Premier League predictions: Southampton stun Manchester United, Tottenham tame Wolves

We pick out the winners and losers from this weekend's English top-flight fixtures

SATURDAY - Manchester United v Southampton (4.30pm kick-off UAE): He may have only lost once since taking over but it would be fair to say the appointment of Ralf Rangnick as interim United manager has not exactly had an inspirational effect on players or fans alike. Southampton are on a high after winning at Spurs and are in the sort of form that will add to the frustrations of expectant home fans at Old Trafford. Prediction: United 1 Southampton 2. Reuters

Brentford v Crystal Palace (7pm): Alarm bells are ringing loud and clear at Brentford. Five defeats in a row have left Thomas Frank's side freefalling down into the relegation dogfight. Palace made it draw No 10 this season against Norwich last time out when Wilfried Zaha scored one of the goals of the season while also scuffing an abysmal penalty wide of the target. Prediction: Brentford 1 Palace 1. Reuters

Everton v Leeds (7pm): A clash between two teams who would not have expected to be hovering on the edge of the relegation zone at the start of the season. Leeds' crazy 3-3 draw at Aston Villa on Wednesday was classic a Marcelo Bielsa team performance - fragile at the back but always likely to score goals. Everton lost to Newcastle in midweek - their fourth league defeat in a row - and are very much fighting for their top-flight lives under new manager Frank Lampard. Prediction: Everton 2 Leeds 3. PA

Watford v Brighton (7pm): Watford have brought in Roy Hodgson as manager to try and shore up a leaky defence that has seen them lose more games - 15 - than any other Premier League team this season. Brighton, meanwhile, have drawn more than any other team in the top-flight and are set to make it 13 at Vicarage Road. Prediction: Watford 0 Brighton 0. Reuters

Norwich v Manchester City (9.30pm): Relegation-haunted Canaries have certainly found a bit of form at a vital time, taking seven points out of a possible eight to boost their survival hopes. Alas, not enough of a boost to hold up the Manchester City machine. Their win over over Brentford on Wednesday was victory 19 out of 24 league games this season. Prediction: Norwich 1 City 3. PA

SUNDAY - Burnley v Liverpool (6pm): Bottom club Burnley are unbeaten in three league games, sadly for Sean Dyche's men, all of those ended in draws. The Clarets desperately need to add to their solitary victory this season - but will receive little joy from free-scoring Liverpool. Prediction: Burnley 0 Liverpool 3. Getty

Newcastle v Aston Villa (6pm): An intruiging game at St James' Park between two teams that have been given a lift by their January signings. Newcastle - boosted by the likes of Kieran Trippier and Bruno Guimaraes arriving on Tyneside - are out of the bottom three after beating Everton. Villa, though, could be missing their star loan signing Phillipe Coutinho who is an injury doubt. Prediction: Newcastle 2 Villa 1. Getty

Tottenham v Wolves (6pm): Huge game for Spurs coming on the back on two demoralising league defeats. Losing away to Chelsea might be no surprise, but twice throwing away the lead to lose at home to Southampton on Wednesday, certainly was. They face a Wolves team very much in the mix in the battle for European places. Prediction: Spurs 1 Wolves 0. Reuters

Leicester v West Ham (8.30pm): West Ham climbed back into the top four on Tuesday with a tight win over Watford that, while being far from pretty, showed why they are still fighting with bigger hitters at the top of the table. Leciester are more than capable of winning this but consistency remains a big problem for Brendan Rodgers' side. Prediction: Leicester 2 West Ham 2. Getty

The groundstaff have barely had time to flatten the divots on some pitches and yet here we go straight back into Premier League action.

After the latest round of midweek games, some teams had had little over two days rest before this weekend's fixture list as the top-flight's winter break quickly fades into memory.

Saturday kicks-off with Manchester United against Southampton at Old Trafford, followed by the Brentford v Crystal Palace London derby, Everton's clash with Leeds United on Merseyside and Watford at home to Brighton. Norwich City versus Manchester City brings the day's proceedings to a close.

Sunday starts with Burnley versus Liverpool at Turf Moor, Newcastle United's home game with Aston Villa, Tottenham Hotspur against Wolves in London and finally Leicester City entertaining West Ham United at the King Power Stadium.

You can see out predictions for the latest round of matches in the gallery above. To view the next image, click on the arrows or swipe if on a mobile device.