Manuel Lanzini has suffered a serious knee injury in training, Argentina have said on their official Twitter feed, with the setback ruling him out of play for his side at the World Cup.
The 25-year-old helped West Ham climb the Premier League table in 2018, but is now going to have to sit on the sidelines during the action in Russia.
Argentina said on Twitter on Friday: "Manuel Lanzini suffered, in today's morning training, the rupture of the anterior cruciate ligament of his right knee."
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Lanzini, who scored five goals in 29 appearances for West Ham in 2017-18, has made three appearances for Argentina, scoring his first goal in March's 2-0 victory over Italy.
Argentina, who have won the tournament twice before in 1978 and 1986, are in Group D at Russia 2018, beginning their campaign against Iceland on June 16.
Further fixtures follow with Croatia on June 21 and Nigeria on June 26.
