Manuel Lanzini has suffered a serious knee injury in training, Argentina have said on their official Twitter feed, with the setback ruling him out of play for his side at the World Cup.
The 25-year-old helped West Ham climb the Premier League table in 2018, but is now going to have to sit on the sidelines during the action in Russia.
Argentina said on Twitter on Friday: "Manuel Lanzini suffered, in today's morning training, the rupture of the anterior cruciate ligament of his right knee."
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Lanzini, who scored five goals in 29 appearances for West Ham in 2017-18, has made three appearances for Argentina, scoring his first goal in March's 2-0 victory over Italy.
Argentina, who have won the tournament twice before in 1978 and 1986, are in Group D at Russia 2018, beginning their campaign against Iceland on June 16.
Further fixtures follow with Croatia on June 21 and Nigeria on June 26.
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Bert van Marwijk factfile
Born: May 19 1952
Place of birth: Deventer, Netherlands
Playing position: Midfielder
Teams managed:
1998-2000 Fortuna Sittard
2000-2004 Feyenoord
2004-2006 Borussia Dortmund
2007-2008 Feyenoord
2008-2012 Netherlands
2013-2014 Hamburg
2015-2017 Saudi Arabia
2018 Australia
Major honours (manager):
2001/02 Uefa Cup, Feyenoord
2007/08 KNVB Cup, Feyenoord
World Cup runner-up, Netherlands
COMPANY PROFILE
Founders: Alhaan Ahmed, Alyina Ahmed and Maximo Tettamanzi
Total funding: Self funded
