At least 13 soldiers were killed in an ambush on a desert road near Palmyra in eastern Syria on Sunday, government media service Sana reported.
The news agency said 18 soldiers were also wounded in the attack that involved a variety of weapons.
British-based Syrian Observatory for Human Rights blamed ISIS for the attack and reported the death toll as 15.
Despite the fall of the self-proclaimed ISIS "caliphate" in 2019, the group continues to launch deadly attacks from hideouts in the Syrian desert, which extends from the outskirts of the capital Damascus to the Iraqi border.
The Observatory, which relies on a network of sources across the country, said the death toll could rise as most of the wounded soldiers were in a serious condition.
ISIS did not immediately claim responsibility for the attack.
Syrian soldiers are occasionally moved across country by bus, a high-risk mode of transport given the large concentration of men within a single unarmoured vehicle.
In January, ISIS militants fired rockets and an anti-aircraft gun at a bus travelling in the same area, killing five soldiers.
In October, 27 Syrian soldiers were killed when a bus in Damascus was blown up by two bombs. Two similar attacks in central Syria and in Damascus in January killed eight soldiers.
Palmyra, which has a Unesco World Heritage site that includes Roman ruins, was seized by ISIS in 2015 at the height of the country's civil war.
The city was retaken in March 2016 after Russia's intervention to assist President Bashar Al Assad, only to fall back into ISIS hands in December 2016, before again being recaptured by government forces in January 2017.
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What drives subscription retailing?
Once the domain of newspaper home deliveries, subscription model retailing has combined with e-commerce to permeate myriad products and services.
The concept has grown tremendously around the world and is forecast to thrive further, according to UnivDatos Market Insights’ report on recent and predicted trends in the sector.
The global subscription e-commerce market was valued at $13.2 billion (Dh48.5bn) in 2018. It is forecast to touch $478.2bn in 2025, and include the entertainment, fitness, food, cosmetics, baby care and fashion sectors.
The report says subscription-based services currently constitute “a small trend within e-commerce”. The US hosts almost 70 per cent of recurring plan firms, including leaders Dollar Shave Club, Hello Fresh and Netflix. Walmart and Sephora are among longer established retailers entering the space.
UnivDatos cites younger and affluent urbanites as prime subscription targets, with women currently the largest share of end-users.
That’s expected to remain unchanged until 2025, when women will represent a $246.6bn market share, owing to increasing numbers of start-ups targeting women.
Personal care and beauty occupy the largest chunk of the worldwide subscription e-commerce market, with changing lifestyles, work schedules, customisation and convenience among the chief future drivers.
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