Holders Manchester City were eliminated from the Carabao Cup by West Ham United after a penalty shootout at London Stadium on Wednesday.
The game went to penalties after ending goalless and the Hammers triumphed 5-3 in the spot kicks to end Pep Guardiola's team's run of four straight League Cup triumphs.
Substitute Phil Foden missed the first penalty for City and Said Benrahma converted the final kick to give the Hammers victory in what is becoming an excellent season for the East London club.
With Manchester United knocked out in the previous round, it means the cup will be won by a non-Manchester club for the first time since 2015.
Liverpool moved into the last eight of the competition with a 2-0 victory at Preston North End thanks to second half goals from Takumi Minamino and Divock Origi.
Leicester City edged out Brighton and Hove Albion on penalties after the game ended 2-2 after 90 minutes.
Harvey Barnes had put Leicester in front before two goals on the stroke of halftime, with Adam Wester levelling for Brighton only to see Ademola Lookman restore the Foxes' advantage.
Enock Mwepu forced the game to penalties after levelling in the 71st minute but the Zambian then missed the crucial spot kick in the shoot-out as Brendan Rodgers' side took their place in the quarter-finals.
Tottenham Hotspur also progressed after a 1-0 win at Burnley with Lucas Moura grabbing the 68th minute winner with a header from a Emerson Royal cross in a disappointing game.
Premier League Brentford took care of business against Championship Stoke City with Sergi Canos and Ivan Toney on target for the London club in a 2-1 win.
The draw for the quarter-finals, which also include Chelsea, Arsenal and third-tier Sunderland, will be held on Saturday.
Emergency
Director: Kangana Ranaut
Stars: Kangana Ranaut, Anupam Kher, Shreyas Talpade, Milind Soman, Mahima Chaudhry
Rating: 2/5
Haemoglobin disorders explained
Thalassaemia is part of a family of genetic conditions affecting the blood known as haemoglobin disorders.
Haemoglobin is a substance in the red blood cells that carries oxygen and a lack of it triggers anemia, leaving patients very weak, short of breath and pale.
The most severe type of the condition is typically inherited when both parents are carriers. Those patients often require regular blood transfusions - about 450 of the UAE's 2,000 thalassaemia patients - though frequent transfusions can lead to too much iron in the body and heart and liver problems.
The condition mainly affects people of Mediterranean, South Asian, South-East Asian and Middle Eastern origin. Saudi Arabia recorded 45,892 cases of carriers between 2004 and 2014.
A World Health Organisation study estimated that globally there are at least 950,000 'new carrier couples' every year and annually there are 1.33 million at-risk pregnancies.
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T20 World Cup Qualifier fixtures
Tuesday, October 29
Qualifier one, 2.10pm – Netherlands v UAE
Qualifier two, 7.30pm – Namibia v Oman
Wednesday, October 30
Qualifier three, 2.10pm – Scotland v loser of qualifier one
Qualifier four, 7.30pm – Hong Kong v loser of qualifier two
Thursday, October 31
Fifth-place playoff, 2.10pm – winner of qualifier three v winner of qualifier four
Friday, November 1
Semi-final one, 2.10pm – Ireland v winner of qualifier one
Semi-final two, 7.30pm – PNG v winner of qualifier two
Saturday, November 2
Third-place playoff, 2.10pm
Final, 7.30pm
RESULTS
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Under-21 European Championship Final
Germany 1 Spain 0
Weiser (40')
Name: Peter Dicce
Title: Assistant dean of students and director of athletics
Favourite sport: soccer
Favourite team: Bayern Munich
Favourite player: Franz Beckenbauer
Favourite activity in Abu Dhabi: scuba diving in the Northern Emirates