A nurse holds a syringe of a dose of the AstraZeneca Covid-19 vaccine in Guadalajara, Mexico in April 2022. The drug firm is to cease production of the shots. AFP
A nurse holds a syringe of a dose of the AstraZeneca Covid-19 vaccine in Guadalajara, Mexico in April 2022. The drug firm is to cease production of the shots. AFP
A nurse holds a syringe of a dose of the AstraZeneca Covid-19 vaccine in Guadalajara, Mexico in April 2022. The drug firm is to cease production of the shots. AFP
A nurse holds a syringe of a dose of the AstraZeneca Covid-19 vaccine in Guadalajara, Mexico in April 2022. The drug firm is to cease production of the shots. AFP

AstraZeneca withdraws Covid-19 vaccine due to 'lack of demand'


Gillian Duncan
  • English
  • Arabic

AstraZeneca has begun the worldwide withdrawal of its Covid-19 vaccine due to a “surplus of available updated vaccines” since the pandemic.

The company said it would proceed to withdraw Vaxzevria's marketing authorisations within Europe.

Regulator, the European Medicines Agency, has confirmed the vaccine is no longer authorised for use.

“As multiple, variant Covid-19 vaccines have since been developed there is a surplus of available updated vaccines,” the company said, adding this had led to a decline in demand.

The Anglo-Swedish drugmaker's decision came after a statement to the High Court in London in February confirmed that its vaccine “can, in very rare cases, cause TTS” (Thrombosis with Thrombocytopenia Syndrome), a form of blood clot.

Cases were found in people with a low blood platelet count.

It is estimated that between two and three per 100,000 people who were vaccinated had this adverse effect.

Adam Finn, professor of paediatrics at the University of Bristol and head of the Bristol Children's Vaccine Centre, said the the withdrawal is likely not related to the rare side effect.

He told Radio 4's Today show on Wednesday: "It's turned out that this virus is very agile, and it's evolved away from the original vaccines. So they have in a sense become irrelevant and only the reformulated vaccines are likely to be being used now.

"And of course, we're in a very different place, with almost everyone at the population immune to Sars-CoV-2. So the need for this vaccine I think has evaporated now."

Nevertheless, the relationship between the vaccine and TTS has been known for some time, he said.

AstraZeneca vaccine - in pictures

  • An employee is pictured at the Reference Centre for Special Immunobiologicals (CRIE) of the Federal University of Sao Paulo, Brazil, where the trials of the Oxford/AstraZeneca coronavirus vaccine are conducted. Amanda Perobelli / Reuters
    An employee is pictured at the Reference Centre for Special Immunobiologicals (CRIE) of the Federal University of Sao Paulo, Brazil, where the trials of the Oxford/AstraZeneca coronavirus vaccine are conducted. Amanda Perobelli / Reuters
  • A chemist works at AstraZeneca's Sydney labs after Prime Minister Scott Morrison announced Australians will be among the first in the world to receive a coronavirus disease vaccine, if it proves successful. Dan Himbrechts / Australian Associated Press via Reuters
    A chemist works at AstraZeneca's Sydney labs after Prime Minister Scott Morrison announced Australians will be among the first in the world to receive a coronavirus disease vaccine, if it proves successful. Dan Himbrechts / Australian Associated Press via Reuters
  • AstraZeneca's vaccine was among the furthest along in development. AFP
    AstraZeneca's vaccine was among the furthest along in development. AFP
  • Technicians work at the mAbxience biopharmaceutical company on an experimental coronavirus vaccine developed by Oxford University and the laboratory AstraZeneca in Garin, Argentina. Natacha Pisarenko / AP
    Technicians work at the mAbxience biopharmaceutical company on an experimental coronavirus vaccine developed by Oxford University and the laboratory AstraZeneca in Garin, Argentina. Natacha Pisarenko / AP
  • The single trial volunteer's illness is not seen as a significant setback, despite the publicity surrounding it. Paul Ellis / AFP
    The single trial volunteer's illness is not seen as a significant setback, despite the publicity surrounding it. Paul Ellis / AFP
  • Australian Prime Minister Scott Morrison tours AstraZeneca's Sydney laboratories in September as the government signs a deal with the British-Swedish firm for a supply of a Covid-19 vaccine. EPA
    Australian Prime Minister Scott Morrison tours AstraZeneca's Sydney laboratories in September as the government signs a deal with the British-Swedish firm for a supply of a Covid-19 vaccine. EPA

He added: "It's completely clear that this vaccine and the other one [using] this platform, a viral vector from Johnson & Johnson, was associated with this thrombocytopenic thrombosis syndrome. I think that's been clear for a long time, although perhaps only recently acknowledged.

"But I don't think that's really relevant to this withdrawal. I think the withdrawal of the vaccine is simply reflects the fact that it's no longer useful and so not going to be being used anymore."

The firm's application to withdraw the vaccine was made on March 5 and came into effect on May 7, according to the UK's Daily Telegraph.

Patients who say they were left with permanent health problems and are suing the drug maker, though some cases were recently dropped after being told the presence of a small print warning means their case would probably fail.

Gareth Eve, whose BBC radio presenter wife Lisa Shaw died three weeks after receiving her first dose, is among a number of parties who have pulled out of the High Court legal action.

Award-winning BBC radio presenter Lisa Shaw, who died due to complications from the AstraZeneca Covid-19 vaccine. PA
Award-winning BBC radio presenter Lisa Shaw, who died due to complications from the AstraZeneca Covid-19 vaccine. PA

They were told their claim was unlikely to succeed because a leaflet, handed out at vaccination centres, warned of “extremely rare cases of blood clots with low levels of platelets” after vaccination with the AstraZeneca shot.

It is believed the warning, issued on April 7, 2021, could protect AstraZeneca from cases in which relatives died after receiving vaccines beyond that date.

A dozen families have now dropped out of the legal action as a result.

But more than 50 of relatives of people who received the vaccine before the warning was added are continuing with the lawsuit.

The vaccine, developed with scientists from the University of Oxford, was seen as pivotal given its low cost and the fact it could be stored in a normal fridge rather than super-cold storage.

London-listed AstraZeneca began moving into respiratory syncytial virus vaccines and obesity drugs through several deals last year after a slowdown in growth as Covid-19 medicine sales declined, Reuters reported.

Scientists are still learning much about the effects of Long Covid, which is thought to affect millions of people.

Great hope

The launch of the AstraZeneca vaccine was seen as a milestone in the battle against the Covid-19 pandemic.

The first clinical trial for the vaccine started in January 2020, around the same time when reports of the first cases emerged in China.

It built on previous work to create an adenovirus-based vaccine against the Middle Eastern Respiratory Syndrome (MERS) coronavirus, making it a case of ‘copying and pasting’ the genetic code for the spike protein for the virus that causes Covid into the platform's harmless chimp adenovirus to create the ChAdOx1 nCoV-19 vaccine.

By early February, the lab had tested a lab version of the vaccine in mice, which revealed strong immune responses, suggesting the vaccine would work.

Human volunteers received their first doses in April 2020.

NHS staff administer the Oxford-AstraZeneca Covid-19 coronavirus vaccine in St Helens, United Kingdom. Getty Images
NHS staff administer the Oxford-AstraZeneca Covid-19 coronavirus vaccine in St Helens, United Kingdom. Getty Images

On 23 November 2020, it was announced the vaccine was successful, with 70.4% efficacy in preventing symptomatic Covid more than 14 days after receiving two doses of the vaccine.

"We were involved in Bristol in collaboration with Oxford a number of other centres in doing research on this vaccine and I very clearly remember the day in November 2020, when the results came through. And it turned out that it worked," said Prof Finn.

"And we were able to see very early on that even just one dose of this vaccine was saving many, many lives.

"It was a very remarkable period and we really didn't know what to expect, as it came through. Of course, we've never had the experience of developing a vaccine in such a short period of time. But the truth is, it made an enormous difference. It was what as you said at the beginning was what lifted us out of the catastrophe that was unfolding at the time, combined with the other vaccine from Pfizer."

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UAE currency: the story behind the money in your pockets
MATCH DETAILS

Liverpool 2

Wijnaldum (14), Oxlade-Chamberlain (52)

Genk 1

Samatta (40)

 

In-demand jobs and monthly salaries
  • Technology expert in robotics and automation: Dh20,000 to Dh40,000 
  • Energy engineer: Dh25,000 to Dh30,000 
  • Production engineer: Dh30,000 to Dh40,000 
  • Data-driven supply chain management professional: Dh30,000 to Dh50,000 
  • HR leader: Dh40,000 to Dh60,000 
  • Engineering leader: Dh30,000 to Dh55,000 
  • Project manager: Dh55,000 to Dh65,000 
  • Senior reservoir engineer: Dh40,000 to Dh55,000 
  • Senior drilling engineer: Dh38,000 to Dh46,000 
  • Senior process engineer: Dh28,000 to Dh38,000 
  • Senior maintenance engineer: Dh22,000 to Dh34,000 
  • Field engineer: Dh6,500 to Dh7,500
  • Field supervisor: Dh9,000 to Dh12,000
  • Field operator: Dh5,000 to Dh7,000
MOUNTAINHEAD REVIEW

Starring: Ramy Youssef, Steve Carell, Jason Schwartzman

Director: Jesse Armstrong

Rating: 3.5/5

All%20We%20Imagine%20as%20Light
%3Cp%3E%3Cstrong%3EDirector%3A%20%3C%2Fstrong%3EPayal%20Kapadia%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EStarring%3A%3C%2Fstrong%3E%20Kani%20Kusruti%2C%20Divya%20Prabha%2C%20Chhaya%20Kadam%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3ERating%3A%3C%2Fstrong%3E%204%2F5%3C%2Fp%3E%0A
Other must-tries

Tomato and walnut salad

A lesson in simple, seasonal eating. Wedges of tomato, chunks of cucumber, thinly sliced red onion, coriander or parsley leaves, and perhaps some fresh dill are drizzled with a crushed walnut and garlic dressing. Do consider yourself warned: if you eat this salad in Georgia during the summer months, the tomatoes will be so ripe and flavourful that every tomato you eat from that day forth will taste lacklustre in comparison.

Badrijani nigvzit

A delicious vegetarian snack or starter. It consists of thinly sliced, fried then cooled aubergine smothered with a thick and creamy walnut sauce and folded or rolled. Take note, even though it seems like you should be able to pick these morsels up with your hands, they’re not as durable as they look. A knife and fork is the way to go.

Pkhali

This healthy little dish (a nice antidote to the khachapuri) is usually made with steamed then chopped cabbage, spinach, beetroot or green beans, combined with walnuts, garlic and herbs to make a vegetable pâté or paste. The mix is then often formed into rounds, chilled in the fridge and topped with pomegranate seeds before being served.

The specs

Engine: 3.8-litre, twin-turbo V8

Transmission: eight-speed automatic

Power: 582bhp

Torque: 730Nm

Price: Dh649,000

On sale: now  

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%3Cp%3E%3Cstrong%3ECreator%3A%3C%2Fstrong%3E%20Ramez%20Galal%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EStarring%3A%3C%2Fstrong%3E%20Ramez%20Galal%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EStreaming%20on%3A%20%3C%2Fstrong%3EMBC%20Shahid%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3ERating%3A%20%3C%2Fstrong%3E2.5%2F5%3C%2Fp%3E%0A
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%3Cp%3E%3Cstrong%3ERooh%20Afza%3C%2Fstrong%3E%0D%3Cbr%3E100ml%20contains%20414%20calories%0D%3Cbr%3E%3Cstrong%3ETang%20orange%20drink%3C%2Fstrong%3E%0D%3Cbr%3E100ml%20serving%20contains%20300%20calories%0D%3Cbr%3E%3Cstrong%3ECarob%20beverage%20mix%3C%2Fstrong%3E%0D%3Cbr%3E100ml%20serving%20contains%20about%20300%20calories%0D%3Cbr%3E%3Cstrong%3EQamar%20Al%20Din%20apricot%20drink%3C%2Fstrong%3E%0D%3Cbr%3E100ml%20saving%20contains%2061%20calories%0D%3Cbr%3E%3Cstrong%3EVimto%20fruit%20squash%3C%2Fstrong%3E%0D%3Cbr%3E100ml%20serving%20contains%2030%20calories%3C%2Fp%3E%0A

Fire and Fury
By Michael Wolff,
Henry Holt

Other workplace saving schemes
  • The UAE government announced a retirement savings plan for private and free zone sector employees in 2023.
  • Dubai’s savings retirement scheme for foreign employees working in the emirate’s government and public sector came into effect in 2022.
  • National Bonds unveiled a Golden Pension Scheme in 2022 to help private-sector foreign employees with their financial planning.
  • In April 2021, Hayah Insurance unveiled a workplace savings plan to help UAE employees save for their retirement.
  • Lunate, an Abu Dhabi-based investment manager, has launched a fund that will allow UAE private companies to offer employees investment returns on end-of-service benefits.
TO A LAND UNKNOWN

Director: Mahdi Fleifel

Starring: Mahmoud Bakri, Aram Sabbah, Mohammad Alsurafa

Rating: 4.5/5

F1 The Movie

Starring: Brad Pitt, Damson Idris, Kerry Condon, Javier Bardem

Director: Joseph Kosinski

Rating: 4/5

'The Coddling of the American Mind: How Good Intentions and Bad Ideas are Setting up a Generation for Failure' ​​​​
Greg Lukianoff and Jonathan Haidt, Penguin Randomhouse

Jetour T1 specs

Engine: 2-litre turbocharged

Power: 254hp

Torque: 390Nm

Price: From Dh126,000

Available: Now

Neymar's bio

Total club appearances 411

Total goals scored 241

Appearances for Barca 186

Goals scored for Barca 105

COMPANY%20PROFILE%20
%3Cp%3E%3Cstrong%3EName%3A%3C%2Fstrong%3E%20Haltia.ai%0D%3Cbr%3E%3Cstrong%3EStarted%3A%3C%2Fstrong%3E%202023%0D%3Cbr%3E%3Cstrong%3ECo-founders%3A%3C%2Fstrong%3E%20Arto%20Bendiken%20and%20Talal%20Thabet%0D%3Cbr%3E%3Cstrong%3EBased%3A%3C%2Fstrong%3E%20Dubai%2C%20UAE%0D%3Cbr%3E%3Cstrong%3EIndustry%3A%3C%2Fstrong%3E%20AI%0D%3Cbr%3E%3Cstrong%3ENumber%20of%20employees%3A%3C%2Fstrong%3E%2041%0D%3Cbr%3E%3Cstrong%3EFunding%3A%3C%2Fstrong%3E%20About%20%241.7%20million%0D%3Cbr%3E%3Cstrong%3EInvestors%3A%3C%2Fstrong%3E%20Self%2C%20family%20and%20friends%26nbsp%3B%3C%2Fp%3E%0A
Match info

Uefa Nations League Group B:

England v Spain, Saturday, 11.45pm (UAE)

Brief scores:

Toss: Nepal, chose to field

UAE 153-6: Shaiman (59), Usman (30); Regmi 2-23

Nepal 132-7: Jora 53 not out; Zahoor 2-17

Result: UAE won by 21 runs

Series: UAE lead 1-0

Factfile on Garbine Muguruza:

Name: Garbine Muguruza (ESP)

World ranking: 15 (will rise to 5 on Monday)

Date of birth: October 8, 1993

Place of birth: Caracas, Venezuela

Place of residence: Geneva, Switzerland

Height: 6ft (1.82m)

Career singles titles: 4

Grand Slam titles: 2 (French Open 2016, Wimbledon 2017)

Career prize money: $13,928,719

Fight card

Preliminaries:

Nouredine Samir (UAE) v Sheroz Kholmirzav (UZB); Lucas Porst (SWE) v Ellis Barboza (GBR); Mouhmad Amine Alharar (MAR) v Mohammed Mardi (UAE); Ibrahim Bilal (UAE) v Spyro Besiri (GRE); Aslamjan Ortikov (UZB) v Joshua Ridgwell (GBR)

Main card:

Carlos Prates (BRA) v Dmitry Valent (BLR); Bobirjon Tagiev (UZB) v Valentin Thibaut (FRA); Arthur Meyer (FRA) v Hicham Moujtahid (BEL); Ines Es Salehy (BEL) v Myriame Djedidi (FRA); Craig Coakley (IRE) v Deniz Demirkapu (TUR); Artem Avanesov (ARM) v Badreddine Attif (MAR); Abdulvosid Buranov (RUS) v Akram Hamidi (FRA)

Title card:

Intercontinental Lightweight: Ilyass Habibali (UAE) v Angel Marquez (ESP)

Intercontinental Middleweight: Amine El Moatassime (UAE) v Francesco Iadanza (ITA)

Asian Featherweight: Zakaria El Jamari (UAE) v Phillip Delarmino (PHI)

The Bio

Name: Lynn Davison

Profession: History teacher at Al Yasmina Academy, Abu Dhabi

Children: She has one son, Casey, 28

Hometown: Pontefract, West Yorkshire in the UK

Favourite book: The Alchemist by Paulo Coelho

Favourite Author: CJ Sansom

Favourite holiday destination: Bali

Favourite food: A Sunday roast

Dhadak

Director: Shashank Khaitan

Starring: Janhvi Kapoor, Ishaan Khattar, Ashutosh Rana

Stars: 3

The specs
Engine: 2.0-litre 4-cyl turbo

Power: 201hp at 5,200rpm

Torque: 320Nm at 1,750-4,000rpm

Transmission: 6-speed auto

Fuel consumption: 8.7L/100km

Price: Dh133,900

On sale: now 

PROFILE OF INVYGO

Started: 2018

Founders: Eslam Hussein and Pulkit Ganjoo

Based: Dubai

Sector: Transport

Size: 9 employees

Investment: $1,275,000

Investors: Class 5 Global, Equitrust, Gulf Islamic Investments, Kairos K50 and William Zeqiri

Anghami
Started: December 2011
Co-founders: Elie Habib, Eddy Maroun
Based: Beirut and Dubai
Sector: Entertainment
Size: 85 employees
Stage: Series C
Investors: MEVP, du, Mobily, MBC, Samena Capital

The National Archives, Abu Dhabi

Founded over 50 years ago, the National Archives collects valuable historical material relating to the UAE, and is the oldest and richest archive relating to the Arabian Gulf.

Much of the material can be viewed on line at the Arabian Gulf Digital Archive - https://www.agda.ae/en

The Buckingham Murders

Starring: Kareena Kapoor Khan, Ash Tandon, Prabhleen Sandhu

Director: Hansal Mehta

Rating: 4 / 5

Feeding the thousands for iftar

Six industrial scale vats of 500litres each are used to cook the kanji or broth 

Each vat contains kanji or porridge to feed 1,000 people

The rice porridge is poured into a 500ml plastic box

350 plastic tubs are placed in one container trolley

Each aluminium container trolley weighing 300kg is unloaded by a small crane fitted on a truck

Race card

6.30pm: Emirates Holidays Maiden (TB), Dh82,500 (Dirt), 1,900m
7.05pm: Arabian Adventures Maiden (TB), Dh82,500 (D), 1,200m
7.40pm: Emirates Skywards Handicap (TB), Dh82,500 (D), 1,200m
8.15pm: Emirates Airline Conditions (TB), Dh120,000 (D), 1,400m
8.50pm: Emirates Sky Cargo (TB), Dh92,500 (D)1,400m
9.15pm: Emirates.com (TB), Dh95,000 (D), 2,000m

UAE currency: the story behind the money in your pockets
Updated: May 08, 2024, 9:24 AM