Police and riot teams have been sent to Harmondsworth detention centre in west London following an overnight disturbance.
It occurred after a power cut at the site, a Home Office representative said. No one was injured.
Detainees behind the "violence and disorder" will be held to account, Immigration Minister Robert Jenrick said.
It comes as the Home Office comes under fire over its treatment of migrants and asylum seekers held at detention centres, and Home Secretary Suella Braverman's claim of a migrant "invasion."
Around 100 inmates staged a protest in the courtyard after the power cut, The Guardian reported.
The protest halted a move of about 100 residents to the Manston processing centre in Kent, it added as authorities were preoccupied with the power cut.
No one held at the site is said to have left the premises, known as the Colnbrook immigration removal centre, located close to Heathrow Airport.
"Thankfully no staff working or individuals detained there were hurt, despite clear evidence of unacceptable levels of violence and disorder," Mr Jenrick said.
"The public should be reassured that offenders and others waiting removal from the UK are being held securely.
"The perpetrators of this disturbance will be held to account and, where appropriate, removed from the country as swiftly as is practicable."
In July, a demonstration was held outside the centre over plans to send asylum seekers to Rwanda.
The disturbance comes less than a week after a man threw petrol bombs at a migrant centre in the southern port town of Dover. The suspect was later found dead.
Dover is the focal point of British processing of asylum seekers as the country tries to curb the number of people trying to sail the dangerous English Channel route.
Nearly 40,000 have arrived in the UK so far this year after attempting the treacherous trip from France, crossing one of the world's busiest shipping lanes in dinghies and other small boats.
Conditions at Manston have also drawn ire.
The Refugee Council has called for "urgent action" to tackle conditions at the site, which is holding at least 1,000 people more than its capacity.
The situation in Manston is not what it should be,” Cabinet minister Michael Gove said last week, adding the situation at the centre is "deeply concerning."
MATCH INFO
Fixture: Thailand v UAE, Tuesday, 4pm (UAE)
TV: Abu Dhabi Sports
Why seagrass matters
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MATCH INFO
Manchester United 1 (Rashford 36')
Liverpool 1 (Lallana 84')
Man of the match: Marcus Rashford (Manchester United)
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The specs
Engine: 4.0-litre V8
Power: 503hp at 6,000rpm
Torque: 685Nm at 2,000rpm
Transmission: 8-speed auto
Price: from Dh850,000
On sale: now
Prop idols
Girls full-contact rugby may be in its infancy in the Middle East, but there are already a number of role models for players to look up to.
Sophie Shams (Dubai Exiles mini, England sevens international)
An Emirati student who is blazing a trail in rugby. She first learnt the game at Dubai Exiles and captained her JESS Primary school team. After going to study geophysics at university in the UK, she scored a sensational try in a cup final at Twickenham. She has played for England sevens, and is now contracted to top Premiership club Saracens.
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Seren Gough-Walters (Sharjah Wanderers mini, Wales rugby league international)
Few players anywhere will have taken a more circuitous route to playing rugby on Sky Sports. Gough-Walters was born in Al Wasl Hospital in Dubai, raised in Sharjah, did not take up rugby seriously till she was 15, has a master’s in global governance and ethics, and once worked as an immigration officer at the British Embassy in Abu Dhabi. In the summer of 2021 she played for Wales against England in rugby league, in a match that was broadcast live on TV.
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Erin King (Dubai Hurricanes mini, Ireland sevens international)
Aged five, Australia-born King went to Dubai Hurricanes training at The Sevens with her brothers. She immediately struck up a deep affection for rugby. She returned to the city at the end of last year to play at the Dubai Rugby Sevens in the colours of Ireland in the Women’s World Series tournament on Pitch 1.
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