Sheikh Mohamed made the comments as he visited the show, which has been taking place in Dubai since Monday.
He also emphasised the importance of the aviation industry, which has the knock-on effect of stimulating growth in several related sectors.
“The continuous success the air show achieves is an embodiment of the UAE's position as an influential partner in the aviation industry,” said Sheikh Mohamed, in comments carried by state news agency Wam.
“The exhibition is a global platform that brings together decision makers, sector leaders, experts and stakeholders who discuss the latest innovative solutions and future trends in developing the world of aviation and creating a better future for this sector.
“The aviation sector represents one of the most important vital fields that stimulate and support the growth of many sectors related to this industry.”
Sheikh Mohamed was accompanied by Sheikh Mansour bin Zayed, Vice President, Deputy Prime Minister and Chairman of the Presidential Court.
Also visiting the airshow on Wednesday was Sheikh Hamdan bin Mohammed, Crown Prince of Dubai.
Sheikh Hamdan hailed the event's “growing status as a platform for the global aviation sector to explore new opportunities for growth and innovation”.
“The growing international significance of the trade show is reflected in the multibillion-dollar deals signed during this year’s event,” he said.
“The economic impact of the event highlights the role it plays in fostering global co-operation and sustainable technologies in the aviation industry.”
Sheikh Khaled bin Mohamed, Crown Prince of Abu Dhabi, also toured the event, which he said strengthened the UAE’s position as a major global aerospace player and a hub for innovation.
“The Dubai Airshow reflects the UAE’s strategic focus on integrating aerospace innovation with advanced technology and sustainability,” he said.
The Dubai Airshow is taking place at Al Maktoum International Airport until November 17.