How a simple home DNA test unravelled the genetic code that could help prolong my life


Nick Webster
  • English
  • Arabic

Genomics and DNA testing have been hailed as a window into our medical future that could help us live longer, healthier lives.

The first such consumer test available in Dubai, for Dh999, has been trialled to find out exactly what a spit sample can reveal, and what steps should be taken as a result.

Three weeks after a saliva sample was collected by Emirates Post from my home and processed at Dante Labs' $6 million laboratory in Dubai Silicon Oasis, I received a call from the company that my unique genetic profile was ready.

I was invited to meet Alexandra Fonzi, a genomic and molecular biotechnologist at Dante Labs, to discuss my test results.

A little apprehensive about what revelations may be revealed about how my life may end, I was also eager to understand more about my genetics and why my body reacts in certain ways to exercise and diet.

Genetic screening can answer questions such as how some people put on weight, yet others who eat similar foods do not, and why some healthy people get cancer — while other sedentary cigarette smokers live well into old age.

My specific DNA report had a number of different colour codes to indicate analysis.

Green icons showed no area of concern, while yellow markers showed genes that could help in fitness and lifestyle.

  • The $6 million laboratory opened in January and has the capacity to analyse up to 1,000 samples a week. All photos: Pawan Singh / The National
    The $6 million laboratory opened in January and has the capacity to analyse up to 1,000 samples a week. All photos: Pawan Singh / The National
  • Dante chief executive Andrea Riposati showing how the sequencer machine works at Dante Labs, Silicon Oasis in Dubai.
    Dante chief executive Andrea Riposati showing how the sequencer machine works at Dante Labs, Silicon Oasis in Dubai.
  • Home DNA testing is now available in a Dh999 saliva sampling kit provided by the Dante Labs.
    Home DNA testing is now available in a Dh999 saliva sampling kit provided by the Dante Labs.
  • The test kit is part of the wider ‘Genetic for Everybody’ project.
    The test kit is part of the wider ‘Genetic for Everybody’ project.
  • Andrea Riposati said the genetic technology has the potential to transform health care.
    Andrea Riposati said the genetic technology has the potential to transform health care.

Orange alert prompts call for action

An orange flag in my report identified a requirement for action, and a predisposition towards certain illnesses and diseases because of my specific genes.

A blood pressure alert was issued to suggest I was potentially at risk of a heart attack or stroke without changes to my diet, despite regularly exercising, because of the genes I carried.

“You can reduce salt or do more outdoor activities like running to help reduce blood pressure,” said Ms Fonzi, who provides a one-to-one genetic consultation once results are available.

“This information can be passed on to a personal trainer and dietitian to help them develop a personalised plan based on this genetic information.”

Isometric exercises were recommended as the test showed I had a genetically poor response to muscle building, but I was physiologically suited to high-intensity sports and endurance events.

“Without dietary changes, you may experience problems later in life, with high blood pressure you can have issues when you fly for example,” said Ms Fonzi.

“If you notify a doctor, they can help with medication to reduce blood pressure.”

Raising health alarm early

Chief executive Andrea Riposati shows the sequencer machine at Dante Labs, Dubai Silicon Oasis. Pawan Singh / The National
Chief executive Andrea Riposati shows the sequencer machine at Dante Labs, Dubai Silicon Oasis. Pawan Singh / The National

The report is split into two areas, a fitness report showed what injuries I may be predisposed to — in my case tennis elbow and lower back problems, as well as metabolism and genetic markers for disease.

A second report focused on nutrition and revealed what foods could trigger inflammation or digestive problems.

“Glucose intolerance in metabolism is connected to diet, so there is a predisposition that should be addressed by altering your diet to avoid the chances of diabetes in the future,” Ms Fonzi said.

“If we have a high level of oxidative stress, as in your case, you can age earlier and your body will respond differently to someone who does not react to this kind of inflammatory process.”

A Mediterranean-style diet, with whole grains, low-fat dairy products, more vegetables, fruits and fish oils was recommended as the test showed I had a slow lipid metabolism and glucose intolerance.

It meant without regular exercise, I was more likely to put on weight and potentially be at risk of diabetes, while impaired glucose tolerance is a common risk factor for ischaemic heart disease.

“Some genetic traits revealed in the report can help you, with a good response to working out to help you achieve a high level in sport, but you also have a propensity to put on weight if you ceased to exercise,” Ms Fonzi said.

I was also told I was more likely to develop certain injuries, such as shoulder injuries, muscle cramps and arthritis later in life, because of my specific genetic profile.

Cramps could be countered by taking drinks with added sodium and potassium, particularly in the heat, while maintaining a healthy weight could avoid stress on joints in older age, I was told.

Lab technicians working in the Dante Labs at Silicon Oasis in Dubai. Pawan Singh / The National
Lab technicians working in the Dante Labs at Silicon Oasis in Dubai. Pawan Singh / The National

More of a worry was the presence of a specific gene that made me more predisposed to some cancers and cardiovascular disease.

“As you have a high disposition to oxidative stress and carry the A allele gene, if you were a smoker you would be at greater risk of cancer and other cardiovascular disease,” said Ms Fonzi.

“The way your body absorbs HDL cholesterol and fats is also making you at risk of high cholesterol, which is also a hereditary condition in this case as you have an active life.

“It is something that needs to be monitored with regular blood analysis.

“This is a scientific test to you and will give you information as to how you can make your life better in the future by knowing what food you need to avoid, or what nutrition you need to take.”

How genetic testing can transform healthcare

Genetic testing and profiling of patients to predict future care requirements will become a key component of the healthcare strategy in Abu Dhabi, and elsewhere in the GCC.

Thanks to the latest artificial intelligence, G42 Healthcare in Masdar City is one of the leaders in the region, in this kind of medical technology.

At the company’s Biogenix Labs, diagnostic tests or biomarkers help assess high-risk patients and aid in the early detection of diseases, their prognosis, therapy selection, response to treatment, and chances of recurrence.

Thousands of genome sequencing procedures carried out weekly can unlock the possibilities for preventive and precision therapies to transform the UAE healthcare landscape, enabling it to transition from 'sick care' to health care.

G42 Healthcare aims to use the technology to provide insights and facilitate early diagnosis and treatment of cancer, rare and metabolic diseases and other genetic conditions.

“As part of our efforts to support the health of future generations and provide better healthcare every day, Biogenix Labs is expanding its clinical genetics offering in the region and reinforcing its reputation as the regional testing provider of choice,” said Dr Fahed Al Marzooqi, chief operating officer of G42 Healthcare.

“We will soon be expanding this offering to the Kingdom of Saudi Arabia and the wider GCC region as well.”

The specs: 2018 Chevrolet Trailblazer

Price, base / as tested Dh99,000 / Dh132,000

Engine 3.6L V6

Transmission: Six-speed automatic

Power 275hp @ 6,000rpm

Torque 350Nm @ 3,700rpm

Fuel economy combined 12.2L / 100km

GAC GS8 Specs

Engine: 2.0-litre 4cyl turbo

Power: 248hp at 5,200rpm

Torque: 400Nm at 1,750-4,000rpm

Transmission: 8-speed auto

Fuel consumption: 9.1L/100km

On sale: Now

Price: From Dh149,900

Desert Warrior

Starring: Anthony Mackie, Aiysha Hart, Ben Kingsley

Director: Rupert Wyatt

Rating: 3/5

UAE currency: the story behind the money in your pockets
A MINECRAFT MOVIE

Director: Jared Hess

Starring: Jack Black, Jennifer Coolidge, Jason Momoa

Rating: 3/5

MATCH INFO

Uefa Nations League

League A, Group 4
Spain v England, 10.45pm (UAE)

Getting there
Flydubai flies direct from Dubai to Tbilisi from Dh1,025 return including taxes

The National's picks

4.35pm: Tilal Al Khalediah
5.10pm: Continous
5.45pm: Raging Torrent
6.20pm: West Acre
7pm: Flood Zone
7.40pm: Straight No Chaser
8.15pm: Romantic Warrior
8.50pm: Calandogan
9.30pm: Forever Young

Adele: The Stories Behind The Songs
Caroline Sullivan
Carlton Books

How it works

Each player begins with one of the great empires of history, from Julius Caesar's Rome to Ramses of Egypt, spread over Europe and the Middle East.

Round by round, the player expands their empire. The more land they have, the more money they can take from their coffers for each go.

As unruled land and soldiers are acquired, players must feed them. When a player comes up against land held by another army, they can choose to battle for supremacy.

A dice-based battle system is used and players can get the edge on their enemy with by deploying a renowned hero on the battlefield.

Players that lose battles and land will find their coffers dwindle and troops go hungry. The end goal? Global domination of course.

Types of bank fraud

1) Phishing

Fraudsters send an unsolicited email that appears to be from a financial institution or online retailer. The hoax email requests that you provide sensitive information, often by clicking on to a link leading to a fake website.

2) Smishing

The SMS equivalent of phishing. Fraudsters falsify the telephone number through “text spoofing,” so that it appears to be a genuine text from the bank.

3) Vishing

The telephone equivalent of phishing and smishing. Fraudsters may pose as bank staff, police or government officials. They may persuade the consumer to transfer money or divulge personal information.

4) SIM swap

Fraudsters duplicate the SIM of your mobile number without your knowledge or authorisation, allowing them to conduct financial transactions with your bank.

5) Identity theft

Someone illegally obtains your confidential information, through various ways, such as theft of your wallet, bank and utility bill statements, computer intrusion and social networks.

6) Prize scams

Fraudsters claiming to be authorised representatives from well-known organisations (such as Etisalat, du, Dubai Shopping Festival, Expo2020, Lulu Hypermarket etc) contact victims to tell them they have won a cash prize and request them to share confidential banking details to transfer the prize money.

MATCH INFO

Day 2 at Mount Maunganui

England 353

Stokes 91, Denly 74, Southee 4-88

New Zealand 144-4

Williamson 51, S Curran 2-28

Yemen's Bahais and the charges they often face

The Baha'i faith was made known in Yemen in the 19th century, first introduced by an Iranian man named Ali Muhammad Al Shirazi, considered the Herald of the Baha'i faith in 1844.

The Baha'i faith has had a growing number of followers in recent years despite persecution in Yemen and Iran. 

Today, some 2,000 Baha'is reside in Yemen, according to Insaf. 

"The 24 defendants represented by the House of Justice, which has intelligence outfits from the uS and the UK working to carry out an espionage scheme in Yemen under the guise of religion.. aimed to impant and found the Bahai sect on Yemeni soil by bringing foreign Bahais from abroad and homing them in Yemen," the charge sheet said. 

Baha'Ullah, the founder of the Bahai faith, was exiled by the Ottoman Empire in 1868 from Iran to what is now Israel. Now, the Bahai faith's highest governing body, known as the Universal House of Justice, is based in the Israeli city of Haifa, which the Bahais turn towards during prayer. 

The Houthis cite this as collective "evidence" of Bahai "links" to Israel - which the Houthis consider their enemy. 

 

The alternatives

• Founded in 2014, Telr is a payment aggregator and gateway with an office in Silicon Oasis. It’s e-commerce entry plan costs Dh349 monthly (plus VAT). QR codes direct customers to an online payment page and merchants can generate payments through messaging apps.

• Business Bay’s Pallapay claims 40,000-plus active merchants who can invoice customers and receive payment by card. Fees range from 1.99 per cent plus Dh1 per transaction depending on payment method and location, such as online or via UAE mobile.

• Tap started in May 2013 in Kuwait, allowing Middle East businesses to bill, accept, receive and make payments online “easier, faster and smoother” via goSell and goCollect. It supports more than 10,000 merchants. Monthly fees range from US$65-100, plus card charges of 2.75-3.75 per cent and Dh1.2 per sale.

2checkout’s “all-in-one payment gateway and merchant account” accepts payments in 200-plus markets for 2.4-3.9 per cent, plus a Dh1.2-Dh1.8 currency conversion charge. The US provider processes online shop and mobile transactions and has 17,000-plus active digital commerce users.

• PayPal is probably the best-known online goods payment method - usually used for eBay purchases -  but can be used to receive funds, providing everyone’s signed up. Costs from 2.9 per cent plus Dh1.2 per transaction.

Our legal consultant

Name: Hassan Mohsen Elhais

Position: legal consultant with Al Rowaad Advocates and Legal Consultants.

Ferrari 12Cilindri specs

Engine: naturally aspirated 6.5-liter V12

Power: 819hp

Torque: 678Nm at 7,250rpm

Price: From Dh1,700,000

Available: Now

Heavily-sugared soft drinks slip through the tax net

Some popular drinks with high levels of sugar and caffeine have slipped through the fizz drink tax loophole, as they are not carbonated or classed as an energy drink.

Arizona Iced Tea with lemon is one of those beverages, with one 240 millilitre serving offering up 23 grams of sugar - about six teaspoons.

A 680ml can of Arizona Iced Tea costs just Dh6.

Most sports drinks sold in supermarkets were found to contain, on average, five teaspoons of sugar in a 500ml bottle.

RACE CARD

6.30pm: Al Maktoum Challenge Round-3 – Group 1 (PA) $65,000 (Dirt) 2,000m

7.05pm: Handicap (TB) $65,000 (Turf) 1,800m

7.40pm: Meydan Classic – Listed (TB) $88,000 (T) 1,600m

8.15pm: Nad Al Sheba Trophy – Group 3 (TB) $195,000 (T) 2,810m

8.50pm: Dubai Millennium Stakes – Group 3 (TB) $130,000 (T) 2,000m

9.25pm: Meydan Challenge – Listed Handicap (TB) $88,000 (T) 1,400m

Results

5pm: Wathba Stallions Cup Maiden (PA) Dh 70,000 (Dirt) 1,000m, Winner: Hazeem Al Raed, Antonio Fresu (jockey), Ahmed Al Shemaili (trainer)

5.30pm: Handicap (PA) Dh 85,000 (D) 1,000m, Winner: Ghazwan Al Khalediah, Hugo Lebouc, Helal Al Alawi

6pm: Maiden (PA) Dh 70,000 (D) 1,400m, Winner: Dinar Al Khalediah, Patrick Cosgrave, Helal Al Alawi.

6.30pm: Handicap (TB) Dh 70,000 (D) 1,600m, Winner: Faith And Fortune, Sandro Paiva, Ali Rashid Al Raihe.

7pm: Maiden (PA) Dh 70,000 (D) 1,600m, Winner: Only Smoke, Bernardo Pinheiro, Abdallah Al Hammadi.

7.30pm: Handicap (PA) Dh 70,000 (D) 1,600m, Winner: AF Ramz, Saif Al Balushi, Khalifa Al Neyadi.

8pm: Maiden (PA) Dh 70,000 (D) 2,000m, Winner: AF Mass, Tadhg O’Shea, Ernst Oertel.

Our Time Has Come
Alyssa Ayres, Oxford University Press

MATCH INFO

Uefa Champions League final:

Who: Real Madrid v Liverpool
Where: NSC Olimpiyskiy Stadium, Kiev, Ukraine
When: Saturday, May 26, 10.45pm (UAE)
TV: Match on BeIN Sports

Avatar: Fire and Ash

Director: James Cameron

Starring: Sam Worthington, Sigourney Weaver, Zoe Saldana

Rating: 4.5/5

The specs

Engine: 2.0-litre 4-cylinder turbo

Power: 240hp at 5,500rpm

Torque: 390Nm at 3,000rpm

Transmission: eight-speed auto

Price: from Dh122,745

On sale: now

Mercer, the investment consulting arm of US services company Marsh & McLennan, expects its wealth division to at least double its assets under management (AUM) in the Middle East as wealth in the region continues to grow despite economic headwinds, a company official said.

Mercer Wealth, which globally has $160 billion in AUM, plans to boost its AUM in the region to $2-$3bn in the next 2-3 years from the present $1bn, said Yasir AbuShaban, a Dubai-based principal with Mercer Wealth.

Within the next two to three years, we are looking at reaching $2 to $3 billion as a conservative estimate and we do see an opportunity to do so,” said Mr AbuShaban.

Mercer does not directly make investments, but allocates clients’ money they have discretion to, to professional asset managers. They also provide advice to clients.

“We have buying power. We can negotiate on their (client’s) behalf with asset managers to provide them lower fees than they otherwise would have to get on their own,” he added.

Mercer Wealth’s clients include sovereign wealth funds, family offices, and insurance companies among others.

From its office in Dubai, Mercer also looks after Africa, India and Turkey, where they also see opportunity for growth.

Wealth creation in Middle East and Africa (MEA) grew 8.5 per cent to $8.1 trillion last year from $7.5tn in 2015, higher than last year’s global average of 6 per cent and the second-highest growth in a region after Asia-Pacific which grew 9.9 per cent, according to consultancy Boston Consulting Group (BCG). In the region, where wealth grew just 1.9 per cent in 2015 compared with 2014, a pickup in oil prices has helped in wealth generation.

BCG is forecasting MEA wealth will rise to $12tn by 2021, growing at an annual average of 8 per cent.

Drivers of wealth generation in the region will be split evenly between new wealth creation and growth of performance of existing assets, according to BCG.

Another general trend in the region is clients’ looking for a comprehensive approach to investing, according to Mr AbuShaban.

“Institutional investors or some of the families are seeing a slowdown in the available capital they have to invest and in that sense they are looking at optimizing the way they manage their portfolios and making sure they are not investing haphazardly and different parts of their investment are working together,” said Mr AbuShaban.

Some clients also have a higher appetite for risk, given the low interest-rate environment that does not provide enough yield for some institutional investors. These clients are keen to invest in illiquid assets, such as private equity and infrastructure.

“What we have seen is a desire for higher returns in what has been a low-return environment specifically in various fixed income or bonds,” he said.

“In this environment, we have seen a de facto increase in the risk that clients are taking in things like illiquid investments, private equity investments, infrastructure and private debt, those kind of investments were higher illiquidity results in incrementally higher returns.”

The Abu Dhabi Investment Authority, one of the largest sovereign wealth funds, said in its 2016 report that has gradually increased its exposure in direct private equity and private credit transactions, mainly in Asian markets and especially in China and India. The authority’s private equity department focused on structured equities owing to “their defensive characteristics.”

A timeline of the Historical Dictionary of the Arabic Language
  • 2018: Formal work begins
  • November 2021: First 17 volumes launched 
  • November 2022: Additional 19 volumes released
  • October 2023: Another 31 volumes released
  • November 2024: All 127 volumes completed
Getting there

The flights

Emirates and Etihad fly to Johannesburg or Cape Town daily. Flights cost from about Dh3,325, with a flying time of 8hours and 15 minutes. From there, fly South African Airlines or Air Namibia to Namibia’s Windhoek Hosea Kutako International Airport, for about Dh850. Flying time is 2 hours.

The stay

Wilderness Little Kulala offers stays from £460 (Dh2,135) per person, per night. It is one of seven Wilderness Safari lodges in Namibia; www.wilderness-safaris.com.

Skeleton Coast Safaris’ four-day adventure involves joining a very small group in a private plane, flying to some of the remotest areas in the world, with each night spent at a different camp. It costs from US$8,335.30 (Dh30,611); www.skeletoncoastsafaris.com

ALL THE RESULTS

Bantamweight

Siyovush Gulmomdov (TJK) bt Rey Nacionales (PHI) by decision.

Lightweight

Alexandru Chitoran (ROU) bt Hussein Fakhir Abed (SYR) by submission.

Catch 74kg

Omar Hussein (JOR) bt Tohir Zhuraev (TJK) by decision.

Strawweight (Female)

Seo Ye-dam (KOR) bt Weronika Zygmunt (POL) by decision.

Featherweight

Kaan Ofli (TUR) bt Walid Laidi (ALG) by TKO.

Lightweight

Abdulla Al Bousheiri (KUW) bt Leandro Martins (BRA) by TKO.

Welterweight

Ahmad Labban (LEB) bt Sofiane Benchohra (ALG) by TKO.

Bantamweight

Jaures Dea (CAM) v Nawras Abzakh (JOR) no contest.

Lightweight

Mohammed Yahya (UAE) bt Glen Ranillo (PHI) by TKO round 1.

Lightweight

Alan Omer (GER) bt Aidan Aguilera (AUS) by TKO round 1.

Welterweight

Mounir Lazzez (TUN) bt Sasha Palatkinov (HKG) by TKO round 1.

Featherweight title bout

Romando Dy (PHI) v Lee Do-gyeom (KOR) by KO round 1.

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Short-term let permits explained

Homeowners and tenants are allowed to list their properties for rental by registering through the Dubai Tourism website to obtain a permit.

Tenants also require a letter of no objection from their landlord before being allowed to list the property.

There is a cost of Dh1,590 before starting the process, with an additional licence fee of Dh300 per bedroom being rented in your home for the duration of the rental, which ranges from three months to a year.

Anyone hoping to list a property for rental must also provide a copy of their title deeds and Ejari, as well as their Emirates ID.

Women's Prize for Fiction shortlist

The Silence of the Girls by Pat Barker

My Sister, the Serial Killer by Oyinkan Braithwaite

Milkman by Anna Burns

Ordinary People by Diana Evans

An American Marriage by Tayari Jones

Circe by Madeline Miller

Our family matters legal consultant

Name: Hassan Mohsen Elhais

Position: legal consultant with Al Rowaad Advocates and Legal Consultants.

The Bio

Amal likes watching Japanese animation movies and Manga - her favourite is The Ancient Magus Bride

She is the eldest of 11 children, and has four brothers and six sisters.

Her dream is to meet with all of her friends online from around the world who supported her work throughout the years

Her favourite meal is pizza and stuffed vine leaves

She ams to improve her English and learn Japanese, which many animated programmes originate in

What is safeguarding?

“Safeguarding, not just in sport, but in all walks of life, is making sure that policies are put in place that make sure your child is safe; when they attend a football club, a tennis club, that there are welfare officers at clubs who are qualified to a standard to make sure your child is safe in that environment,” Derek Bell explains.

Updated: August 14, 2022, 4:54 AM