Kevin de Bruyne a doubt for Manchester City's match against Arsenal after withdrawing from Belgium squad

Midfielder substituted in second half of Nations League defeat to England

Kevin De Bruyne takes a shot at goal during Belgium's Uefa Nations League match against England. EPA

Kevin de Bruyne is a doubt for Manchester City's Premier League match with Arsenal on Saturday after the midfielder withdrew from the Belgium squad with injury.

De Bruyne, 29, came off in the 73rd-minute of Belgium's 2-1 Uefa Nations League defeat to England at Wembley on Sunday, and the national team's Twitter account confirmed he would not be available for the next Group B game in Iceland.

"@DeBruyneKev returned to his club. He couldn’t be fit enough to play against Iceland," the tweet said.

After the England match, Belgium manager Roberto Martinez insisted De Bruyne's substitution was "more precaution that we had to avoid [something], he wasn't 100 per cent".

The midfielder has four days to overcome the undisclosed injury, with City facing Arsenal at the Etihad Stadium on Saturday evening. Raheem Sterling, who pulled out of the England squad before the game against Belgium, is also an injury doubt for City.

Belgium trail England by one point at the midway stage in their Nations League group following Sunday's defeat.

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England v Belgium player ratings

ENGLAND RATINGS: Jordan Pickford - 7: Dealt with most things thrown at him and one thumping pass almost put Marcus Rashford through on goal. Reuters

Kyle Walker - 9: The Manchester City defender was ubiquitous on a night he won his 50th cap and his manager's trust again. AFP

Eric Dier - 6: Giving away unnecessary penalties is becoming the Tottenham defender's forte. Reuters

Harry Maguire - 7: He and Dier both struggled against Lukaku's physicality early on but both improved markedly in the second half. AFP

Trent Alexander-Arnold - 6: A subdued performance but provided the only quality ball in open play that led to Mount's winner. Reuters

Declan Rice - 7: Struggled to get the better of the wily Witsel in the first half but dominated the Dortmund man in the second. Reuters

Jordan Henderson - 6: Went down theatrically to win the penalty that levelled the tie. AFP

Kieran Trippier - 7: Looked a square peg in a round hole on the left side of England's defence. Grew into the game though and made some timely interventions. AFP

Mason Mount - 6: A surprise choice ahead of Jack Grealish and did little to justify it before his deflected effort decided the match. Reuters

Marcus Rashford - 6: Another who had a subdued night but banged in a penalty that turned the match in England's favour. AFP

Dominic Calvert-Lewin - 7: Some lovely hold up play with England under the cosh in the first half but precious little to feed on in front of goal. AFP

SUBS: Harry Kane (on for Calvert-Lewin) - 5: Took the sting out of the game drawing fouls off the Belgium defenders but missed an absolute sitter. EPA

Kalvin Phillips (on for Henderson) - 6: The Leeds man does not look out of place on the international stage. EPA

Reece James (on for Alexander-Arnold) - 6: One of four England right-backs to get game time. The Chelsea defender snapped at the heels of Carrasco and Castagne. AFP

Jadon Sancho (on for Mount) - NA: No time to make an impact. AFP

BELGIUM RATINGS: Simon Mignolet - 6: Only playing due a raft of injuries but the Club Bruge man could do nothing about either England goal. AFP

Toby Alderweireld - 7: Hardly troubled and can feel unlucky that Mount's shot looped up off his attempted block for the winner. Reuters

Dedryck Boyata - 7: Solid showing from the Hertha Berlin defender at the heart of Belgium's three-man defence. Reuters

Jason Denayer - 7: Comfortably dealt with most things thrown at him but was caught on his heels as substitute Kane nearly connected with a corner. AFP

Thomas Meunier - 7: Will probably be one of the few players anywhere cursing the absence of VAR after giving away a soft penalty for England's equaliser. Reuters

Youri Tielemans - 6: The 23-year-old will be a linchpin of this Belgium side for years to come but his manager will be concerned how he and midfield partner Witsel wilted once England had the wind in their sails. AFP

Axel Witsel - 6: Looked pure silk until Rice nailed him with a crunching tackle just before half time. Went missing there after. Reuters

Timothy Castagne - 7: Showed why Leicester were prepared to pay big money to bring him to the Premier League. Will be kicking himself for wandering offside that saw Carrasco's early strike ruled out though. AFP

Yannick Carrasco - 8: Belgium's brightest player as they battered England in the first half and was unlucky not to get on the scoresheet before being replaced late on. Reuters

Kevin de Bruyne - 8: The pass that picked out Carrasco in the second half was precision personified. It deserved a better finish. Reuters

Romelu Lukaku - 8: The Inter Milan striker was brute force and subtle flicks in the first half before being snuffed out by England's back three in the second. Reuters

SUBS: Yari Verschaeren (on for De Bruyne) - 5: The 19-year old came on to win a sixth Belgium cap saw little of the ball. Reuters

Jeremy Doku (on for Carrasco) - NB: The Rennes teenager earned a second cap. EPA