The Mohammed bin Rashid Space Centre on Sunday said he was due to arrive in the country at around 5.30pm.
A hero's welcome will greet Dr Al Neyadi in Abu Dhabi, with a live media event planned.
People can tune into a live-stream from 5.30pm at mbrsc.ae/live/ and on YouTube.
Dr Al Neyadi returned to Earth on September 4 after a six-month mission that included his science lessons in English and Arabic for young people around the world.
He also carried out a spacewalk to lay cables and insulation on the station.
Since his return two weeks ago, he has been in a recovery programme in Houston, Texas, to help him readapt to gravity.
In a one-minute video posted by Mohammed bin Rashid Space Centre to X, formerly Twitter, Dr Al Neyadi expressed his heartfelt thanks to everyone who helped to make his space mission a success.
“Greetings! And this time from Earth!” he said.
“Thank you so much everybody for the support. We're back and it has been an incredible journey going to space – spending six months aboard the ISS.
“I'm really happy with the achievements we've made,” he said. “It's only the beginning and hopefully we will continue this journey with other people from the UAE and the region.”