwhile, City could be close to full strength on Saturday. The champions have had fitness concerns in the build-up to the Wembley showpiece.
Jack Grealish, Kevin De Bruyne, Ruben Dias and Manuel Akanji all missed last weekend's final Premier League game of the season at Brentford for a variety of reasons.
Training for the quartet was also curtailed as City opted not to take risks ahead of what is a momentous period in the club's history with the Champions League final to follow next week.
Manager Pep Guardiola says the whole squad is now looking fit and healthy.
He said: "They've trained well in the last two training sessions. They are all of them, more or less, fine."
One member of City's first-choice XI who will not start, however, is goalkeeper Ederson.
