This week's Premier League action kicks off on Friday with Southampton at home to Bournemouth, but the tie of Matchday 6 looks set to be Sunday's late kick off between Chelsea and Liverpool.
Chelsea and Liverpool both suffered setbacks in midweek Champions League action. Frank Lampard's first match as a manager in Europe's premier club competition ended in a 1-0 defeat at home to Valencia while Liverpool went down 2-0 away to Napoli.
A rare mistake from Virgil van Dijk led to Napoli's second goal and the Dutchman will want to put the horrors of that misplaced pass to Fernando Llorente behind him at Stamford Bridge.
He faces in Tammy Abraham the Premier League's form marksman. The young England striker has netted seven times in the league already this season, including a hat-trick in last week's 5-2 rout of Wolves.
Liverpool are unbeaten in the league though and already have a five-point gap on second-placed Manchester City.
The Premier League champions suffered a shock 3-2 defeat to Norwich City last week. Buoyed by victory at Shakhtar Donetsk in their opening Champions League fixture, however, Pep Guaridola's charges will want to get back to winning ways on the home front against Watford.
Tottenham Hotspur travel to Leicester City in Saturday's early kick off while Burnley host Norwich, Sheffield United travel to Everton and Newcastle United welcome Brighton & Hove Albion.
On Sunday Crystal Palace face Wolves at Selhurst Park while Manchester United are the visitors to West Ham United. Arsenal are at home to Aston Villa before Chelsea take on Liverpool to wrap things up.
Ahead of the games, deputy sports editor Steve Luckings provides his predictions in the photo gallery above.
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