Pope Francis says "everything will be different" after the coronavirus pandemic is over.
He has also called for a fairer society and action to "end the pandemic of poverty in the world".
Speaking in Spanish in a video message to mark the feast of Pentecost, the pontiff said there was a duty to build a new reality, particularly for the poorest.
"Once we emerge from this pandemic, we will not be able to keep doing what we were doing and as we were doing it. No, everything will be different," he said on Saturday.
"From the great trials of humanity – among them this pandemic – one emerges better or worse. You don't emerge the same.
"I ask this of you: how do you want to come out of it? Better or worse?"
The pope led a prayer in the Vatican gardens for all those affected by the pandemic, which has killed more than 370,000 people worldwide and devastated the global economy.
On Sunday, he will address worshippers from his window overlooking St Peter's Square for the first time since March, as the Vatican further eases its virus lockdown.
For weeks his traditional Angelus prayer has been live streamed each weekend from inside the Apostolic Palace.
On Saturday, the pope said people needed to open their minds and hearts to learn the central lesson from this crisis.
"We are one humanity. We know it, we knew it, but this pandemic that we are living through has made us experience it in a much more dramatic way," he said.
"All the suffering will be of no use if we do not build together a more just, more equitable, more Christian society, not in name but in reality."