On Tuesday, Salah's Liverpool – 2-0 up from the last-16 first leg – take on Inter Milan at Anfield, while Lewandowski and Bayern Munich face Red Bull Salzburg in Germany after drawing 1-1 last time out.
Wednesday sees Mbappe, Lionel Messi and their Paris Saint-Germain teammates defend their 1-0 first-leg lead against Karim Benzema's Real Madrid in Spain, while Manchester City – 5-0 up from the first game in Portugal – tackle Sporting at the Etihad Stadium.
Last season, Borussia Dortmund's Erling Braut Haaland topped the charts with 10 goals, two ahead of Mbappe, while six players finished with six goals, including Salah and Benzema.
You can see who is leading the way this season – and who is the all-time Champions League/European Cup leading hotshots – in the gallery above. To move on to the next photo, click on the arrows or if using a mobile device, simply swipe.