One in eight people who contract coronavirus develop at least one symptom of long Covid, one of the most comprehensive studies on the condition to date suggested on Thursday.
With more than half a billion coronavirus cases recorded worldwide since the start of the pandemic, there has been rising concern about the lasting symptoms in people with long Covid.
But almost none of the existing research has compared long Covid sufferers with people who have never been infected, making it possible that some of the health problems were not caused by the virus.
A new study published in The Lancet journal asked more than 76,400 adults in the Netherlands to fill out an online questionnaire on 23 common long Covid symptoms.
Between March 2020 and August 2021, each participant filled out the questionnaire 24 times.
Of those with Covid, more than 21 per cent had at least one new or severely increased symptom three to five months after becoming infected.
But nearly 9 per cent of a control group who did not have Covid reported a similar increase.
This suggested that 12.7 per cent of those who had Covid, or about one in eight, suffered from long-term symptoms, the study said.
The research also recorded symptoms before and after Covid infection, allowing the researchers to further pinpoint exactly what was related to the virus.
World leaders with Covid-19 - in pictures
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US President Joe Biden tested positive for Covid-19 in July 2022. Reuters -
Former US president Donald Trump gives the thumbs-up after leaving the Walter Reed Medical Centre in Bethesda, Maryland, where he was treated for Covid-19 in October 2020. AFP -
Mr Trump removes his mask after returning to the White House from hospital in October 2020. AFP -
Algerian President Abdelmadjid Tebboune spent a month in Germany in January 2021, where he had surgery after developing complications linked to Covid-19. AFP -
Britain's Queen Elizabeth II had Covid-19 in February 2022, months before her death. AFP -
Britain's Prime Minister Boris Johnson caught Covid-19 in March 2020. AFP -
Canadian Prime Minister Justin Trudeau tested positive for Covid-19 a second time in July 2022, six months after he first contracted the virus. Reuters -
Mexican President Andres Manuel Lopez Obrador tested positive for Covid-19 in January 2022, after having first contracted the coronavirus in early 2021. AP -
Brazil's President Jair Bolsonaro tested positive for Covid-19 in July 2020. Reuters -
Departing Italian Prime Minister Mario Draghi contracted the virus that causes Covid-19 in April 2022. EPA
It found that common long Covid symptoms include chest pain, breathing difficulties, muscle pain, loss of taste and smell, and general fatigue.
One of the study's authors, Aranka Ballering of the Dutch University of Groningen, said long Covid was "an urgent problem with a mounting human toll".
"By looking at symptoms in an uninfected control group and in individuals both before and after SARS-CoV-2 infection, we were able to account for symptoms that may have been a result of non-infectious disease health aspects of the pandemic, such as stress caused by restrictions and uncertainty," Ms Ballering said.
Main syndromes related to long Covid - video
The authors of the study said its limits included that it did not cover later variants, such as Delta or Omicron, and did not collect information about some symptoms such as brain fog, which have since been considered a common sign of long Covid.
Another study author, Judith Rosmalen, said "future research should include mental health symptoms" such as depression and anxiety, as well as aspects such as brain fog, insomnia and a feeling of malaise after even minor exertion.
Christopher Brightling and Rachael Evans, experts from Britain's Leicester University who were not involved in the study, said it was "a major advance" on previous long Covid research because it had an uninfected control group.
"Encouragingly, emerging data from other studies" suggests there is a lower rate of long Covid in people who have been vaccinated or infected with the Omicron variant, they said in a linked Lancet comment.
