US actress Anne Heche is "not expected to survive" after suffering a serious brain injury in a car crash in Los Angeles last week, US media has reported.
The fiery crash left Heche, 53, comatose with a "severe anoxic brain injury", according to a representative quoted by several outlets on Thursday.
"It has long been her choice to donate her organs and she's being kept on life support to determine if any are viable," the statement said.
It also thanked Heche's well-wishers, along with those caring for her at the Grossman Burn Centre at West Hills Hospital.
"Anne had a huge heart and touched everyone she met with her generous spirit," the statement added.
"More than her extraordinary talent, she saw spreading kindness and joy as her life's work — especially moving the needle for acceptance of who you love. She will be remembered for her courageous honesty and dearly missed for her light."
Heche has been comatose since crashing her car into a two-storey house in the Mar Vista neighbourhood on August 5, resulting in "structural compromise and... heavy fire" at the scene, according to the Los Angeles Fire Department.
The ensuing blaze took 59 firefighters 65 minutes to contain and fully extinguish, the department said.
Los Angeles police said in a statement on Thursday that they would be conducting tests of Heche's blood, and that investigators intended to "present this case to the appropriate prosecuting office", though they did not specify a charge.
Local media reported the same day that preliminary tests had come back positive for narcotics, though more were needed to ensure the drugs had not been administered in the course of her treatment.
Celebrity gossip outlet TMZ, citing unnamed police sources, said Heche had tested positive for cocaine and fentanyl, with the latter sometimes used for pain relief in clinical settings.
Heche starred in a number of movies from the 1990s including Six Days, Seven Nights, Donnie Brasco and I Know What You Did Last Summer.
Heche is also known for her role on the soap opera Another World, for which she won a Daytime Emmy in 1991.
During the 1990s, she was in a high-profile relationship with talk show host Ellen DeGeneres.
Scroll through the gallery below to see famous people we've lost in 2022 so far
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Korean actress Kim Mi-soo died aged 29 on January 5, 2022. Photo: Landmark Entertainment -
Actor Sidney Poitier died aged 94 on January 6, 2022. Getty Images -
Director Peter Bogdanovich died aged 82 on January 6, 2022. AP Photo -
Oscar-winning composer Marilyn Bergman, pictured with her husband, Alan Bergman, died aged 93 on January 8, 2022. AP Photo -
American comedian Bob Saget died aged 65 on January 9, 2022. AP Photo -
Actor Gary Waldhorn died aged 78 on January 10, 2022. Getty Images -
Rock 'n' roll singer Ronnie Spector died aged 78 on January 12, 2022. AFP -
Designer Nino Cerruti died aged 91 on January 15, 2022. EPA -
Andre Leon Talley, fashion journalist and former editor-at-large for US Vogue, died aged 73 on January 18, 2022. EPA -
French actor Gaspard Ulliel died aged 37 on January 19, 2022. AFP -
Marvin Lee Aday, better know as the singer Meat Loaf, died aged 74 on January 20, 2022. EPA -
Actor Louie Anderson died aged 68 on January 21, 2022. Reuters -
Vietnamese Zen Buddhist monk Thich Nhat Hanh, died aged 95 on January 22, 2022. EPA -
Director Bassam Al Mulla died aged 66 on January 22, 2022. Photo: Sana -
Fashion designer Thierry Mugler died aged 73 on January 23, 2022. AFP -
Actor Moses J Moseley died aged 31 on January 26, 2022. Photo: Instagram / Moses J Moseley -
Former Miss USA Cheslie Kryst died aged 30 on January 30, 2022. AFP -
Legendary Bollywood singer Lata Mangeshkar died aged 92 on February 6, 2022. AFP -
Funk singer Betty Davis, ex-wife of jazz musician Miles Davis, died aged 77 on February 9, 2022. Photo: Fin Costello / Redferns -
Filmmaker Ivan Reitman died aged 75 on February 12, 2022. Reuters -
American satirist P J O'Rourke died aged 74 on February 15, 2022. AP Photo -
Bollywood singer and composer Bappi Lahiri died aged 69 on February 15, 2022. AFP -
Jordanian-Lebanese sculptor Mona Saudi died aged 76 on February 16, 2022. Photo: Lawrie Shabibi Gallery -
Singer Jane Marczewski, known as Nightbirde, died aged 31 on February 19, 2022. Photo: NBC -
Lebanese singer Sammy Clark died aged 73 on February 20, 2022. Photo: Department of Culture and Tourism - Abu Dhabi -
British entrepreneur and YouTube star Jamal Edwards died aged 31 on February 20, 2022. AP Photo -
Mark Lanegan, of grunge band Screaming Trees, died aged 57 on February 22, 2022. AP Photo -
Children's author and illustrator Shirley Hughes died aged 94 on February 25, 2022. Getty Images -
Australian cricketer Shane Warne died aged 52 on March 4, 2022. AP Photo -
Emilio Delgado, who played fix-it shop owner Luis on Sesame Street, died aged 81 on March 10, 2022. AP Photo -
Actor William Hurt died aged 71 on March 13, 2022. AP -
Pro wrestler Scott Hall, best known for his time in WWE and WCW, died aged 63 on March 14, 2022. Photo: BANG Showbiz -
Ukrainian actress Oksana Shvets died aged 67 on March 17, 2022. Photo: Twitter -
Madeleine Albright, the first woman to serve as US secretary of state, died aged 84 on March 23, 2022. Reuters -
Foo Fighters drummer Taylor Hawkins died aged 50 on March 25, 2022. AFP -
Actor Paul Herman died on his 76th birthday on March 29, 2022. AFP -
British singer Tom Parker died aged 33, on March 30, 2022. AP Photo -
Rock 'n roll star Bobby Rydell and star of the movie musical Bye Bye Birdie, died aged 79, on April 5, 2022. AP Photo -
US actor and comedian Gilbert Gottfried died aged 67 on April 12, 2022. AFP -
US country music star Naomi Judd died aged 76 on April 30, 2022. AP -
South Korean actress Kang Soo-youn died on May 7, 2022, aged 55. EPA -
The late UAE President Sheikh Khalifa bin Zayed, died aged 73 on May 13, 2022. AP Photo / Wam -
US actor Ray Liotta died on May 26, 2022 aged 67. Reuters -
Bollywood singer Krishnakumar Kunnath, known professionally as KK, died aged 53 on May 31, 2022. AFP -
Alec John Such, right, founding member of the group Bon Jovi, died aged 70 on June 4, 2022. Getty Images -
Cooper Noriega, a popular TikTok content creator, died aged 19 on June 9, 2022. Photo: Instagram /@cooper.noriega -
Philip Baker Hall died aged 90 on June 12, 2022. Invision / AP, File -
Actress Mary Mara died aged 61 on June 26, 2022. WireImage -
Theatre and film director Peter Brook died aged 97 on July 2, 2022 -
Manga star and inventor of Yu-Gi-Oh cards, Japanese cartoonist Kazuki Takahashi, died aged 60 on July 4, 2022. EPA -
US actor James Caan of Godfather fame died aged 82 on July 6, 2022. AFP -
Japan's former prime minister Shinzo Abe died aged 67 on July 8, 2022. AP Photo -
Soprano star Tony Sirico, left, died aged 79 on July 8, 2022. AP -
Ivana Trump, Donald Trump's first wife, died aged 73 on July 14, 2022. Reuters -
Pop artist Claes Oldenburg died aged 93 on July 18, 2022. Archive Photos / Getty Images -
Actress Shonka Dukureh died aged 44 on July 21, 2022. Photo: Warner Bros -
Goodfellas actor Paul Sorvino died aged 83 on July 25, 2022 -
US actress Nichelle Nichols died aged 89 on July 30, 2022. Photo: Bettmann / Corbis -
US actress Pat Carroll died aged 95 on July 30, 2022. AFP -
Basketball champion and the first black coach for any US professional sports team Bill Russell died aged 88 on July 31, 2022. AP Photo -
Australian singer Judith Durham died at the age of 79 in Melbourne on August 5, 2022. EPA -
Japanese fashion designer Issey Miyake died aged 84 on August 5, 2022. AFP -
British-Australian singer and actress Olivia Newton-John died aged 73 on August 8, 2022. EPA -
Author and illustrator Raymond Briggs died aged 88 on August 9, 2022. PA -
Actress Anne Heche died aged 53 on August 11, 2022. AP -
Former Pop Idol contestant and theatre star Darius Campbell Danesh died aged 41 on August 11, 2022. PA -
Director Wolfgang Petersen died aged 81 on August 12, 2022. Reuters -
South African actress and model Charlbi Dean Kriek died aged 32 on August 29, 2022. Photo: Invision / AP -
The last leader of the Soviet Union, former president Mikhail Gorbachev, died aged 91 on August 30, 2022. AP Photo / Boris Yurchenko -
British TV presenter and journalist Bill Turnbull died aged 66 on August 31, 2022. PA Media -
Queen Elizabeth II died at 96 on September 8, 2022. Photo: Royal Household / Ranald Mackechnie / PA Wire -
Philadelphia rapper PnB Rock was fatally shot during a robbery aged 30 on September 12, 2022. Photo: Invision / AP, File -
French film director Jean-Luc Godard died at age 91 on September 13, 2022. AFP -
US lawyer and judge Kenneth Starr died aged 76 on September 13, 2022. AFP -
Author Dame Hilary Mantel died aged 70 on September 22, 2022. Getty Images -
American actress Louise Fletcher died aged 88 on September 23, 2022. Photo: AP, File -
Yemeni oud player Ahmed Alshaiba died aged 32 on September 28, 2022. Getty Images -
US rapper Coolio died aged 59 on September 28, 2022. Photo: Brenda Chase Online USA Inc -
US activist Sacheen Littlefeather died aged 75 on October 2, 2022. AFP -
South Korean comic book artist Kim Jung Gi died aged 47 on October 3, 2022. Photo: Kim Jung Gi -
Grammy Award-winning singer Loretta Lynn died at age 90 on October 4, 2022. Getty Images via AFP -
Dame Angela Lansbury died of natural causes aged 96 on October 11, 2022 -
British actor Robbie Coltrane died at the age of 72 on October 14, 2022. PA Media -
Former Pentagon chief Ash Carter died aged 68 on October 24, 2022. EPA -
US actor Leslie Jordan died aged 67 on October 24, 2022. EPA -
Egyptian writer Bahaa Taher died at 87 on October 27, 2022. EPA -
American rock and roll musician Jerry Lee Lewis died aged 87 on October 28, 2022. Reuters -
US rapper Takeoff, born Kirshnik Khari Ball, died aged 28 on November 1, 2022. Photo: Invision / AP, File -
Singer Aaron Carter died aged 34 on November 5, 2022. EPA -
American actor John Aniston, father of Jennifer Aniston, died aged 89 on November 11, 2022. AP Photo -
The Clash guitarist Keith Levene died aged 65 on November 11, 2022. Mirrorpix -
American actor Jason David Frank died aged 49 on November 19, 2022. Photo: Invision / AP -
Latin Grammy-winning balladeer Pablo Milanes died aged 79 on November 22, 2022. AFP -
Fleetwood Mac keyboardist and singer-songwriter Christine McVie died at age 79 on November 30, 2022. Photo: Invision / AP -
Veteran Filipina actress Sylvia La Torre died aged 89 on December 1, 2022. Photo: Facebook -
Actor, musician and children's author Bob McGrath died aged 90 on December 4, 2022. AP Photo -
American actress Kirstie Alley died at aged 71 on December 5, 2022. EPA -
Filipino musician Jovit Baldivino died aged 29 on December 9, 2022. Photo: Jovit Baldivino / Instagram -
Composer Angelo Badalamenti died aged 85 on December 11, 2022. AP -
Stephen 'tWitch' Boss died aged 40 on December 13, 2022. AFP -
Terry Hall, lead singer of The Specials, died aged 63 on December 18, 2022. PA -
Primal Scream and The Charlatans keyboardist Martin Duffy died aged 55 on December 18, 2022. Getty Images -
Maxi Jazz, lead singer of British group Faithless, died aged 65 on December 23, 2022. EPA -
British actor and comedian John Bird died aged 66 on December 24, 2022. PA -
Musician Joseph 'Jo Mersa' Marley, grandson of Bob Marley, died aged 31 on December 27, 2022. Getty Images -
Brazilian football legend Pele died aged 82 on December 29, 2022. Reuters -
British fashion designer Vivienne Westwood died aged 81 on December 29, 2022. Getty Images -
US television journalist Barbara Walters died aged 93 on December 30, 2022. EPA -
Former pope Benedict XVI died aged 95 on December 31, 2022. AFP
