In Brazil about 100 buses are running on diesel fuel made from microbes.
Later this year the French drug company Sanofi will launch an anti-malaria drug also made from microbes.
What is common between these two events is the technology that has been used to make them happen - and the scientist behind these efforts.
Both the diesel fuel and the anti-malaria drug have been made from microbes using a technology called synthetic biology.
This involves inserting a dozen or more genes into microbes to make them produce drugs, chemicals or biofuels that they normally would not make.
Jay Keasling, a professor in the department of chemical and biomolecular engineering at the University of California in Berkeley, is using synthetic biology to engineer these microbes. Amyris Biotechnologies, a company he co-founded in California with a few other scientists, is taking this technology to market.
The biggest example of that will be visible later this year when Sanofi increases its production of an anti-malarial drug based on an ingredient called artemisinin.
Nearly 300 million people fall sick from malaria each year and more than half a million - mainly children under the age of five - die from the disease, mostly in the developing world because of lack of access to affordable, effective drugs.
The chloroquine-based drugs that have been traditionally used to fight malaria are no longer particularly effective.
However, this debilitating disease can be treated with new medicines that have artemisinin as a core ingredient. Yet as artemisinin is found in one particular plant, sweet wormwood, cultivating and extracting it for large-scale use is a time-consuming and expensive process, especially in the poorer countries that need this medicine the most.
Prof Keasling used synthetic biology to engineer a microbe to produce artemisinin in the laboratory - enabling it to be produced more quickly and at a much lower cost. Amyris has licensed the technology to Sanofi, which is planning to make the artemisinin-based anti-malarial drug available in the market later this year, Prof Keasling says.
"Sanofi has already produced enough artemisinin for about 70 million people and will be able to produce for up to 120 million people every year," he adds.
Prof Keasling believes synthetic biology and the process of artificially developing microbes have a wide range of applications.
"Once you produce these platform microbes, those molecules can be substitutes for all the molecules we get from hydrocarbons," he says.
Apart from the anti-malarial drug, Amyris is also currently using this process to make transport fuel and chemicals for cosmetics and fragrances.
"In between fuels and drugs are all the chemicals we use on a regular basis and we can expect to use microbes for all of those," Prof Keasling says.
For his efforts in the field of biomolecular engineering, he has been selected by the Biotechnology Industry Organisation as this year's recipient of its George Washington Carver Award for innovation in industrial biotechnology.
The industry body represents more than 1,100 biotechnology companies and academic institutions in the United States and 30 other countries.
Prof Keasling, a native of Nebraska who was born and raised on a corn farm, says he realised the significance of platform microbes only when he and his team were finishing their work on artemisinin around 2007.
The anti-malarial drug, he noticed, was a hydrocarbon and had some similarities to diesel fuel and jet fuel.
"We modified the chemistry in the microbes and realised it wouldn't take too much work to produce the kind of fuel we want," he says.
"The importance of that is that you don't need to change the transportation infrastructure."
That means the fuel produced can be directly used in cars, lorries and aircraft, without modifying the engines of the vehicles, unlike when using ethanol.
One way to boost production of this easy-to-use fuel is to convert the biomass of non-food crops and agricultural waste into fuels for cars and jet planes.
Prof Keasling says the United States has hundreds of thousands acres of marginal land that is not adequate for producing food but can be used to grow bioenergy crops such switchgrass and acanthus grass, which can then be converted into renewable fuels.
About an acre of these plants could produce hundreds of gallons of advance transportation fuels.
But even though these plants have a high sugar content it is still very difficult to extract it.
In his laboratory Prof Keasling is engineering these plants to more readily give up their sugars.
He is also developing microbes that can extract the sugars from without significant pre-treatment and turn them into transport fuels similar to petrol, diesel and jet fuels.
Amyris is testing this technology in Brazil, where it is converting sugarcane into diesel. The buses running in São Paolo on this fuel are part of the experiment and Prof Keasling claims Amyris' diesel molecule gives better mileage and reduces the amount of carbon in the atmosphere by 80 per cent over conventional fuel.
But at nearly $8 a gallon, about twice the price of diesel in the US, it is too expensive to produce commercially as yet.
"The challenge with fuel is it has to be extremely inexpensive," says Prof Keasling.
What would help in mass adoption - and a significant drop in price - of the fuel, he says, is if governments charged companies for carbon that is emitted into the atmosphere.
"We put no cost on that so it makes it very difficult to compete with conventional fuel," he says.
"We need a carbon tax or carbon trading that would make renewable fuel more competitive."
[ business@thenational.ae ]
The specs
Engine: 3.9-litre twin-turbo V8
Power: 620hp from 5,750-7,500rpm
Torque: 760Nm from 3,000-5,750rpm
Transmission: Eight-speed dual-clutch auto
On sale: Now
Price: From Dh1.05 million ($286,000)
Company Profile
Company name: Namara
Started: June 2022
Founder: Mohammed Alnamara
Based: Dubai
Sector: Microfinance
Current number of staff: 16
Investment stage: Series A
Investors: Family offices
Company Profile
Company: Astra Tech
Started: March 2022
Based: Dubai
Founder: Abdallah Abu Sheikh
Industry: technology investment and development
Funding size: $500m
Score
Third Test, Day 1
New Zealand 229-7 (90 ov)
Pakistan
New Zealand won the toss and elected to bat
Liverpool’s fixtures until end of 2019
Saturday, November 30, Brighton (h)
Wednesday, December 4, Everton (h)
Saturday, December 7, Bournemouth (a)
Tuesday, December 10, Salzburg (a) CL
Saturday, December 14, Watford (h)
Tuesday, December 17, Aston Villa (a) League Cup
Wednesday, December 18, Club World Cup in Qatar
Saturday, December 21, Club World Cup in Qatar
Thursday, December 26, Leicester (a)
Sunday, December 29, Wolves (h)
SCORES IN BRIEF
Lahore Qalandars 186 for 4 in 19.4 overs
(Sohail 100,Phil Salt 37 not out, Bilal Irshad 30, Josh Poysden 2-26)
bt Yorkshire Vikings 184 for 5 in 20 overs
(Jonathan Tattersall 36, Harry Brook 37, Gary Ballance 33, Adam Lyth 32, Shaheen Afridi 2-36).
The Specs
Engine: 1.6-litre 4-cylinder petrol
Power: 118hp
Torque: 149Nm
Transmission: Six-speed automatic
Price: From Dh61,500
On sale: Now
Specs: 2024 McLaren Artura Spider
Engine: 3.0-litre twin-turbo V6 and electric motor
Max power: 700hp at 7,500rpm
Max torque: 720Nm at 2,250rpm
Transmission: Eight-speed dual-clutch auto
0-100km/h: 3.0sec
Top speed: 330kph
Price: From Dh1.14 million ($311,000)
On sale: Now
Herc's Adventures
Developer: Big Ape Productions
Publisher: LucasArts
Console: PlayStation 1 & 5, Sega Saturn
Rating: 4/5
Russia's Muslim Heartlands
Dominic Rubin, Oxford
The biog
Born: Kuwait in 1986
Family: She is the youngest of seven siblings
Time in the UAE: 10 years
Hobbies: audiobooks and fitness: she works out every day, enjoying kickboxing and basketball
The BIO:
He became the first Emirati to climb Mount Everest in 2011, from the south section in Nepal
He ascended Mount Everest the next year from the more treacherous north Tibetan side
By 2015, he had completed the Explorers Grand Slam
Last year, he conquered K2, the world’s second-highest mountain located on the Pakistan-Chinese border
He carries dried camel meat, dried dates and a wheat mixture for the final summit push
His new goal is to climb 14 peaks that are more than 8,000 metres above sea level
Book Details
Three Centuries of Travel Writing by Muslim Women
Editors: Siobhan Lambert-Hurley, Daniel Majchrowicz, Sunil Sharma
Publisher: Indiana University Press; 532 pages
THE BIO
Favourite place to go to in the UAE: The desert sand dunes, just after some rain
Who inspires you: Anybody with new and smart ideas, challenging questions, an open mind and a positive attitude
Where would you like to retire: Most probably in my home country, Hungary, but with frequent returns to the UAE
Favorite book: A book by Transilvanian author, Albert Wass, entitled ‘Sword and Reap’ (Kard es Kasza) - not really known internationally
Favourite subjects in school: Mathematics and science
Kill Bill Volume 1
Director: Quentin Tarantino
Stars: Uma Thurman, David Carradine and Michael Madsen
Rating: 4.5/5
The bio
Favourite book: Peter Rabbit. I used to read it to my three children and still read it myself. If I am feeling down it brings back good memories.
Best thing about your job: Getting to help people. My mum always told me never to pass up an opportunity to do a good deed.
Best part of life in the UAE: The weather. The constant sunshine is amazing and there is always something to do, you have so many options when it comes to how to spend your day.
Favourite holiday destination: Malaysia. I went there for my honeymoon and ended up volunteering to teach local children for a few hours each day. It is such a special place and I plan to retire there one day.
TWISTERS
Director:+Lee+Isaac+Chung
Starring:+Glen+Powell,+Daisy+Edgar-Jones,+Anthony+Ramos
Rating:+2.5/5
COMPANY PROFILE
Name: Elmawkaa
Based: Hub71, Abu Dhabi
Founders: Ebrahem Anwar, Mahmoud Habib and Mohamed Thabet
Sector: PropTech
Total funding: $400,000
Investors: 500 Startups, Flat6Labs and angel investors
Number of employees: 12
KEY DATES IN AMAZON'S HISTORY
July 5, 1994: Jeff Bezos founds Cadabra Inc, which would later be renamed to Amazon.com, because his lawyer misheard the name as 'cadaver'. In its earliest days, the bookstore operated out of a rented garage in Bellevue, Washington
July 16, 1995: Amazon formally opens as an online bookseller. Fluid Concepts and Creative Analogies: Computer Models of the Fundamental Mechanisms of Thought becomes the first item sold on Amazon
1997: Amazon goes public at $18 a share, which has grown about 1,000 per cent at present. Its highest closing price was $197.85 on June 27, 2024
1998: Amazon acquires IMDb, its first major acquisition. It also starts selling CDs and DVDs
2000: Amazon Marketplace opens, allowing people to sell items on the website
2002: Amazon forms what would become Amazon Web Services, opening the Amazon.com platform to all developers. The cloud unit would follow in 2006
2003: Amazon turns in an annual profit of $75 million, the first time it ended a year in the black
2005: Amazon Prime is introduced, its first-ever subscription service that offered US customers free two-day shipping for $79 a year
2006: Amazon Unbox is unveiled, the company's video service that would later morph into Amazon Instant Video and, ultimately, Amazon Video
2007: Amazon's first hardware product, the Kindle e-reader, is introduced; the Fire TV and Fire Phone would come in 2014. Grocery service Amazon Fresh is also started
2009: Amazon introduces Amazon Basics, its in-house label for a variety of products
2010: The foundations for Amazon Studios were laid. Its first original streaming content debuted in 2013
2011: The Amazon Appstore for Google's Android is launched. It is still unavailable on Apple's iOS
2014: The Amazon Echo is launched, a speaker that acts as a personal digital assistant powered by Alexa
2017: Amazon acquires Whole Foods for $13.7 billion, its biggest acquisition
2018: Amazon's market cap briefly crosses the $1 trillion mark, making it, at the time, only the third company to achieve that milestone
Score
Third Test, Day 2
New Zealand 274
Pakistan 139-3 (61 ov)
Pakistan trail by 135 runs with 7 wickets remaining in the innings
COMPANY PROFILE
Company name: Klipit
Started: 2022
Founders: Venkat Reddy, Mohammed Al Bulooki, Bilal Merchant, Asif Ahmed, Ovais Merchant
Based: Dubai, UAE
Industry: Digital receipts, finance, blockchain
Funding: $4 million
Investors: Privately/self-funded
if you go
The flights
Emirates offer flights to Buenos Aires from Dubai, via Rio De Janeiro from around Dh6,300. emirates.com
Seeing the games
Tangol sell experiences across South America and generally have good access to tickets for most of the big teams in Buenos Aires: Boca Juniors, River Plate, and Independiente. Prices from Dh550 and include pick up and drop off from your hotel in the city. tangol.com
Staying there
Tangol will pick up tourists from any hotel in Buenos Aires, but after the intensity of the game, the Faena makes for tranquil, upmarket accommodation. Doubles from Dh1,110. faena.com
Last-16
France 4
Griezmann (13' pen), Pavard (57'), Mbappe (64', 68')
Argentina 3
Di Maria (41'), Mercado (48'), Aguero (90+3')
The specs: 2017 Dodge Ram 1500 Laramie Longhorn
Price, base / as tested: Dhxxx
Engine: 5.7L V8
Transmission: Eight-speed automatic
Power: 395hp @ 5,600rpm
Torque: 556Nm @ 3,950rpm
Fuel economy, combined: 12.7L / 100km