Edinson Cavani trained with Manchester United on Tuesday, eyeing a return against Crystal Palace.
Ole Gunnar Solskjaer's team are looking to revive their Premier League title bid and their efforts got a boost with the news of a possible return of their experienced forward who missed the last four games with a muscle complaint.
"We've had a training session this [Tuesday] morning," Solskjaer said.
"Of course it was a light one. Edinson trained, he joined in so that's good. Let's hope there's no reaction after the session. Hopefully he will travel with the squad."
Second-placed United are 15 points behind rivals and Premier League leaders Manchester City following a goalless draw away to Chelsea last weekend.
Juan Mata and Hannibal Mejbri remain absent for Wednesday's match, as does Paul Pogba due to a thigh complaint.
"Paul is still not ready for us," Solskjaer said. "He's feeling better.
"He's not been training with the team yet so he's definitely not travelling down to London."
While Pogba's return to action edges closer, it is unclear when long-serving defender Phil Jones will next line up for United.
The 29-year-old has not played for the club since January 2020 and underwent knee surgery over the summer.
Jones has now been added to the Premier League and Europa League squads, but Solskjaer is not sure when the England international will return.