The husband and business partner of designer Kate Spade said she suffered from depression and anxiety for many years.
She was seeking help during the last five years, "seeing a doctor on a regular basis and taking medication for both depression and anxiety," Andy Spade said on Wednesday.
He said there were "personal demons she was battling."
The designer was found hanged in the bedroom of her Park Avenue flat on Tuesday. She was 55 years old and had a 13-year-old daughter. Suicide is suspected.
Spade was working as an accessories editor at Mademoiselle magazine when she launched her company with her husband in their home in 1993.
Andy Spade, the brother of comedian David Spade, said she "sounded happy" the night before her suicide. "There was no indication and no warning that she would do this," he said. "It was a complete shock."
He said he and his wife had been living apart for the past 10 months but saw each other or spoke every day. He said they were not legally separated and never discussed divorce.
Coach, now known as Tapestry, bought the Kate Spade brand last year for $2.4 billion. The couple recently had started a handbag company, Frances Valentine. "We were best friends trying to work through our problems in the best way we knew how," Andy Spade said.