Denmark’s AstraZeneca vaccine ban could lead to ‘a lot of dead people’, says Prof John Bell

New Oxford study finds risk of rare blood clots higher after Covid infection than vaccination

epa09130198 A man receives his Covid-19 vaccine at the vaccination site at Arena Nord in Frederikshavn, Jutland, Denmark, 12 April 2021. Some 100,000 Danes are planned to be vaccinated against Covid-19 on 12 April 2021.  EPA/HENNING BAGGER  DENMARK OUT

One of the people behind the AstraZeneca-Oxford vaccine criticised Denmark for halting use of the drug completely and said it could lead to many more lives being lost.

Sir John Bell, regius professor of medicine at the University of Oxford, said a mix-and-match approach to coronavirus vaccines could offer better protection than using a single drug.
Denmark this week stopped using the AstraZeneca vaccine, the first country to impose a full ban because of links to rare blood clotting.

"They will have a lot of dead people, many more people than if they had used the AstraZeneca vaccine," Sir John said.

“They have to make their own decisions and live with those decisions and that may be more difficult as reality sinks in.

"The first, most important issue is these events are extremely rare, but if you get Covid you will have a very much higher risk of getting a clotting problem. The clotting problem is trivial compared with the risks of getting Covid," the academic said.
"Different countries have to do what they have to do. Denmark has 15 per cent of its population vaccinated but AstraZeneca is the only one they have widely available."

Meanwhile, researchers at the University of Oxford on Thursday reported that the risk of rare blood clotting after Covid-19 infection was about 100 times greater than normal, several times higher than post-vaccination or after influenza.

The study authors, led by Prof Paul Harrison and Dr Maxime Taquet from the University of Oxford's department of psychiatry and the NIHR Oxford Health Biomedical Research Centre, counted the cases of clotting, or cerebral venous thrombosis, in the two weeks after diagnosis of Covid-19, or after the first dose of a vaccine. They compared these with calculated incidences of CVT after influenza, and the background level in the general population.

The rare clotting was found to be more common after coronavirus infection, with 30 per cent of these cases occurring in under 30s. Compared with the Covid-19 vaccines in use, this risk is between eight and 10 times higher, and about 100 times higher when measure against the baseline.

Paul Harrison, professor of psychiatry and head of the Translational Neurobiology Group at the University of Oxford, said: "There are concerns about possible associations between vaccines, and CVT, causing governments and regulators to restrict the use of certain vaccines. Yet, one key question remained unknown: ‘What is the risk of CVT following a diagnosis of Covid-19?’.

"We’ve reached two important conclusions. First, Covid-19 markedly increases the risk of CVT, adding to the list of blood-clotting problems this infection causes. Second, the Covid-19 risk is higher than seen with the current vaccines, even for those under 30; something that should be taken into account when considering the balances between risks and benefits for vaccination."

Dr Maxime Taquet, also from the Translational Neurobiology Group, said it was important to note that the data should be interpreted cautiously.

"However, the signals that Covid-19 is linked to CVT, as well as portal vein thrombosis – a clotting disorder of the liver – is clear, and one we should take note of," she said.

Prof Bell, who is a member of the UK government's coronavirus task force, said he thought that a mix-and-match approach to vaccination was promising, but more research was required to test the theory that combining different drugs offered better protection.
"This is a really interesting strategy, probably more interesting in terms of dealing with variants," he said. "We believe if you mix the vaccines you will get a different type and a wider and stronger immune response.
"That would mean we are better able to deal with the South African variant and dozens of others popping up all over the world.
"As you start to mix and match, you will start to get an enhanced and more durable response. I think it is a really positive step forward."
He said the approach could lead to a vaccination programme that did not need a booster dose weeks or months down the line.