Swedish scientists hint at the role of alcohol in offences
Is murder in your genes? Scientists in Sweden think it just might be, having identified two that may be partly responsible for extremely violent crimes.
In their study of 794 prisoners in Finland, they found that at least 5 to 10 per cent of the country’s severe violent crimes could be attributed to the genes.
One of the pair is a low-activity version of the monoamine oxidase A (MAOA) gene, which affects feelings, mood and behaviour by altering levels of the brain chemicals dopamine and serotonin.
The other, CDH13, is believed to influence impulsivity.
Low-activity MAOA showed an association with violent crime that increased for extremely violent offenders, while certain CDH13 variants were linked to repeat criminal offences and homicides.
Previous research from Sweden has associated the criminal records of biological parents with violent and non-violent criminality in their adopted children. This suggests that at least some elements of criminality may be genetically inherited.
A rare mutation leading to a complete lack of the MAOA enzyme has also been linked to aggressive behaviour.
The research, led by Dr Jari Tiihonen, from the Karolinska Institute in Sweden, is published online in the journal Molecular Psychiatry.
Summarising their findings, the authors hint at a possible link with alcohol.
They wrote: “A majority of all severe violent crimes in Finland are committed under the influence of alcohol or amphetamine, both of which induce a transient increase in the dopamine levels in the brain.
“Therefore, it is logical to assume that a low dopamine metabolism [breakdown] rate due to low-activity MAOA … may result in higher level of aggression during alcohol or stimulant intoxication.”
Dr Seena Fazel, a senior research fellow at the University of Oxford’s department of psychiatry, said: “This is a potentially interesting study that needs replication in larger cohorts and should also be interpreted cautiously, as recent reviews of MAOA genes have not found clear associations with violence.”
Dr Malcolm von Schantz, a reader in molecular neuroscience at the University of Surrey, asked whether the research could be used by violent criminals to claim diminished responsibility because of the genes that they were born with.
“I think we have to remember that it is becoming increasingly clear that there is not one single genetic variant that has a large effect on this, or indeed any complex behaviour,” he said.
“The pattern that is emerging is one of many genetic factors where each one has a small predisposing effect.”
* Press Association
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