World first stem cell treatment for heart attacks



MADRID // A Spanish hospital has successfully used stem cells taken from healthy donors to treat seven heart-attack victims, in what officials said was a world first.

Gregorio Maranon hospital in Madrid plans to treat 55 patients by using the technique in a clinical trial, according to the regional Madrid government that runs the hospital.

“Seven patients have already been operated on and they have progressed very well despite having suffered serious damage to their heart tissue,” it said.

It is the first time that allogeneic cells, stem cells that come from another person, have been used to repair damage to a heart caused by a heart attack.

A heart attack occurs when the organ is starved of oxygen, such as when a clot blocks the flow of blood to the heart. As the heart heals, the dead muscle is replaced with scar tissue.

But because the scar tissue does not beat like healthy heart muscle, the ability to pump blood around the body is reduced.

Although patients with mild heart failure can live a relatively normal life with the help of drugs, those with severe heart failure can suffer prolonged pain and distress because everyday tasks such as shopping for groceries or taking a shower leave them exhausted.

Doctors around the world are looking at ways of regenerating the heart to replace the scar tissue with beating muscle.

Stem cells figure prominently in their plans, although they have up until now involved the patient’s own stem cells.

While it takes four to eight weeks to process a patient’s own stem cells to be used in therapy, donor cells can be processed and stored and are available for immediate use, according to Dr Francisco Ferandez-Avila, the hospital’s head of cardiology.

“Besides this very important advantage, this technique allows for the selection of donors whose cells show the greatest potential to repair [heart tissue],” he said.

“Before being processed, the allogeneic cells are exhaustively studied and only those that functioned best are selected.”

The cells are injected into the heart through a coronary artery.

The clinical trial is partially financed by the European Union. The hospital is coordinating the study, which involves about 20 European bodies.

* Agence France-Presse

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