Emirates will fly its A380 superjumbo four times a day between Dubai and London Heathrow from November 27.
The airline is also set to operate its most popular wide-body aircraft six times a week from Dubai to Manchester, beginning December 2.
The move comes after the UK announced an air corridor with the UAE, meaning travellers entering the UK from the UAE are no longer required to quarantine. Emirates said this has "led to increased demand".
The airline is also expanding its regional services across the UK. From Friday, November 27, the airline will add three more flights on the Dubai to Birmingham route, making the service daily.
It will do the same on its only operating route to Scotland, increasing flights to a daily service from Dubai to Glasgow on Tuesday, December 1.
In addition to the boosted A380 services to Manchester, Emirates will add four Boeing 777-300 flights to the schedule, meaning there will be 10 flights per week between Dubai and Manchester from Tuesday, December 1.
At London Heathrow, the current twice-daily A380 and once-daily Boeing 777 flight are replaced by the newly announced four-daily A380 services. With space for more than 400 passengers on each jet, this allows Emirates to offer more tickets between the UK's capital and Dubai in the lead-up to Christmas.
In-flight showers and takeaway bars
As passenger demand increases, Emirates will gradually launch more A380 services across the jet's spacious cabins and double-decker design.
On-board lounge and shower spa services are back on the menu on A380 flights with enhanced safety measures in place to help prevent the spread of Covid-19.
Daily A380 flights to Moscow
Elsewhere, Emirates will up its A380 services to Moscow. The airline currently operates a twice-weekly superjumbo flight to the Russian capital. From Wednesday, November 25, this service will operate daily.
Emirates says this is to "meet increased demand from travellers seeking to holiday in Dubai, or at popular island destinations within easy reach through Dubai, such as the Maldives".
The airline is also operating A380 flights to Cairo, Amman, Paris and Guangzhou.