"Earlier today, deputies were called to the Ritz-Carlton Orlando, Grande Lakes for a call about an unresponsive man in a hotel room. The man was identified as Robert Saget & pronounced deceased on scene. Detectives found no signs of foul play or drug use in this case," the Orange County Sheriff's Office tweeted from its verified account.
Saget, who was 65, starred as widowed father of three girls Danny Tanner in Full House. His efforts to raise them – assisted by his brother-in-law Jesse and friend Joey – formed the heart of the popular sitcom.
It ran for eight seasons, from 1987-1995, on ABC. Netflix broadcast a sequel focusing on one of Danny's daughters, DJ Tanner, which ran from 2016-2020.
Saget, who was also a popular host of America's Funniest Home Videos, had been touring the country recently.
Just hours before his death was announced, he tweeted to say what fun he had doing a show in Jacksonville.
He is survived by his wife, Kelly Rizzo, and three children.
"Bob Saget was a beloved and boundary-pushing comedian. He'll be missed," tweeted the official account for the Comedy Central television channel.