The Hello singer was nominated in the outstanding variety special (pre-recorded) category for her One Night Only show, which took place earlier this year.
EGOT status refers to individuals who win all four major entertainment awards — an Emmy, Grammy, Oscar and a Tony.
Adele won the Oscar for best original song in 2013 for her James Bond theme tune Skyfall, and has won 15 Grammy awards across several categories.
She was nominated for an Emmy in 2016 in the same category as this year for her Adele Live in New York City special on NBC, but did not win.
She has never been nominated for a Tony.
The prestigious EGOT status has only been awarded to 17 individuals previously, and the list includes such notable figures as Andrew Lloyd Webber, Rita Moreno, John Legend and Whoopi Goldberg.
Jennifer Hudson became the most recent celebrity to make the list, following her Tony award last month.
All 17 members of the EGOT winners club — in pictures
'Squid Game' makes history at Primetime Emmy Awards 2022
Succession received a leading 25 Emmy nominations on Tuesday, but the satirical drama about the rich and ruthless has a major rival in Squid Game, the first non-English language series to vie for television’s top honour.
Netflix show Squid Game, a South Korean drama in which poor people compete for cash in a series of brutal games, earned a Best Drama nomination and 13 other nods in the coming Emmy Awards, which will take place in September.
HBO show Succession won the gong for Best Drama and eight other awards at the Emmy Awards in 2020.
A separate International Emmys ceremony has been held since 1973, but no foreign language show has ever broken into the Primetime Emmys drama ranks.
Apple TV+ show Ted Lasso was the top comedy nominee with 20 bids and has the chance to earn its second consecutive Best Comedy trophy, as academy voters proved undeterred by its sophomore season turn to the emotional dark side.
Other top nominees included the tropical resort-set anthology dramedy The White Lotus, which also received 20 nominations; the comedies Hacks and Only Murders in the Building with 17 bids each, and teenage drama Euphoria.
— Additional reporting from PA Media