Premier League predictions: Liverpool smash Manchester United, Chelsea power past Arsenal

We pick out the winners and losers from the midweek English top-flight fixtures

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  Liverpool's Sadio Mane (R) celebrates after scoring during the English FA Cup semi final match between Manchester City and Liverpool at Wembley Stadium, London, Britain, 16 April 2022. EPA / VINCENT MIGNOTT

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  WEDNESDAY - Chelsea v Arsenal (10.45pm): Booking an FA Cup final spot gave Chelsea a lift on Sunday following their Champions League exit to Real Madrid. Top-four chasing Arsenal fell to a third defeat on the spin, losing 1-0 at Southampton, form that manager Mikel Arteta admitted is "a real worry". Prediction: Chelsea 2 Arsenal 0. PA

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  Everton v Leicester (10.45pm): Everton will be hoping for another home boost in their relegation battle following a win over Manchester United at a raucous Goodison Park last time out. Leicester's league campaign is in danger of petering out as the chance of European silverware takes priority. Prediction: Everton 2 Leicester 2. AP

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  Newcastle v Crystal Palace (10.45pm): The Magpies' top-flight status is all but secured after their injury-time win over Leicester on Sunday when new crowd favourite Bruno Guimaraes scored both goals at St James' Park. Palace saw their FA Cup dreams ended by Chelsea but are safely mid-table in the league and are a tough team to break down under Patrick Vieira. Prediction: Newcastle 2 Palace 1. Reuters

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  Manchester City v Brighton (11pm): City need an instant reaction after their FA Cup defeat to Liverpool with Jurgen Klopp's side also breathing down their necks at the top of the league table. Brighton stunned Spurs on Saturday but taking down City at the Etihad will be a step too far. Prediction: City 4 Brighton 1. EPA

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  THURSDAY - Burnley v Southampton (10.45pm): Despite the shock sacking of Sean Dyche, Burnley showed plenty of fight in their draw at West Ham on Sunday. They need wins, though, and Southampton showed with their 1-0 defeat of Arsenal that they are capable of upsetting better sides than the Clarets. Prediction: Burnley 1 Southampton 2. Reuters

Games are coming thick and fast now as the English club season heads towards an exciting climax.

Ahead a full set of fixtures at the weekend, there is a midweek schedule to work our way through first.

A huge game to start off with on Tuesday when quadruple-chasing Liverpool take on old rivals Manchester United at Anfield. Tragically, events off the pitch have cast a shadow over the game with the news that United striker Cristiano Ronaldo and his partner Georgina Rodríguez's newborn son had passed away.

Wednesday sees the London derby between Chelsea and Arsenal, Everton versus Leicester City at Goodison Park, Newcastle United entertaining Crystal Palace on Tyneside and Manchester City taking on Brighton at the Etihad Stadium.

Burnley face Southampton at Turf Moor on Thursday.

You can see out predictions for the midweek games in the gallery above. To move on to the next photo, click on the arrows or if using a mobile device, simply swipe.