Premier League predictions: City win Manchester derby, West Ham stun Liverpool

We pick out the winners and losers from the latest round of English top-flight fixtures

FRIDAY - Southampton v Aston Villa (midnight UAE): The managerial spotlight shifts to Dean Smith after Villa slumped to their fourth defeat on the trot last week - a 4-1 home thumping by West Ham. Che Adams' superb strike earned Southampton a 1-0 win at Watford, making it seven points from a possible nine for the Saints. Prediction: Southampton 2 Villa 1. Reuters

SATURDAY - Manchester United v Manchester City (4.30pm): The Cristiano Ronaldo one-man show is back in Manchester for a derby extravaganza. There is no doubting United's attacking threat but the fears of another Liverpool-esque exposing of defensive frailties by City must be lingering in Red Devil minds. Prediction: United 2 City 4. Getty

Brentford v Norwich (7pm): It's been a Premier League reality check for Brentford of late after their impressive start to the season. Three defeats in a row - the last against previously winless Burnley - mean the Bees have dropped down to 12th. But hapless Norwich - with two points on the board - should provide some respite. Prediction: Brentford 3 Norwich 0. Getty

Chelsea v Burnley (7pm): No Timo Werner or Romelu Lukaku for Chelsea - but there's still no stopping the Blues who top the table by three points after four wins on the spin. Burnley finally sealed a victory at the 10th attempt last week on Sean Dyche's ninth anniversary as manager - but the party is over at Stamford Bridge. Prediction: Chelsea 4 Burnley 1. Getty

Crystal Palace v Wolves (7pm): A superlative win for Patrick Vieira's Palace last week when they ran out 2-0 winners at Manchester City, with Wilfried Zaha opening the scoring. Wolves are also flying high after their victory over Everton took them up to the dizzying heights of seventh in the table, four points shy of the top four. Prediction: Palace 1 Wolves 1. PA

Brighton v Newcastle (9.30pm): Whoever is in charge of Newcastle on Saturday, the grim facts are hard to ignore. Second bottom, no wins from 10 and a team slap bang in the middle of a relegation battle. No such problems for Brighton manager Graham Potter whose team are sitting pretty in eighth, with just two defeats all season. Prediction: Brighton 2 Newcastle 0. Getty

SUNDAY - Arsenal v Watford (6pm): Those three defeats at the start of the campaign must feel like a distant memory for Arsenal. Their win at Leicester last week was the Gunners' fifth in seven matches and they are now just three points off the top four. They will fancy their chances against inconsistent Watford. Prediction: Arsenal 3 Watford 1. AFP

Everton v Tottenham (6pm): Antonio Conte is back in charge of a Premier League side for the first time since 2018 looking to lift Spurs - currently in ninth - back towards the top four. The London club should enjoy the new manager bounce against an injury-hit Everton side that has lost three in a row. Prediction: Everton 0 Spurs 2. Getty

Leeds v Leicester (6pm): Neither of these teams are enjoying the best of seasons defensively - conceding 17 goals each - and both have dangerous attacking threats at the other end. All signs point to a high-scoring thriller at Elland Road, with the Foxes edging it. Prediction: Leeds 2 Leicester 3. Getty

West Ham v Liverpool (8.30pm): What a season the Hammers are having, going strong in the league (currently fourth in table), League Cup and Europa League. Liverpool threw away a two-goal lead against Brighton last week and West Ham could be about to cause them more problems here. Prediction: West Ham 2 Liverpool 1. PA

An international break looms on the horizon once again but first there's some big Premier League battles to enjoy.

First up on Friday is Southampton's home game against Aston Villa. Kicking-off the following day is the Manchester derby when United entertain City at Old Trafford, followed by Brentford against Norwich, Chelsea against Burnley and Crystal Palace versus Wolves — all taking place in the capital. Brighton's clash with Newcastle United on the south coast finishes off the day's proceedings.

Sunday sees Arsenal take on Watford at the Emirates Stadium, Everton face Tottenham Hotspur on Merseyside, Leeds United tackle Leicester City in Yorkshire and West Ham United entertain Liverpool at the London Stadium.

You can see our predictions for the latest round of matches in the gallery above. To view the next image, click on the arrows or swipe if on a mobile device.