Republic of Ireland midfielder Alan Browne has tested positive for coronavirus following Thursday night's 3-0 friendly defeat by England.
Preston North End's Browne, who played the full 90 minutes at Wembley, has been isolated from the rest of the group ahead of Sunday's Nations League fixture against Wales in Cardiff.
However, the PA news agency understands England will be unaffected and will be able to continue their preparations for their own Nations League fixtures against Belgium and Iceland as the Return to Play protocol is designed to legislate for such occurrences.
A Football Association of Ireland statement said: "The Football Association of Ireland can confirm Ireland midfielder Alan Browne has tested positive for Covid-19.
"The player has been isolated from the group as per Covid-19 protocols, and the HSE and UEFA have been informed of this development.
"There are no close contacts of the player and the rest of the staff & squad tested negative ahead of Sunday's Uefa Nations League fixture against Wales in Cardiff."
Browne is the second Ireland player to give a positive result this week, with West Brom striker Callum Robinson having missed the England game for the same reason.
Aaron Connolly and Adam Idah had to sit out last month's Euro 2020 play-off semi-final in Slovakia as close contacts of a member of staff who later tested positive on the flight to Bratislava, while four more players were withdrawn on the squad's return to Dublin.
Wolves captain Connor Coady has been ruled out of England's remaining fixtures during the current international window after after being identified as a close contact to someone who has tested positive for coronavirus via the UK's track and trace programme.
England are due to play Belgium on Sunday in a crucial Nations League encounter, before wrapping up the group stage against Iceland next Wednesday.
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England v Ireland player ratings
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ENGLAND RATINGS: Nick Pope – 6: Didn’t have many saves to make but was a commanding presence in the area, claiming catches and punching to safety when required. Getty -
Reece James - 7: Looked assured and enjoyed his night pushing forward. He’ll feel he did enough to push for a starting place against better opposition. Getty -
Michael Keane – 6: In truth, he had little to do. Was rarely tested in and around his own half. PA -
Harry Maguire – 7: The captain is slowly returning to form and he complemented a solid display with a towering header to open the scoring. EPA -
Tyrone Mings – 6: Mings often opted for the long ball rather than the short pass. Threatened in and around the Ireland area on numerous occasions. Getty -
Bukayo Saka – 6: A decent performance from the Arsenal man who impressed up and down the left flank. His passing let him down, but his crossing was a constant threat. Earned England’s penalty. EPA -
Mason Mount– 7: An energetic performance in a slightly deeper role for the Chelsea midfielder, who linked well with Jack Grealish. Getty -
Harry Winks – 6: Crossed the ball for Maguire to head home and did the simple things well. Slightly overshadowed by Grealish and Mount. AFP -
Jack Grealish – 8: A brilliant performance from a player looking increasingly at home on the international stage. Was England’s most exciting player, always looking to create. AP -
Jadon Sancho – 7: Switched from flank to flank and was most effective when cutting onto his right foot from the left, which is how he doubled England’s lead. EPA -
Dominic Calvert-Lewin – 7: A quiet night in front of goal until he stepped up to finish emphatically from the penalty spot. Worked hard to close down Ireland’s defence. PA -
SUBS: Dean Henderson - (On for Pope 46') 6: Made his debut but had little to do until he saved with his feet at Browne’s expense, and then diving low to his left. Reuters -
Phil Foden - (on for Grealish 61') 5 : Came on to replace Grealish and didn’t have the same impact. In fact, was uncharacteristically quiet. -
Alex Maitland-Niles (On for Mings 61') 5 : Came on as a right wing back but struggled to get into the rhythm of the game. Getty -
Tammy Abraham - (On for Calvert-Lewin 63') 5: A disappointing cameo. Was always in the thick of things but found opportunities hard to come by. AFP -
Jade Bellingham - (On for Mount 73') 7 – Impressed on his first start. Looked comfortable on the ball and totally unfazed by the situation. PA -
IRELAND RATINGS: Darren Randolph - 5: Couldn’t do much about the three goals and though he impressed with a Cruyff turn at Calvert-Lewin’s expense, didn’t inspire confidence. PA -
Matt Doherty - 5: Played at left-back instead of in the centre and struggled to contain Grealish and Sancho. Getty -
Shane Duffy - 5: A poor night for Duffy, who struggled with England’s front three and was outjumped by Harry Maguire for the opener. Getty -
John Egan - 6: Took a blow to the head and was substituted after just 14 minutes. He’d weighed in with some crucial interceptions previously, and Ireland looked worse off for losing his presence. Getty -
Callum O’Dowda - 5: Was full of running but was wasteful in possession. He too often played the ball sideways and backwards. Getty -
Cyrus Christie - 4: A tough night in which he was at fault for England’s second, and then brought down Saka for the penalty that Calvert-Lewin converted. AP -
Conor Hourihane - 5: Came off in the second half after having barely contributed anything going forward. PA -
Jeff Hendrick - 5: Barely threatened England in the final third and instead was guilty of playing too deeply and too conservatively. AP -
Daryl Horgan - 6: Looked tidy until he was replaced. Linked well with Browne and looked to get the ball forward, though he often misplaced it. Getty -
Adam Idah - 5: Needed to show greater urgency but struggled on his own. Ireland looked more threatening when McLean and Curtis came on. EPA -
Alan Browne - 6: One of few Ireland players to come out of the game with any credit. He had Ireland’s first meaningful shot of the game on 72 minutes. PA -
SUBS: Dara O’Shea (On for Egan 14') 6: Did ok when he came on and settled immediately. Had his hands full with England’s rotating front three. -
Robbie Brady (on for Horgan 60') 5: Found it hard to get into the game. A quiet night for the winger. -
James McLean - (On for O'Dowda 61') 5: Was thrown on to try and inject some positivity but couldn’t make an impact in the England half. -
Kevin Long - (On for Christie 61') 5: Seemed to be lacking a bit of sharpness and couldn’t influence the match. PA -
Jayson Molumby - (On for Hourihane 71') 6 – Did very little wrong when he came on. Looked very positive on the ball. PA -
Ronan Curtis -(On for Idah 71') 5: Won his fifth cap but was played in a lone strike role rather this usual position on the wing. Looked lost.
