World No 1 and top seed Simona Halep lost a titanic tussle with Chinese Taipei's Su-Wei Hsieh to send her crashing out of Wimbledon in the third round on Saturday.
Despite winning the first set and holding a 5-2 lead in the decider, French Open champion Halep, 26, looked out-of-sorts for much of the match, losing 3-6, 6-4, 7-5 in two hours and 21 minutes
Su will next face Dominika Cibulkova after the Slovakian world No 33 produced an impressive performance to defeat Belgian 15th seed Elise Mertens 6-1, 6-2.
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Halep's exit means Karolina Pliskova is the last remaining top 10 seed in the tournament.
Latvian 12th seed Jelena Ostapenko was in scintillating form to defeat Russian qualifier Vitalia Diatchenko, who beat Maria Sharapova in the first round, 6-0, 6-4 to book her place in the fourth round.
Switzerland's Belinda Bencic continued her return from injury with another fine victory, defeating Spain's world No 26 Carla Suarez Navarro 6-1, 7-6.
Bencic, who reached a career high No 7 in the rankings in 2016 before a succession of injuries halted her progress, defeated sixth seed Caroline Garcia in the first round.
The 21-year-old Swiss will face the winner of German 11th seed Angelique Kerber's match against Japanese 18th seed Naomi Osaka.
Russian 14th seed Daria Kasatkina weathered an early storm against Australian 17th seed to win their third round match 7-5, 6-3, while Dutchwoman Alison Van Uytvanck followed up her stunning victory over defending champion Garbine Muguruza with a 6-2, 6-3 win against Estonia's Anett Kontaveit.