Mounting injuries are the biggest concern for Real Madrid as they take on Shakhtar Donetsk in the Champions League on Tuesday.
Manager Zinedine Zidane had to defend forward Eden Hazard after the forward picked up another injury.
Belgium national team doctor Kris van Crombrugge had suggested Hazard's injury issues since joining Real were down to mental stress. However Zidane refuted those claims.
"He's really strong mentally. It's another injury for him, and it's disappointing for us. These are things that happen in many teams and we need to deal with it," Zidane said.
Hazard joins captain Sergio Ramos, midfielder Federico Valverde, defender Dani Carvajal and forward Luka Jovic on the sidelines.
Real will qualify for the knockout stage with a win over Shakhtar, and will be aiming to avenge their 3-2 defeat by the Ukrainian team in October.
"We know that tomorrow is another final. We've got two left. Tomorrow is almost certainly the most important group stage game because they're three points which could see us qualify. We're fully focused on that."
Real's defensive lapses have seen them ship seven goals in their last three La Liga games and defender Nacho conceded they have to improve.
"We always want to be secure defensively as that's how you win games. The opponents are studying us more and more but you've got to remember that before players we're humans and we try and do the best we can."