Imagine a world where you wake up in the morning and can immediately check the quality of your slumber on a sleep chart.
Imagine a mirror that assesses your retinas for high blood pressure and diabetes, or a toilet that instantly evaluates the state of your insides.
And how about a handheld device that makes 50 instantaneous measurements of your health from one droplet of blood or a tiny detector injected into your blood that circulates non stop, scouting for cancer cells?
Such a world where you can self- diagnose the health problems you have that day or the potential diseases you might develop that month, that year or over a lifetime, is not a fantasy.
According to the US scientist Leroy Hood, a world-renowned visionary, that world will be with us in just 10 years with the first steps towards its initiation already taken.
"In the future we'll all have our genome sequenced early in life and will be able to look at those genomes and make strong predictions about our tendency towards certain diseases. Once we've identified things that are possible then we can prevent them," says Mr Hood, a genomics pioneer and founder of the Institute for Systems Biology in Seattle.
Mr Hood has devoted his life's work to bringing about a revolution in the healthcare system and is finally on the cusp of seeing his efforts come to fruition.
He delivers 60 lectures a year on his vision, even flying half way round the world to Abu Dhabi last week to speak at the city's Intercontinental hotel - an event sponsored by NYU Abu Dhabi Institute - an arm of NYUAD that manages public programmes.
That vision is P4 medicine, a new type of medicine developed over his 40-year career that takes a systems approach to disease, ensuring that healthcare is dealt with on a proactive, rather than a reactive level and treats the individual rather than the masses.
With P4 Medicine - the four P's stand for predictive, personalised, preventative and participatory - in 10 years each of us will have a virtual data cloud of billions of data points and the tools to accurately assess that data to optimise our health and avoid disease.
For example a patient destined to get colon cancer at 40 can have their first colonoscopy at 25 to prevent the condition.
In turn this will help the healthcare industry not only demystify and tackle disease head on but also produce more cost-effective and targeted drug treatments.
How P4 medicine will manifest itself is like a sci-fi adventure. Each of us will have our own genome sequenced and stored on our medical record giving an almost horoscope-like insight into our future health and likelihood of developing certain conditions.
Our blood will then be used "as a window" to constantly assess our wellbeing, with a single drop taken by a handheld device measuring 50 major organs to enable early disease detection.
"If you give patients information, they can change their behaviour in a fundamental way and make themselves healthier. Part of that is education and motivation and seeing that you can make a difference in yourself," explains Mr Hood, the son of an electrical engineer.
The foundations of the vision were laid in 1970 when Mr Hood joined the California Institute of Technology, where he had previously studied, and became involved in the first of what he calls "five paradigm changes" in his career.
Over the course of 23 years, he developed five key technologies, including the DNA gene sequencer, that not only laid the technical foundation for modern molecular biology but were instrumental in ensuring the human genome project - a monumental scientific achievement that deciphered the sequence of human DNA - actually happened.
The project had its skeptics, but Mr Hood believed it was crucial to creating information-based medicine that would ultimately allow the healthcare industry to treat disease at the genetic level.
When the project completed in 2003, it gave him the tools to develop his new approach to medicine.
And all this from an extremely, quiet, modest man whose only overriding characteristic is his utter conviction that his prediction will prevail, even if he is not here to see it.
"If I'm here that would be wonderful and if I'm not, it won't matter," says Mr Hood, who reveals he never talks of his incredible achievements with his wife, two children or five granddaughters. "What I do want to do is make sure it's on a good trajectory to get there."
When you ask him how important he was to the outcome of the human genome project, he, again, underplays his role saying his level of importance is hard to define.
The truth is he attended the project's first meeting in the spring of 1985; he developed the technologies that made it all possible and ran one of the 16 human US genome centres that sequenced the human genome.
"I was there throughout," he says, shrugging his shoulders. "It was a reasonable role."
He took that role a step further when in 2000 he created the Institute for Systems Biology - a centre that takes a cross-disciplinary faculty of biologists, computer scientists, chemists, engineers and physicists and delivers an integration of these different technologies with biology and therefore medicine - an approach that led to the development of P4 medicine.
For a man who has already achieved so much, it appears he has a long way to go before he completes his journey though he is adamant he has no intention of retiring.
Instead, he is extremely active in ensuring his institute forms the strategic partnerships it needs to achieve his vision.
He has the Ohio State Medical School on board and a smaller medical centre with plans to have up to eight major healthcare players involved in two years' time.
On a bigger scale, he has a strategic partnership with Luxembourg, a small European nation that could potentially implement P4 medicine nationwide.
"The US has a very chaotic system and it would be really hard to reform but appropriate small countries offer the chance of doing something on a national basis that could in a five or 10 years be transformational."
He says the Middle East is also full of suitable small nations, adding that his talk last week was a perfect opportunity to introduce the idea to this region - a part of the world he also believes will benefit enormously from family genome sequencing because of the high levels of consanguinity. .
But he admits he alone cannot change the mindset of the global healthcare industry.
Instead, he believes the driving force for medicine to change will be patient-activated social networks.
"Doctors are too conservative. A good example is the triple therapy for Aids - it was Aids activists' who pushed that against the best judgement of the physicians and the pharmaceuticals. That's people power."
Scepticism is probably his biggest enemy. As any great visionary knows, there are a number of hurdles to clear to get a new system in place and for P4 medicine there are not only social implications, but also ethical, regulatory and even legal.
For example how early in a new life do you carry out the genome sequence? To what extent should your data be shared with the world to ensure scientists can analyse it and take it to the next level? And how much do we really want to know about ourselves?
If we're going to develop an incurable disease in 30 years time, is that information we really want access to now?
"Many conditions can't be treated so the question of how much you tell the patient is a matter of enormous debate ," says Mr Hood. "If it was me, I'd want to know, even if you couldn't treat it."
Whatever the hurdles of the future, Mr Hood's work is already proving effective.
"An example of something we've done recently is to develop a biomarker panel that has the exquisite sensitivity for differentiating soldiers that have post traumatic stress disorder (PTSD) from those that don't. For the first time we have a quantitative blood criteria that can say whether a soldier has PTSD or not."
It's a major breakthrough but Mr Hood still needs to convince what he calls "an intrinsically conservative" scientific community that he is right.
"In the human genome project in 1985, I'd say 90 per cent of the biologists were opposed to it. I've run into scepticism and hostility all through my career and in the end you just have to go out and prove you really are going to change the world and that's when the sceptics become believers.
"I think many people believe that much of what I'm talking about will come to pass - they would just put it at 50 years rather than 10 and they are totally wrong. I think 10 years is too long."
arayer@thenational.ae
The finalists
Player of the Century, 2001-2020: Cristiano Ronaldo (Juventus), Lionel Messi (Barcelona), Mohamed Salah (Liverpool), Ronaldinho
Coach of the Century, 2001-2020: Pep Guardiola (Manchester City), Jose Mourinho (Tottenham Hotspur), Zinedine Zidane (Real Madrid), Sir Alex Ferguson
Club of the Century, 2001-2020: Al Ahly (Egypt), Bayern Munich (Germany), Barcelona (Spain), Real Madrid (Spain)
Player of the Year: Cristiano Ronaldo, Lionel Messi, Robert Lewandowski (Bayern Munich)
Club of the Year: Bayern Munich, Liverpool, Real Madrid
Coach of the Year: Gian Piero Gasperini (Atalanta), Hans-Dieter Flick (Bayern Munich), Jurgen Klopp (Liverpool)
Agent of the Century, 2001-2020: Giovanni Branchini, Jorge Mendes, Mino Raiola
Citadel: Honey Bunny first episode
Directors: Raj & DK
Stars: Varun Dhawan, Samantha Ruth Prabhu, Kashvi Majmundar, Kay Kay Menon
Rating: 4/5
Your rights as an employee
The government has taken an increasingly tough line against companies that fail to pay employees on time. Three years ago, the Cabinet passed a decree allowing the government to halt the granting of work permits to companies with wage backlogs.
The new measures passed by the Cabinet in 2016 were an update to the Wage Protection System, which is in place to track whether a company pays its employees on time or not.
If wages are 10 days late, the new measures kick in and the company is alerted it is in breach of labour rules. If wages remain unpaid for a total of 16 days, the authorities can cancel work permits, effectively shutting off operations. Fines of up to Dh5,000 per unpaid employee follow after 60 days.
Despite those measures, late payments remain an issue, particularly in the construction sector. Smaller contractors, such as electrical, plumbing and fit-out businesses, often blame the bigger companies that hire them for wages being late.
The authorities have urged employees to report their companies at the labour ministry or Tawafuq service centres — there are 15 in Abu Dhabi.
Company profile
Date started: December 24, 2018
Founders: Omer Gurel, chief executive and co-founder and Edebali Sener, co-founder and chief technology officer
Based: Dubai Media City
Number of employees: 42 (34 in Dubai and a tech team of eight in Ankara, Turkey)
Sector: ConsumerTech and FinTech
Cashflow: Almost $1 million a year
Funding: Series A funding of $2.5m with Series B plans for May 2020
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The Sand Castle
Director: Matty Brown
Stars: Nadine Labaki, Ziad Bakri, Zain Al Rafeea, Riman Al Rafeea
Rating: 2.5/5
Apple's%20Lockdown%20Mode%20at%20a%20glance
%3Cp%3EAt%20launch%2C%20Lockdown%20Mode%20will%20include%20the%20following%20protections%3A%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EMessages%3A%3C%2Fstrong%3E%20Most%20attachment%20types%20other%20than%20images%20are%20blocked.%20Some%20features%2C%20like%20link%20previews%2C%20are%20disabled%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EWeb%20browsing%3A%3C%2Fstrong%3E%20Certain%20complex%20web%20technologies%2C%20like%20just-in-time%20JavaScript%20compilation%2C%20are%20disabled%20unless%20the%20user%20excludes%20a%20trusted%20site%20from%20Lockdown%20Mode%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EApple%20services%3A%20%3C%2Fstrong%3EIncoming%20invitations%20and%20service%20requests%2C%20including%20FaceTime%20calls%2C%20are%20blocked%20if%20the%20user%20has%20not%20previously%20sent%20the%20initiator%20a%20call%20or%20request%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EConnectivity%3A%3C%2Fstrong%3E%20Wired%20connections%20with%20a%20computer%20or%20accessory%20are%20blocked%20when%20an%20iPhone%20is%20locked%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EConfigurations%3A%3C%2Fstrong%3E%20Configuration%20profiles%20cannot%20be%20installed%2C%20and%20the%20device%20cannot%20enroll%20into%20mobile%20device%20management%20while%20Lockdown%20Mode%20is%20on%3C%2Fp%3E%0A
The specs: 2018 Maserati Ghibli
Price, base / as tested: Dh269,000 / Dh369,000
Engine: 3.0-litre twin-turbocharged V6
Transmission: Eight-speed automatic
Power: 355hp @ 5,500rpm
Torque: 500Nm @ 4,500rpm
Fuel economy, combined: 8.9L / 100km
Dubai Bling season three
Cast: Loujain Adada, Zeina Khoury, Farhana Bodi, Ebraheem Al Samadi, Mona Kattan, and couples Safa & Fahad Siddiqui and DJ Bliss & Danya Mohammed
Rating: 1/5
How to apply for a drone permit
- Individuals must register on UAE Drone app or website using their UAE Pass
- Add all their personal details, including name, nationality, passport number, Emiratis ID, email and phone number
- Upload the training certificate from a centre accredited by the GCAA
- Submit their request
What are the regulations?
- Fly it within visual line of sight
- Never over populated areas
- Ensure maximum flying height of 400 feet (122 metres) above ground level is not crossed
- Users must avoid flying over restricted areas listed on the UAE Drone app
- Only fly the drone during the day, and never at night
- Should have a live feed of the drone flight
- Drones must weigh 5 kg or less
COMPANY PROFILE
Name: Lamsa
Founder: Badr Ward
Launched: 2014
Employees: 60
Based: Abu Dhabi
Sector: EdTech
Funding to date: $15 million
THE BIO
Family: I have three siblings, one older brother (age 25) and two younger sisters, 20 and 13
Favourite book: Asking for my favourite book has to be one of the hardest questions. However a current favourite would be Sidewalk by Mitchell Duneier
Favourite place to travel to: Any walkable city. I also love nature and wildlife
What do you love eating or cooking: I’m constantly in the kitchen. Ever since I changed the way I eat I enjoy choosing and creating what goes into my body. However, nothing can top home cooked food from my parents.
Favorite place to go in the UAE: A quiet beach.
Cricket World Cup League 2 Fixtures
Saturday March 5, UAE v Oman, ICC Academy (all matches start at 9.30am)
Sunday March 6, Oman v Namibia, ICC Academy
Tuesday March 8, UAE v Namibia, ICC Academy
Wednesday March 9, UAE v Oman, ICC Academy
Friday March 11, Oman v Namibia, Sharjah Cricket Stadium
Saturday March 12, UAE v Namibia, Sharjah Cricket Stadium
UAE squad
Ahmed Raza (captain), Chirag Suri, Muhammad Waseem, CP Rizwan, Vriitya Aravind, Asif Khan, Basil Hameed, Rohan Mustafa, Kashif Daud, Zahoor Khan, Junaid Siddique, Karthik Meiyappan, Akif Raja, Rahul Bhatia
Gifts exchanged
- King Charles - replica of President Eisenhower Sword
- Queen Camilla - Tiffany & Co vintage 18-carat gold, diamond and ruby flower brooch
- Donald Trump - hand-bound leather book with Declaration of Independence
- Melania Trump - personalised Anya Hindmarch handbag
Match info
Uefa Champions League Group B
Tottenham Hotspur 1 (Eriksen 80')
Inter Milan 0
MATCH INFO
Austria 2
Hinteregger (53'), Schopf (69')
Germany 1
Ozil (11')
Frankenstein in Baghdad
Ahmed Saadawi
Penguin Press
The Facility’s Versatility
Between the start of the 2020 IPL on September 20, and the end of the Pakistan Super League this coming Thursday, the Zayed Cricket Stadium has had an unprecedented amount of traffic.
Never before has a ground in this country – or perhaps anywhere in the world – had such a volume of major-match cricket.
And yet scoring has remained high, and Abu Dhabi has seen some classic encounters in every format of the game.
October 18, IPL, Kolkata Knight Riders tied with Sunrisers Hyderabad
The two playoff-chasing sides put on 163 apiece, before Kolkata went on to win the Super Over
January 8, ODI, UAE beat Ireland by six wickets
A century by CP Rizwan underpinned one of UAE’s greatest ever wins, as they chased 270 to win with an over to spare
February 6, T10, Northern Warriors beat Delhi Bulls by eight wickets
The final of the T10 was chiefly memorable for a ferocious over of fast bowling from Fidel Edwards to Nicholas Pooran
March 14, Test, Afghanistan beat Zimbabwe by six wickets
Eleven wickets for Rashid Khan, 1,305 runs scored in five days, and a last session finish
June 17, PSL, Islamabad United beat Peshawar Zalmi by 15 runs
Usman Khawaja scored a hundred as Islamabad posted the highest score ever by a Pakistan team in T20 cricket
UFC%20FIGHT%20NIGHT%3A%20SAUDI%20ARABIA%20RESULTS
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MATCH INFO
UAE Division 1
Abu Dhabi Harlequins 12-24 Abu Dhabi Saracens
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Five famous companies founded by teens
There are numerous success stories of teen businesses that were created in college dorm rooms and other modest circumstances. Below are some of the most recognisable names in the industry:
- Facebook: Mark Zuckerberg and his friends started Facebook when he was a 19-year-old Harvard undergraduate.
- Dell: When Michael Dell was an undergraduate student at Texas University in 1984, he started upgrading computers for profit. He starting working full-time on his business when he was 19. Eventually, his company became the Dell Computer Corporation and then Dell Inc.
- Subway: Fred DeLuca opened the first Subway restaurant when he was 17. In 1965, Mr DeLuca needed extra money for college, so he decided to open his own business. Peter Buck, a family friend, lent him $1,000 and together, they opened Pete’s Super Submarines. A few years later, the company was rebranded and called Subway.
- Mashable: In 2005, Pete Cashmore created Mashable in Scotland when he was a teenager. The site was then a technology blog. Over the next few decades, Mr Cashmore has turned Mashable into a global media company.
- Oculus VR: Palmer Luckey founded Oculus VR in June 2012, when he was 19. In August that year, Oculus launched its Kickstarter campaign and raised more than $1 million in three days. Facebook bought Oculus for $2 billion two years later.
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How England have scored their set-piece goals in Russia
Three Penalties
v Panama, Group Stage (Harry Kane)
v Panama, Group Stage (Kane)
v Colombia, Last 16 (Kane)
Four Corners
v Tunisia, Group Stage (Kane, via John Stones header, from Ashley Young corner)
v Tunisia, Group Stage (Kane, via Harry Maguire header, from Kieran Trippier corner)
v Panama, Group Stage (Stones, header, from Trippier corner)
v Sweden, Quarter-Final (Maguire, header, from Young corner)
One Free-Kick
v Panama, Group Stage (Stones, via Jordan Henderson, Kane header, and Raheem Sterling, from Tripper free-kick)
Countries offering golden visas
UK
Innovator Founder Visa is aimed at those who can demonstrate relevant experience in business and sufficient investment funds to set up and scale up a new business in the UK. It offers permanent residence after three years.
Germany
Investing or establishing a business in Germany offers you a residence permit, which eventually leads to citizenship. The investment must meet an economic need and you have to have lived in Germany for five years to become a citizen.
Italy
The scheme is designed for foreign investors committed to making a significant contribution to the economy. Requires a minimum investment of €250,000 which can rise to €2 million.
Switzerland
Residence Programme offers residence to applicants and their families through economic contributions. The applicant must agree to pay an annual lump sum in tax.
Canada
Start-Up Visa Programme allows foreign entrepreneurs the opportunity to create a business in Canada and apply for permanent residence.
Tamkeen's offering
- Option 1: 70% in year 1, 50% in year 2, 30% in year 3
- Option 2: 50% across three years
- Option 3: 30% across five years
PSG's line up
GK: Alphonse Areola (youth academy)
Defence - RB: Dani Alves (free transfer); CB: Marquinhos (€31.4 million); CB: Thiago Silva (€42m); LB: Layvin Kurzawa (€23m)
Midfield - Angel di Maria (€47m); Adrien Rabiot (youth academy); Marco Verratti (€12m)
Forwards - Neymar (€222m); Edinson Cavani (€63m); Kylian Mbappe (initial: loan; to buy: €180m)
Total cost: €440.4m (€620.4m if Mbappe makes permanent move)
Formula Middle East Calendar (Formula Regional and Formula 4)
Round 1: January 17-19, Yas Marina Circuit – Abu Dhabi
Round 2: January 22-23, Yas Marina Circuit – Abu Dhabi
Round 3: February 7-9, Dubai Autodrome – Dubai
Round 4: February 14-16, Yas Marina Circuit – Abu Dhabi
Round 5: February 25-27, Jeddah Corniche Circuit – Saudi Arabia
A list of the animal rescue organisations in the UAE
Engine: 3.5-litre V6
Transmission: eight-speed automatic
Power: 290hp
Torque: 340Nm
Price: Dh155,800
On sale: now
The specs: 2018 Ford Mustang GT
Price, base / as tested: Dh204,750 / Dh241,500
Engine: 5.0-litre V8
Gearbox: 10-speed automatic
Power: 460hp @ 7,000rpm
Torque: 569Nm @ 4,600rpm
Fuel economy, combined: 10.3L / 100km