Premier League predictions: City win Manchester derby, Arsenal close in on top four

We pick out the winners and loser from the latest round of English top-flight fixtures

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  SATURDAY - Leicester v Leeds (4.30pm kick-off UAE): The Marcelo Bielsa reign is over at Leeds and Jesse Marsch begins his tenure with the Yorkshiremen sitting just two points outside the relegation zone. First up for the American coach is a Leicester side boosted by the return of striker Jamie Vardy from injury. Prediction: Leicester 3 Leeds 1. Getty

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  Aston Villa v Southampton (7pm): Much relief for Villa last week when they beat Brighton to secure their first win in three games after taking just one point against top-flight strugglers Leeds, Newcastle and Watford. In-form Southampton are unbeaten since January 15 and sit ninth in the table. Prediction: Villa 1 Southampton 1. Getty

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  Burnley v Chelsea (7pm): Thomas Tuchel's Chelsea will be trying to ignore the ongoing uncertainty over owner Roman Ambramovich's future as they face third-bottom Burnley at Turf Moor. The Clarets' recent mini revival was ended by a midweek defeat at Leicester. Prediction: Burnley 1 Chelsea 2. AFP

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  Newcastle v Brighton (7pm): Joelinton's transformation from laughing stock striker to marauding midfielder has been at the heart of Newcastle's impressive surge away from the drop zone. The Magpies are now up to 14th and take on a Brighton side who have lost three on the trot. Prediction: Newcastle 2 Brighton 0. Getty

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  Norwich v Brentford (7pm): Brentford are on a miserable run of eight games without a win but there was a ray of sunshine last week when Christian Eriksen made his return to football. The Bees take on rock-bottom Norwich who have taken one point from their last four matches. Prediction: Norwich 1 Brentford 0. AFP

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  Wolves v Crystal Palace (7pm): Wolves' Euro aspirations were given a knock by two defeats in four days - against Arsenal and West Ham - as they face another capital club in Palace at Molineux. Palace are sitting comfortably mid-table and secured an FA Cup quarter-final spot by beating Stoke on Tuesday. Prediction: Wolves 1 Palace 1. Reuters

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  Liverpool v West Ham (9.30pm): The League Cup might already be in the bag but Liverpool manager Jurgen Klopp has dismissed talk of an historic trophy quadruple as "crazy". They can reduce Manchester City's lead at the top of the Premier League down to three points with victory here, though. Prediction: Liverpool 3 West Ham 1. Reuters

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  SUNDAY - Watford v Arsenal (6pm): The Gunners could move into a Champions League place, with games in hand on their rivals, if they overcome second-bottom Watford at Vicarage Road. The Hornets are three points form safety having played two matches more than 17th-placed Everton. Prediction: Watford 1 Arsenal 2. Getty

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  Manchester City v Manchester United (8.30pm): Derby day at the Etihad Stadium as City look to maintain their grip on top spot with Liverpool breathing down their necks. United have form for producing surprise wins at the home of their rivals and neighbours but are set to fall short on this occasion. Prediction: City 2 United 1. Reuters

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  MONDAY - Tottenham v Everton (midnight): In the three games since winning at Manchester City, Spurs have lost to struggling Burnley, won 4-0 at Leeds and been knocked out of the FA Cup by second-tier Middlesbrough. Everton are desperate for points after being dragged into the relegation dogfight. Prediction: Spurs 3 Everton 0. Reuters

It is derby weekend in Manchester with City and United clashing at the Etihad Stadium.

When the two teams met in November, City strolled to a 2-0 win at Old Trafford — a defeat that saw United manager Ole Gunner Solskjaer take a big step closer to his exit from the club.

Ralf Rangnick is now in charge of the Red Devils and while their form has been mixed since the German's arrival, United have lost just once in the league and are on target for a Champions League place.

City are top of the pile but have Liverpool threatening to overcome what once seemed like an unstoppable run to retaining their title.

Before that crunch clash, we have a seven-game schedule on Saturday to wade through, starting with Leicester City against Leeds United at the King Power Stadium. Aston Villa then play host to Southampton, Burnley face Chelsea at Turf Moor, Brighton travel north to take on Newcastle, Norwich face Brentford at Carrow Road, while Wolves are at home to Crystal Palace.

Liverpool's clash with West Ham United at Anfield brings the day's proceedings to a close.

On Sunday, Watford tackle Arsenal at Vicarage Road which is followed by the City v United clash, while Tottenham Hotspur are up against Everton on Monday night.

You can see our predictions for this weekend's fixtures in the gallery above. To move on to the next photo, click on the arrows or if using a mobile device, simply swipe.