Past infection plus vaccinations gives greater Covid protection, study shows

Coronavirus plus two vaccine doses can give a person as much as 94 per cent protection

A patient receives a PfizerBioNTech shot at a pop-up vaccination centre in a London nightclub. AP

A coronavirus infection gives people who then go on to have two shots of vaccine improved protection, new research suggests.

Past Covid infection, together with being fully vaccinated, increases an individual’s protection against the virus to as much as 94 per cent, according to the Zoe Covid study.

The research found two doses of Oxford/AstraZeneca provided 71 per cent protection against infection up to six months after vaccination, while protection was increased to 90 per cent among those who previously tested positive for the virus.

While two doses of Pfizer/BioNTech vaccine gave 80 per cent protection up to six months after vaccination, that increased to 94 per cent with a previous infection.

Professor Tim Spector, of Kings College London, a lead scientist on the Zoe Covid study, said: “Regardless of which vaccine is administered, this latest research shows that having a natural Covid-19 infection before double vaccination does mean greater protection.

“This is really positive news for overall immunity levels in the UK and means that large numbers of people will have effective and long-lasting protection from Covid-19.

“This is also strong evidence to support the need for vaccination, even for those who have already had Covid-19.”

Drawing on more than 1.2 million test results, the analysis found that a previous infection without vaccination gave 65 per cent protection.

Researchers said this suggested that on average vaccination provides better protection, and the addition of vaccination significantly increases protection.

The study also found that protection from a previous infection alone did not wane for up to 450 days after being infected – independent of vaccination status.

This is unlike vaccine protection, which the Zoe study has previously found starts to wane after three months.

A person receives a Covid-19 Pfizer jab at a pop-up vaccination centre at Westfield Stratford City shopping centre in east London, where TikTok are encouraging young Londoners to get jabbed. Picture date: Saturday October 2, 2021.

According to the researchers, this suggests people who have had two doses on top of a previous infection are likely to maintain higher levels of protection from Covid-19 for longer than those who were not infected prior to their vaccination.

The study used data from vaccines which were logged from December 8 last year to July 31 this year and from infections which occurred between May 26 this year, when the Delta variant became dominant, and July 31 this year.

“When it comes to a booster jab, it’s my opinion that if you’re not in one of the eligible groups for a booster yet, but have a previous infection and two vaccines, you shouldn’t be too worried as your protection will be very high," Prof Spector said.

“It’s likely that there will be high levels of uptake in those who are double vaccinated and are invited for a booster, so it’s more important we focus on those who remain unvaccinated, which is still too high, and we are quickly falling behind the rest of Europe.”

Updated: October 06, 2021, 11:01 PM