Premier League predictions: Jose Mourinho exit inspires Spurs, Manchester United maintain win streak

We pick out the winners and losers from the latest round of top-flight fixtures

WEDNESDAY - Spurs v Southampton (9pm kick-off UAE): An injury to Harry Kane, signing-up for the European Super League, then withdrawing, sacking Jose Mourinho, appointing Ryan Mason as caretaker, league game against the Saints and a League Cup final against Manchester City ... an average week at the office for Spurs who will be aiming for a much-needed lift against Ralph Hasenhuttl's side. Prediction: Spurs 2 Southampton 0. EPA

Gareth Cox

Apr 21, 2021

The shadow of a European Super League might have been looming large this week, but it's still business as usual for the English top-flight.

We have Premier League action every day until a break next week for those not involved in European semi-final fixtures.

Olivier Giroud of Chelsea and Adam Webster of Brighton & Hove Albion battle for the ball during the Premier League match between Chelsea and Brighton & Hove Albion at Stamford Bridge on April 20, 2021 in London, England. Getty Images

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First up on Wednesday is Tottenham Hotspur against Southampton that sees Ryan Mason take charge of Spurs after the sacking of Jose Mourinho, before Aston Villa play host to table-topping Manchester City.

Thursday sees FA Cup finalists Leicester City take on West Bromwich Albion at the King Power Stadium, while on Friday, Arsenal entertain Everton in North London.

Newcastle travel to Merseyside to take on Liverpool on Saturday, while West Ham clash with Chelsea at the London Stadium and relegated Sheffield United face Brighton.

Sunday's action begins with Wolves versus Burnley at Molineux, Leeds against Manchester United in Yorkshire and Aston Villa's midlands derby with West Bromwich Albion.

Ending the latest round of fixtures is Leicester's second home game in four days against Burnley on Monday.

To look through our predictions for the latest round of matches, browse the photo gallery above. To move on to the next photo, click on the arrows, or if using a mobile device simply swipe.