Abu Dhabi cancer breakthrough could pave way for chemotherapy alternative

Scientists at the Abu Dhabi Stem Cells Centre have hailed a significant breakthrough in cancer treatment that is primed to improve patient care and strike a crucial blow in the fight against the disease. The centre's team have achieved a medical milestone by isolating tumour-infiltrating lymphocytes (TILs) from breast and lung cancers for the first time in the UAE , state news agency Wam reported. The treatment could serve as an alternative to chemotherapy, which affects healthy and cancerous cells. TIL therapy involves extracting immune cells from a tumour sample, multiplying them in a controlled laboratory environment and administering them to the patient to attack cancer cells directly. This is set to enable the centre to launch the country's first programme dedicated to developing TIL therapy. This form of immunotherapy uses a patient’s own immune cells to target and destroy cancer and the project represents a new era in personalised medicine, Wam said. The therapy turns a patient’s tumour into a personalised cancer-fighting system, serving it as a “living therapy tailored to the individual”, said Dr Zaima Mazorra Herrera, a lead scientist at the Abu Dhabi Stem Cells Centre. "Patients with advanced or treatment-resistant tumors often hear, 'We’ve tried everything'. What TILs offer is a new line of attack that is more specific to the line of tumors that we are targeting. "We are taking the T cells that already know how to recognise that specific cancer and giving them the numbers and strength to matter clinically. "For some patients globally, this has led to tumor shrinkage even after standard therapies failed. Our ambition is to offer that level of possibility here, where 'no more options' is no longer the final conversation." The approach has shown promising results in treating melanoma and offers some hope for patients with advanced solid tumours, including lung, cervical and head and neck cancers. Building this expertise locally eliminates the need for patients to travel abroad for treatment and contributes vital research data to the global scientific community, said Prof Yendry Ventura, the centre's chief executive. The centre, which opened in December 2019, has been central to the UAE's efforts to embrace innovation and advanced technology to enhance health services. The facility has delivered essential support over the years to patients facing a serious conditions including multiple sclerosis and various forms of cancer. In May, The National told of how researchers at the stem cell centre had received encouraging results in their work to find a cure for Type 1 diabetes . The most promising development is focused on regenerating the pancreas using stem cells and is part of a collaboration with Kyoto University and research company Rege Nephro. “We’re very optimistic that in the next couple of years, we’ll have something solid to offer patients,” Prof Ventura said at the time. “This isn’t just stem cell therapy – it’s an approach to regenerate the pancreas itself using a specific type of engineered cell.”

Abu Dhabi cancer breakthrough could pave way for chemotherapy alternative

Abu Dhabi Stem Cells Centre study may herald new era of personalised medicine

Abu Dhabi Stem Cell Centre - in pictures

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