Heard's attorneys are expected to wrap up their questioning of the actress, 36, before turning her over to Depp's legal team for what is expected to be a gruelling cross-examination.
The first four weeks of the multi-million dollar defamation case being heard by a seven-person jury in Fairfax, near Washington, have exposed the couple's volatile relationship in excruciating detail.
In her two days of testimony, a frequently tearful Heard accused Depp of becoming a physically abusive "monster" when he had been drinking and abusing drugs and of being obsessively jealous of her co-stars.
"He hated, hated James Franco," she said.
Depp, during his four days on the witness stand, denied ever striking Heard and claimed she was the one who was frequently violent.
During a particularly heated argument between the couple in Australia, an "irate" Heard severed the tip of one of his fingers by throwing a vodka bottle at him, Depp said.
Heard alleged that Depp sexually assaulted her with a bottle during the fight which occurred in March 2015, a month after their marriage.
He then used blood from his severed finger to write messages on walls and mirrors throughout the home where the couple had been staying during filming of the fifth instalment of the Pirates of the Caribbean franchise, she said.
Closing arguments on May 27
Depp, 58, brought the suit against Heard over an op-ed she wrote for The Washington Post in December 2018 in which she described herself as a "public figure representing domestic abuse".
Heard, who had a starring role in Aquaman, did not name Depp in the op-ed, but he sued her for implying he was a domestic abuser and is seeking $50 million in damages.
The Texas-born Heard countersued, asking for $100m and claiming she suffered "rampant physical violence and abuse" at his hands.
Judge Penney Azcarate has scheduled closing arguments in the case for May 27, after which it will go to the jury.
Depp's lawyers have put experts on the stand who testified that he has lost millions because of the abuse accusations, including a $22.5m for a sixth instalment of Pirates.
Depp filed the defamation complaint in the US after losing a separate libel case in London in November 2020 that he brought against The Sun for calling him a "wife-beater".
Depp, a three-time Oscar nominee, and Heard met in 2009 on the set of The Rum Diary and were married in February 2015. Their divorce was finalised two years later.