All eyes will be on a blockbusting battle between two of English football's most bitter rivals that takes place on Sunday.
Manchester United, who have just taken over the Premier League top spot from Liverpool after beating Burnley on Tuesday, travel to Merseyside to take on the reigning champions at Anfield.
Paul Pogba, who scored the winner against Burnley, insists the chance to take on Jurgen Klopp's men could not have come at a better time for the in-form Red Devils.
But there is plenty of other action before we get to that clash of the titans. On Thursday night, we have a London derby when Arsenal play host to Crystal Palace.
A hectic Saturday schedule kicks off with a Midlands spat between Wolves and West Bromwich Albion at Molineux, followed by Leeds versus Brighton in Yorkshire. West Ham against Burnley and Fulham versus Chelsea take place in the capital, while Leicester's clash with Southampton at the King Power Stadium completes the day's action.
Sunday starts with Sheffield United versus Tottenham at Bramall Lane, then on to the Liverpool-United game, and finally Manchester City facing Crystal Palace at the Etihad Stadium.
Ahead of the next round of fixtures, check out the predictions in the photo gallery above. To move on to the next photo, click on the arrows or if using a mobile device, simply swipe.