Early data from a trial of Moderna's Covid-19 vaccine showed that it produced protective antibodies in a small group of healthy volunteers, the US drug firm said on Monday.
The data are from eight people who took part in a safety trial that kicked off in March as the global pandemic caused by the novel coronavirus was spreading.
In the trial of 45 volunteers, conducted by the National Institute of Allergy and Infectious Diseases, eight volunteers who got two doses of the vaccine produced protective antibodies roughly on par with people who recovered from a natural infection of the coronavirus that causes the Covid-19 illness, the biotechnology company said.
The study, which was not designed to prove the vaccine works, offered an early glimmer of hope that it could provide protection against the virus.
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Coronavirus around the world
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A nun wearing a face mask looks up at the window of Pope Francis' studio overlooking St Peter's square as he appears to give his blessing after the Angelus prayer, at the Vatican. AP Photo -
Pope Francis looks from the window of the Apostolic palace overlooking St Peter's Square before his blessing to faithful. AFP -
People wait for Pope Francis to give his blessing from the window of the Apostolic palace overlooking St Peter's Square. AFP -
Soldiers of the Italian 7th CBRN defence regiment 'Cremona' are deployed to sanitise the San Francesco D'Assisi Cathedral, in Civitavecchia, near Rome, Italy. EPA -
A medical worker taking a swab sample from a child to be tested for Covid-19, in a street in Wuhan, in China's central Hubei province. AFP -
Lydia Hassebroek says hello to her friend Rose through her kitchen window in Brooklyn, New York, US. Reuters -
People sit on the grass in Central Park in New York City, amid the coronavirus pandemic. AFP -
Nurses assigned to the Infectious Diseases Unit at the Kenyatta University Hospital dance during a Zumba class held at the hospital compound in Nairobi. AFP -
Buses are seen parked before reopening to the public after the government eased a nationwide lockdown in Lahore, Pakistan. AFP -
George Washington University graduate Catalina Perez, right, receives a copy of her diploma from neighbour Paula Lytle as they keep a social distance at a surprise graduation party for Perez, who completed her undergraduate studies in International Affairs across the span of 10 years only to miss her commencement due to coronavirus, in Washington, US. Reuters -
Faith healers wear face masks as they perform a healing ritual on worshippers in the town of Mbare in Harare, Zimbabwe. EPA
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Scientists are still trying to understand what level of antibodies will ultimately prove protective against the novel coronavirus, and how long that protection will last.
The vaccine appeared to show a dose response, meaning that people who got higher doses had higher levels of antibodies.
Moderna's vaccine has received the green light to start the second stage of human testing, and last week, US regulators gave the vaccine "fast-track" status to speed up the regulatory review.
Moderna expects to start a larger late-stage trial in July.
"We are investing to scale up manufacturing so we can maximise the number of doses we can produce to help protect as many people as we can from Sars-CoV-2," Moderna chief executive Stephane Bancel said.
There are currently no approved treatments or vaccines for Covid-19, and experts predict a safe and effective vaccine could take 12 to 18 months to develop. The company has signed deals with Swiss contract drugmaker Lonza Group and the US government to produce massive quantities of its vaccine.
The vaccine, mRNA-1273, was also found to be generally safe and well tolerated in the early-stage study, the drug developer said.
One person in the trial experienced redness around the injection site, which was characterised as a "grade 3" side effect. No serious side effects had been reported, the company said.
