Coronavirus: In finding a vaccine, why fortune favours the brave


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When Boris Johnson hosts the Global Vaccine Summit on Thursday, the UK Prime Minister can fairly point to the lessons from exactly 300 years ago when a smallpox outbreak threatened London.

In the years leading up to the epidemic, Lady Mary Wortley Montagu had been the wife of the British ambassador to Constantinople. Her life had been literally and emotionally marked by smallpox, a now extinct disease that was no respecter of high rank or wealth.

She herself had contracted the fever and her brother had died from it. Outbreaks had the capacity to shut down early 18th century cities as Covid-19 has hit the world today.

Lady Mary Wortley Montagu's life had been marked by smallpox, a now extinct disease that was no respecter of high rank or wealth. Getty Images
Lady Mary Wortley Montagu's life had been marked by smallpox, a now extinct disease that was no respecter of high rank or wealth. Getty Images

During her time in what we call Turkey today, Lady Mary noticed locals had none of the pocked skin that was the legacy of the illness. She made enquiries and was pointed to a local treatment. When the summer heat faded, the women of Istanbul held “parties” when the virus was administered from a “nutshell by a needle”.

In a letter dating from 1717, she noted the smallpox, “so fatal and so general amongst us, is here entirely harmless”.

Just before she was recalled from the Ottoman Court, Lady Mary and the embassy doctor took her three-year-old son to undergo an inoculation. The ambassador’s wife was sure she had done the right thing. “I am patriot enough to take pains to bring this useful invention to fashion in England,” she said.

On her return, she faced a great fight to get the practice accepted. Lady Mary worked with Hans Soane and Richard Mead to carry out trials in Newgate Prison in 1721.

In the same year, Lady Mary had her infant daughter inoculated as smallpox outbreak raged. Claude Amyand, a French refugee who was surgeon to the court of King George, administered smallpox to the monarch's grandchildren. But despite the royal seal of approval, the concept of vaccination remained controversial and disparaged.

  • Kuwaiti children cycle in a street in the Salwa district of Kuwait City. AFP
    Kuwaiti children cycle in a street in the Salwa district of Kuwait City. AFP
  • Palestinian students have their body temperature checked as they arrive to take high school exams in Gaza City. Reuters
    Palestinian students have their body temperature checked as they arrive to take high school exams in Gaza City. Reuters
  • An Iraqi woman, who had been stranded in Iran due to the novel coronavirus pandemic, gets her temperature checked by a health worker upon her arrival to Iraq via the Al-Shalamija border crossing, west of the southern city of Basra. AFP
    An Iraqi woman, who had been stranded in Iran due to the novel coronavirus pandemic, gets her temperature checked by a health worker upon her arrival to Iraq via the Al-Shalamija border crossing, west of the southern city of Basra. AFP
  • Palestinian students take high school exams in a classroom, amid concerns about the spread of coronavirus, in Gaza City. Reuters
    Palestinian students take high school exams in a classroom, amid concerns about the spread of coronavirus, in Gaza City. Reuters
  • A woman wearing a protective face mask walks past a Starbucks coffee shop in Hamra street, Beirut, Lebanon. Reuters
    A woman wearing a protective face mask walks past a Starbucks coffee shop in Hamra street, Beirut, Lebanon. Reuters
  • Imad Fawzi Shueibi, 59, professor of epistemology at Damascus University, speaks during an interview with AFP via video call from his home in the Syrian capital Damascus. The coronavirus pandemic could create a new world order in which everyone is a loser and new alliances are born to overcome disaster, according to the Syrian thinker. AFP
    Imad Fawzi Shueibi, 59, professor of epistemology at Damascus University, speaks during an interview with AFP via video call from his home in the Syrian capital Damascus. The coronavirus pandemic could create a new world order in which everyone is a loser and new alliances are born to overcome disaster, according to the Syrian thinker. AFP
  • A man walks past the Damascus Gate as it sits empty near the Dome of the Rock and al-Aqsa mosque compound, which remains shut to prevent the spread of coronavirus in Jerusalem's Old City. AP Photo
    A man walks past the Damascus Gate as it sits empty near the Dome of the Rock and al-Aqsa mosque compound, which remains shut to prevent the spread of coronavirus in Jerusalem's Old City. AP Photo
  • An anti-government protester shouts slogans in font of riot policemen during a protest in Beirut, Lebanon. AP Photo
    An anti-government protester shouts slogans in font of riot policemen during a protest in Beirut, Lebanon. AP Photo
  • An elderly man and woman walk next to closed shops in central Baghdad, Iraq. EPA
    An elderly man and woman walk next to closed shops in central Baghdad, Iraq. EPA
  • Moroccans in a street in Casablanca, as authorities start to ease restrictions. AFP
    Moroccans in a street in Casablanca, as authorities start to ease restrictions. AFP
  • A teacher wearing face mask gives a lesson at a classroom at 'Riadh' high school, in La Marsa in the suburbs of Tunis, Tunisia, after authorities approved the easening of measures put in place due to the coronavirus pandemic. EPA
    A teacher wearing face mask gives a lesson at a classroom at 'Riadh' high school, in La Marsa in the suburbs of Tunis, Tunisia, after authorities approved the easening of measures put in place due to the coronavirus pandemic. EPA
  • Passengers waiting to board a repatriation flight from the Algerian capital Algiers to France. AFP
    Passengers waiting to board a repatriation flight from the Algerian capital Algiers to France. AFP

There was another outbreak in 1740 and another French refugee doctor, Matthew Maty, fought a new more successful campaign to put a stop to unnecessary deaths. The method spread worldwide but it was not until 1980 that the United Nations said it was eradicated and in 1997 when the last case was declared.

Fortune therefore ultimately favoured the brave pioneers of vaccination defying even the recent rise of a conspiracy-based denier movement.

The British-led summit on Thursday marks the 20th anniversary of the founding of Gavi, the vaccine alliance, and aims to raise $7.4 billion for its global goals up to 2025. The organisers want the world to unite around three main truths that they say have been highlighted by Covid-19 crisis: vaccines are essential for protection of health and wealth; everyone must be protected or no one is; the alliance helps the world go further and faster.

The timing of the meeting could not be more on point. Analysts have detected at least 85 countries that have placed bans or export restrictions on medicines and equipment for treatment of Covid-19. In what has been described as the global gold rush to defeat the 29 microscopic proteins that make up the coronavirus, there are more than 100 candidate vaccines under development.

The investment is massive and each backer will want to see appropriate reward for success. Novaris, which was the leader of the pack in the H1N1 pandemic, has said there is no short cut to the 18-month-to-two-year-timeframe for developing a successive option.

  • People gather for a peaceful rally in support of George Floyd in front of the police station in Des Moines, Iowa. Floyd died earlier this week in police custody in Minneapolis. AP
    People gather for a peaceful rally in support of George Floyd in front of the police station in Des Moines, Iowa. Floyd died earlier this week in police custody in Minneapolis. AP
  • An employee cleans a table before offering it to customers at the Gato terrace in Madrid, Spain. All regions of Spain have now entered either Phase One or Phase Two of the transition from its coronavirus lockdown. Getty Images
    An employee cleans a table before offering it to customers at the Gato terrace in Madrid, Spain. All regions of Spain have now entered either Phase One or Phase Two of the transition from its coronavirus lockdown. Getty Images
  • Activists walk along the street during a Covid-19 awareness campaign in Kinshasa. Many people in Kinshasa deny the reality of the coronavirus which has officially affected 2833 people and killed 61, with a growing number of daily new cases. AFP
    Activists walk along the street during a Covid-19 awareness campaign in Kinshasa. Many people in Kinshasa deny the reality of the coronavirus which has officially affected 2833 people and killed 61, with a growing number of daily new cases. AFP
  • People enjoy a gondola ride under the Bridge of Sighs (Ponte dei Sospiri) in Venice, as Italy eases its lockdown. AFP
    People enjoy a gondola ride under the Bridge of Sighs (Ponte dei Sospiri) in Venice, as Italy eases its lockdown. AFP
  • People wearing masks walk with the Singapore Flyer and The Central Business district area in the background in Singapore. EPA
    People wearing masks walk with the Singapore Flyer and The Central Business district area in the background in Singapore. EPA
  • A member of parliament undergoes a swab test for coronavirus ahead of parliament session in Yangon, Myanmar. EPA
    A member of parliament undergoes a swab test for coronavirus ahead of parliament session in Yangon, Myanmar. EPA
  • Officials of a Buddhist temple check congregants' temperatures before allowing entry to a temple on South Korea's southern resort island of Jeju, South Korea. EPA
    Officials of a Buddhist temple check congregants' temperatures before allowing entry to a temple on South Korea's southern resort island of Jeju, South Korea. EPA
  • People attend a ceremony of Buddha's birthday at Jogyesa Temple in Seoul, South Korea. Getty Images
    People attend a ceremony of Buddha's birthday at Jogyesa Temple in Seoul, South Korea. Getty Images
  • The Fremont Street Experience Viva Vision canopy attraction displays a countdown leading up to the June 4 reopening of hotel-casinos, which have been closed since March 17, in Las Vegas, Nevada. Getty Images
    The Fremont Street Experience Viva Vision canopy attraction displays a countdown leading up to the June 4 reopening of hotel-casinos, which have been closed since March 17, in Las Vegas, Nevada. Getty Images
  • In this photo released by Chinese nurse Zhang Dan, she looks after a patient being treated for Covid-19 at the Tongji hospital in Wuhan in central China's Hubei province. AP
    In this photo released by Chinese nurse Zhang Dan, she looks after a patient being treated for Covid-19 at the Tongji hospital in Wuhan in central China's Hubei province. AP
  • Workers sit on stools along a street in Hanoi, Vietnam. Bloomberg
    Workers sit on stools along a street in Hanoi, Vietnam. Bloomberg
  • Sanitation at the Las Pulgas market in Maracaibo, Venezuela. EPA
    Sanitation at the Las Pulgas market in Maracaibo, Venezuela. EPA
  • Christopher Bagay, a kitchen crew of the Aida Sol cruise ship in Europe, walks beside children's toys upon arriving at his home in Laguna province, south of Manila, Philippines.AP Photo
    Christopher Bagay, a kitchen crew of the Aida Sol cruise ship in Europe, walks beside children's toys upon arriving at his home in Laguna province, south of Manila, Philippines.AP Photo
  • An aerial view of residents watching the movie 'Trolls' at a drive-in movie arranged by Nassau County at the parking lot of NYCB's LIVE at the Nassau Coliseum in Uniondale, New York. Getty Images
    An aerial view of residents watching the movie 'Trolls' at a drive-in movie arranged by Nassau County at the parking lot of NYCB's LIVE at the Nassau Coliseum in Uniondale, New York. Getty Images
  • An employee wearing a protective mask cleans a entrance of a restaurant in Yurakucho district of Tokyo, Japan. Bloomberg
    An employee wearing a protective mask cleans a entrance of a restaurant in Yurakucho district of Tokyo, Japan. Bloomberg
  • A Venezuelan migrant wearing a face mask is seen standing in line to receive food aid in Bogota, Colombia. Reuters
    A Venezuelan migrant wearing a face mask is seen standing in line to receive food aid in Bogota, Colombia. Reuters

Sinovac, a Beijing company, has said it is 99 per cent sure that its treatment will prove effective. It is wrapping up second stage trials but is unsure where it can launch the stage three tests as China’s infection rate has fallen.

Amid the calls for universal access to a breakthrough vaccine, the US has launched Operation Warp Speed to pick winners in the research stakes. The UK government provided money to Oxford University researchers and brokered a deal with AstraZeneca to get first access to 30 million of the planned 100 million batches of the vaccine it plans to roll out.

Institutes have suddenly become the target of cyber attacks traced to regimes such as Iran and North Korea that are seeking access to secret data.

Facing criticism in the US, the Trump administration said therapeutic treatments for Covid-19 ranked just as important as the hunt for vaccine. Drugs such as remdesivir, which has been repurposed from an Ebola treatment, have improved survival chances of those contracting the virus.

Meanwhile, the urgent need to restart social and economic activity, whether or not the vaccine summit heralds success, grows every day. In such a scenario, wearing a mask day in, day out is crucial now. Social distancing must be observed in offices, airports and shops. Disinfection campaigns and good hygiene are crucial.

These are all brave and necessary choices that are not limited to the vaccine hunters.

Damien McElroy is the London bureau chief of The National

Ten tax points to be aware of in 2026

1. Domestic VAT refund amendments: request your refund within five years

If a business does not apply for the refund on time, they lose their credit.

2. E-invoicing in the UAE

Businesses should continue preparing for the implementation of e-invoicing in the UAE, with 2026 a preparation and transition period ahead of phased mandatory adoption. 

3. More tax audits

Tax authorities are increasingly using data already available across multiple filings to identify audit risks. 

4. More beneficial VAT and excise tax penalty regime

Tax disputes are expected to become more frequent and more structured, with clearer administrative objection and appeal processes. The UAE has adopted a new penalty regime for VAT and excise disputes, which now mirrors the penalty regime for corporate tax.

5. Greater emphasis on statutory audit

There is a greater need for the accuracy of financial statements. The International Financial Reporting Standards standards need to be strictly adhered to and, as a result, the quality of the audits will need to increase.

6. Further transfer pricing enforcement

Transfer pricing enforcement, which refers to the practice of establishing prices for internal transactions between related entities, is expected to broaden in scope. The UAE will shortly open the possibility to negotiate advance pricing agreements, or essentially rulings for transfer pricing purposes. 

7. Limited time periods for audits

Recent amendments also introduce a default five-year limitation period for tax audits and assessments, subject to specific statutory exceptions. While the standard audit and assessment period is five years, this may be extended to up to 15 years in cases involving fraud or tax evasion. 

8. Pillar 2 implementation 

Many multinational groups will begin to feel the practical effect of the Domestic Minimum Top-Up Tax (DMTT), the UAE's implementation of the OECD’s global minimum tax under Pillar 2. While the rules apply for financial years starting on or after January 1, 2025, it is 2026 that marks the transition to an operational phase.

9. Reduced compliance obligations for imported goods and services

Businesses that apply the reverse-charge mechanism for VAT purposes in the UAE may benefit from reduced compliance obligations. 

10. Substance and CbC reporting focus

Tax authorities are expected to continue strengthening the enforcement of economic substance and Country-by-Country (CbC) reporting frameworks. In the UAE, these regimes are increasingly being used as risk-assessment tools, providing tax authorities with a comprehensive view of multinational groups’ global footprints and enabling them to assess whether profits are aligned with real economic activity. 

Contributed by Thomas Vanhee and Hend Rashwan, Aurifer

'Operation Mincemeat' 

Director: John Madden 

 

Cast: Colin Firth, Matthew Macfayden, Kelly Macdonald and Penelope Wilton

 

Rating: 4/5

 
Key products and UAE prices

iPhone XS
With a 5.8-inch screen, it will be an advance version of the iPhone X. It will be dual sim and comes with better battery life, a faster processor and better camera. A new gold colour will be available.
Price: Dh4,229

iPhone XS Max
It is expected to be a grander version of the iPhone X with a 6.5-inch screen; an inch bigger than the screen of the iPhone 8 Plus.
Price: Dh4,649

iPhone XR
A low-cost version of the iPhone X with a 6.1-inch screen, it is expected to attract mass attention. According to industry experts, it is likely to have aluminium edges instead of stainless steel.
Price: Dh3,179

Apple Watch Series 4
More comprehensive health device with edge-to-edge displays that are more than 30 per cent bigger than displays on current models.

The National Archives, Abu Dhabi

Founded over 50 years ago, the National Archives collects valuable historical material relating to the UAE, and is the oldest and richest archive relating to the Arabian Gulf.

Much of the material can be viewed on line at the Arabian Gulf Digital Archive - https://www.agda.ae/en

Quick pearls of wisdom

Focus on gratitude: And do so deeply, he says. “Think of one to three things a day that you’re grateful for. It needs to be specific, too, don’t just say ‘air.’ Really think about it. If you’re grateful for, say, what your parents have done for you, that will motivate you to do more for the world.”

Know how to fight: Shetty married his wife, Radhi, three years ago (he met her in a meditation class before he went off and became a monk). He says they’ve had to learn to respect each other’s “fighting styles” – he’s a talk it-out-immediately person, while she needs space to think. “When you’re having an argument, remember, it’s not you against each other. It’s both of you against the problem. When you win, they lose. If you’re on a team you have to win together.” 

THE SPECS

Engine: 3.5-litre V6
Transmission: six-speed manual
Power: 325bhp
Torque: 370Nm
Speed: 0-100km/h 3.9 seconds
Price: Dh230,000
On sale: now

How to watch Ireland v Pakistan in UAE

When: The one-off Test starts on Friday, May 11
What time: Each day’s play is scheduled to start at 2pm UAE time.
TV: The match will be broadcast on OSN Sports Cricket HD. Subscribers to the channel can also stream the action live on OSN Play.